Mentored Vision Clinician-Scientist Program at OHSU

OHSU 指导视力临床医生-科学家项目

• 批准号: 9913547
• 负责人: JOHN C MORRISON
• 金额: $ 26.57万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913547
• 关键词: Advisory Committees; Area; Basic Science; Blindness; Chicago; Clinical; Clinical Research; Clinical Trials; Education; Environment; Faculty; Frequencies; Fright; Goals; Health Sciences; Human; Image; Individual; Institutes; Investigation; Knowledge; Medical Research; Mentored Clinical Scientist Development Program; Mentors; Molecular Genetics; Ophthalmologist; Ophthalmology; Oregon; Patient Care; Research; Research Institute; Research Project Grants; Research Support; Research Training; SECTM1 gene; San Francisco; Scientist; Severities; Technology; Time; Training; Training Programs; Training Support; Translational Research; Universities; Vision; Vision research; Visual; animal model development; bench to bedside; biomedical informatics; career; didactic education; drug development; experience; gene therapy; improved; member; multidisciplinary; next generation; programs; public health intervention; responsible research conduct; societal costs; vision science

PROJECT SUMMARY Advances in basic science and technology are occurring at an unprecedented pace. Training the next generation of vision scientists in how to use this knowledge to create new clinical and public health interventions is critical toward reducing the frequency and severity of blindness, a major public fear with devastating individual and societal costs. Unfortunately, ophthalmologists often lack the background to envision how to use recent advances in basic and clinical research to improve patient care, and visual scientists often lack the clinical perspective to identify gaps in patient care that could guide their research. This application proposes to create an institutional K12 mentored experience at the Oregon Health & Science University (OHSU) for junior clinician scientist faculty who are in their first few years out of training. This program's overall goal is to prepare these promising individuals for successful, independent academic and scientific careers in vision science research by providing didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, animal model development and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and has been ranked in the top 5 nationally in NEI- supported research by the Blue Ridge Institute for Medical Research for the past several years. This training program will fill an important gap in education; currently there are no programs at OHSU (or north of San Francisco and west of Chicago) which support the training of clinician-scientists in visual science and ophthalmology. Specifically, we propose a program that will support two K12 recipients at any given time, at different career stages, chosen by an Advisory Committee. Training will consist of four key components: (1) Individualized research projects with mentors and collaborators, (2) A didactic course in the fundamentals of basic, clinical, and translational vision science and access to clinical research programs through the Oregon Clinical & Translational Research Institute (OCTRI), such as the Human Investigations Program (HIP) and Master of Clinical Research Program, (3) Regular research seminars hosted by program faculty and the ophthalmology department, and (4) Training in responsible conduct of research. We believe that this program will provide clinical perspective to trainees with existing backgrounds in basic science, and basic science background to trainees with existing backgrounds in clinical ophthalmology. OHSU is a setting where rigorous training in basic and clinical research through this K12 program will provide promising junior clinician scientist faculty members with the support and background to allow them to realize their career goals of becoming independent vision scientists, clinicians and educators.

项目概要 基础科学和技术正在以前所未有的速度取得进步。训练下一个 一代视觉科学家如何利用这些知识创造新的临床和公共卫生 干预措施对于减少失明的频率和严重程度至关重要，失明是公众的主要担忧 毁灭性的个人和社会成本。不幸的是，眼科医生往往缺乏以下背景： 设想如何利用基础和临床研究的最新进展来改善患者护理和视力 科学家往往缺乏临床视角来确定患者护理方面的差距，从而指导他们的研究。这 申请建议在俄勒冈州健康与科学中心创建机构 K12 指导体验 大学 (OHSU) 为刚毕业几年的初级临床医生科学家教师提供大学 (OHSU)。这 该计划的总体目标是让这些有前途的人为成功、独立的学术和 通过提供教学教育和强化指导研究，促进视觉科学研究的科学职业生涯 多学科环境中的经验。 OHSU 的视觉研究和培训环境非常好 协作和跨学科，在研究从实验室到转化方面提供强大的程序支持 在基因治疗、分子遗传学、药物开发、临床试验、眼科等领域的床旁 成像、动物模型开发和生物医学信息学。该大学拥有顶尖的教育课程 临床眼科和基础视觉科学专业在NEI-中排名全国前5 过去几年支持蓝岭医学研究所的研究。本次培训 该计划将填补教育领域的一个重要空白；目前 OHSU（或圣路易斯北部）没有课程 弗朗西斯科和芝加哥西部）支持视觉科学和临床科学家的培训 眼科。具体来说，我们提出了一项计划，该计划将在任何给定时间支持两名 K12 接受者 不同的职业阶段，由咨询委员会选择。培训将包括四个关键部分：(1) 与导师和合作者一起进行的个性化研究项目，(2) 基础知识的教学课程 基础、临床和转化视觉科学以及通过俄勒冈州获得临床研究项目的机会 临床与转化研究所 (OCTRI)，例如人类研究计划 (HIP) 和 临床研究硕士项目，（3）由项目教师和研究人员定期举办研究研讨会 眼科；以及 (4) 负责任的研究行为培训。我们相信这个计划 将为具有基础科学和基础科学背景的学员提供临床视角 具有临床眼科背景的学员的背景。 OHSU 是一个严格的环境 通过这个 K12 项目进行基础和临床研究培训将培养有前途的初级临床科学家 教师的支持和背景使他们能够实现成为的职业目标 独立视觉科学家、临床医生和教育工作者。