A Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV prevention Behaviors in Diverse Adolescent MSM

MyPEEPS Mobile 改善不同青少年 MSM 的 HIV 预防行为的实用临床试验

• 批准号: 9902191
• 负责人: Robert Garofalo
• 金额: $ 157.58万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9902191
• 关键词: 18 year old; AIDS prevention; AIDS/HIV problem; Address; Adolescent; Affect; Age; Alcohols; Anus; Behavior; Behavior Therapy; Behavioral; Car Phone; Caricatures; Cellular Phone; Chicago; Computers; Devices; Educational Curriculum; Ensure; Ethnic group; Evidence based intervention; FDA approved; Family; Frequencies; Geography; Goals; HIV; HIV Infections; HIV Seronegativity; HIV/STD; Health; Incidence; Individual; Intervention; Knowledge; Latino; Level of Evidence; Life; Link; Literature; Minority Groups; Nature; New York City; Online Systems; Oral; Oral Sex; Participant; Patient Self-Report; Personal Communication; Persons; Pharmaceutical Preparations; Population; Population Group; Populations at Risk; Pragmatic clinical trial; Preventive Intervention; Privacy; Prophylactic treatment; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; Risk; Safe Sex; Sampling; Schedule; Self Efficacy; Sexual Health; Sexual Partners; Site; Structure; Tablets; Testing; Time; Translating; Translations; Travel; Unsafe Sex; Update; Ursidae Family; Work; adolescent men who have sex with men; age group; aged; base; condomless anal sex; condoms; cost; design; efficacy testing; ethnic diversity; ethnic minority population; evidence base; experience; group intervention; high risk; high risk sexual behavior; improved; mHealth; male; member; men who have sex with men; mobile computing; multi-site trial; novel; pilot trial; portability; pre-exposure prophylaxis; primary outcome; racial and ethnic; racial diversity; racial minority; response; scale up; sexual risk behavior; skills; social; theories; user centered design; web-enabled; young men who have sex with men

PROJECT SUMMARY Men who have sex with men (MSM) bear a greater burden of HIV/AIDS than any other population group in the US, comprising only 2% of the population but 56% of individuals living with HIV/AIDS. Although much of the increased incidence in HIV has been reported among young MSM (YMSM), especially among racial and ethnic minority groups, and is linked to high-risk sexual behavior, there remains a dearth of evidence-based HIV prevention interventions for YMSM – and none that address racially/ethnically diverse YMSM. To address this need, our study, in response to RFA-MD-15-012, leverages mobile technology and MyPEEPS, an existing theory-driven, multi-ethnic, group-level, evidence-based intervention for diverse YMSM. MyPEEPS is a manualized curriculum, developed by members of our proposed Investigative team, comprised of 6 modules focusing on key intermediate social and personal factors, including knowledge (e.g., correct way to use a condom), self-efficacy for safer sex, interpersonal communication skills and behavioral skills. MyPEEPS is one of the only HIV prevention interventions in the literature that focuses on diverse adolescent MSM. Long-term sustainability of face-to face, group-level behavioral interventions, such as MyPEEPS, have been problematic for dissemination in at-risk populations, particularly among young racial and ethnic minority groups. In response to this challenge, we propose to translate MyPEEPS from a face-to-face, group-based curriculum to a mobile, responsive-driven web-based platform, accessible by smartphone or other web-enabled devices, to increase accessibility and scalability for diverse YMSM. The ubiquitous nature of mobile phones in daily life, especially among 13-18 year olds, has created opportunities for health interventions in a portable format with enhanced privacy. Using a participatory approach, our study will incorporate user-centered design in the translation of the MyPEEPS intervention onto a mobile platform. MyPEEPS Mobile will be tested in an RCT with racially and ethnically diverse HIV-negative or unknown status YMSM aged 13-18 at four geographically diverse sites: Birmingham, Chicago, New York City, and Seattle, allowing for increased generalizability of findings. The proposed MyPEEPS Mobile intervention is a novel and evidence-driven intervention using mobile technology to deliver HIV prevention information specifically developed for at-risk YMSM. This will be the one of the first studies to test the efficacy of a scaled-up, mobile version of an existing HIV prevention intervention originally developed for, designed by, and piloted for, a diverse group of YMSM. The research team has unique experience and expertise to conduct this important work and has conducted significant preliminary work related to the project goals. If efficacious, the public health impact is large, as the intervention will already be in mobile format which is well-suited for widespread dissemination.

项目摘要 与男性发生性关系的男性（MSM）比其他任何其他人口群体烧伤了艾滋病毒/艾滋病 美国，只有2％的人口，但有56％的人患有艾滋病毒/艾滋病。 虽然很多 据报道，年轻的MSM（YMSM），尤其是种族和族裔中的艾滋病毒发病率增加 少数群体群体，并且与高风险的性行为有关，仍有循证艾滋病毒死亡 YMSM的预防干预措施，也没有针对种族/种族多样的YMSM的预防干预措施。解决这个问题 需要，我们的研究，以回应RFA-MD-15-012，利用移动技术和MyPeeps，一个现有 理论驱动的，多种族，群体级，基于证据的干预措施。 mypeeps是一个 由我们提议的调查团队的成员开发的手动课程，由6个模块组成 专注于关键的中间社会和个人因素，包括知识（例如，正确使用的方法 避孕套），更安全的性别，人际交往能力和行为技巧的自我效能。 mypeeps是一个 文献中唯一专注于潜水青少年MSM的艾滋病毒预防干预措施。长期 面对面的可持续性，小组级行为干预（例如mypeeps）是有问题的 在高危人群中，特别是在年轻的种族和少数民族群体中传播。在 应对这一挑战，我们建议将mypeeps从面对面的基于小组的课程转化为 由智能手机或其他支持Web的设备访问的移动性，响应式驱动的基于Web的平台，可用于 提高潜水员YMSM的可访问性和可伸缩性。手机在日常生活中无处不在的性质， 特别是在13-18岁的年轻人中，以便携式格式为健康干预创造了机会 增强的隐私。使用参与方法，我们的研究将以用户为中心的设计将 将MyPeeps干预翻译到移动平台上。 mypeeps手机将在RCT中进行测试 在四个地理位置上大致和种族多样化的HIV阴性或未知状态YMSM YMSM 13-18岁 潜水地点：伯明翰，芝加哥，纽约市和西雅图，允许提高可推广性 发现。拟议的mypeeps移动干预是一种新颖的循证驱动干预措施 提供专门为处于高危YMSM开发的艾滋病毒预防信息的技术。这将是一个 在测试现有艾滋病毒预防干预措施的扩展，移动版本的效率的第一批研究中 最初是为YMSM的潜水员群体开发，设计和试验的。研究团队有独特的 经验和专家进行这项重要工作，并进行了重要的初步工作 到项目目标。如果高效，公共卫生的影响很大，因为干预已经在移动中 格式非常适合宽度传播。

项目成果

Examining the Information Systems Success (ISS) of a mobile sexual health app (MyPEEPS Mobile) from the perspective of very young men who have sex with men (YMSM).

• DOI: 10.1016/j.ijmedinf.2021.104529
• 发表时间: 2021-09
• 期刊: International journal of medical informatics
• 影响因子: 4.9
• 作者: Cordoba E;Idnay B;Garofalo R;Kuhns LM;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Rodriguez RG;Schnall R
• 通讯作者: Schnall R

Homonegative Victimization and Perceived Stress among Adolescent Sexual Minority Males: The Attenuating Role of Peer and Family Support.

青少年性少数男性的同性受害和感知压力：同伴和家庭支持的减弱作用。

• DOI: 10.1080/19317611.2022.2124341
• 发表时间: 2022
• 期刊: International journal of sexual health : official journal of the World Association for Sexual Health
• 作者: Gordián-Arroyo,Alvin;Schnall,Rebecca;Garofalo,Robert;Kuhns,LisaM;Pearson,Cynthia;Bruce,Josh;ScottBatey,D;Radix,Asa;Belkind,Uri;Hirshfield,Sabina;Hidalgo,MarcoA
• 通讯作者: Hidalgo,MarcoA

Preliminary Results from a Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV Prevention Behaviors in Young Men.

• DOI: 10.3233/shti200444
• 发表时间: 2020-06-16
• 期刊: Studies in health technology and informatics
• 作者: Schnall R;Kuhns L;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Ganzhorn S;Garofalo R
• 通讯作者: Garofalo R

Risk-taking behaviors in adolescent men who have sex with men (MSM): An association between homophobic victimization and alcohol consumption.

• DOI: 10.1371/journal.pone.0260083
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Cordoba E;Garofalo R;Kuhns LM;Pearson C;Bruce J;Batey DS;Radix A;Belkind U;Hidalgo MA;Hirshfield S;Garibay Rodriguez R;Schnall R
• 通讯作者: Schnall R

A Mobile Health Intervention for HIV Prevention Among Racially and Ethnically Diverse Young Men: Usability Evaluation.

• DOI: 10.2196/11450
• 发表时间: 2018-09-07
• 期刊: JMIR mHealth and uHealth
• 影响因子: 5
• 作者: Cho H;Powell D;Pichon A;Thai J;Bruce J;Kuhns LM;Garofalo R;Schnall R
• 通讯作者: Schnall R