Northeast Node of the National Drug Abuse Clinical Trials Network

国家药物滥用临床试验网络东北节点

• 批准号: 9901399
• 负责人: Lisa A. Marsch
• 金额: $ 122.16万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901399
• 关键词: Achievement; Adolescent; Adult; Alcohol or Other Drugs use; American; Analgesics; Behavioral; Caring; Chronic; Clinical; Clinical Trials Network; Collaborations; Communities; Community Networks; Comorbidity; Cost effectiveness research; Criminal Justice; Development; Drug abuse; Drug user; Effectiveness; Evaluation; Funding; Geographic Locations; HIV; HIV risk; Healthcare Systems; Home environment; Hospitals; Individual; Infrastructure; Internet; Intervention; Knowledge; Leadership; Maine; Managed Care; Medical; Mental Health; Mental disorders; Modeling; National Clinical Trials Network; National Institute of Drug Abuse; New Hampshire; Persons; Pharmaceutical Preparations; Pharmacology; Policies; Population; Practical trial; Prevention; Primary Health Care; Principal Investigator; Public Health; Recovery; Research; Research Infrastructure; Research Support; Resources; Risk; Risk Behaviors; Role; Rural Community; Sample Size; Sampling; Schools; Science; Seminal; Services; Site; Smoker; Substance Use Disorder; Substance abuse problem; System; Technology; Therapeutic; Time; Tranquilizing Agents; Vermont; Veterans; Work; Youth; addiction; adolescent substance use; aged; base; behavioral health; care coordination; care systems; chronic pain patient; college; effectiveness trial; evidence base; illicit drug use; implementation research; insight; marijuana use; medical specialties; opioid use disorder; payment; prescription opioid; primary care setting; programs; provider networks; ranpirnase; research and development; rural area; rural healthcare; science education; screening; service delivery; substance abuse treatment; synergism; technology validation; therapy development; tool

Project Summary/Abstract We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 “Center of Excellence” that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectiveness, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth – both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.

项目摘要/摘要 我们建议建立NIDA临床试验网络（CTN）的新节点 - 东北节点 跨越新罕布什尔州，佛蒙特州和缅因州的粗糙社区。该节点将基于 达特茅斯学院与多个大型提供商网络合作，这些网络涵盖400多个成人和/或 青少年的一般医疗伙伴，一系列成瘾性计划和国家行为 卫生托管护理合作伙伴。达特茅斯（Dartmouth）是该节点的理想住所，因为它也是NIDA-的家 资助技术与行为健康中心（CTBH），P30使用科学的“卓越中心” 为基于技术的开发，评估和战略实施（Web，移动）提供信息 针对药物使用障碍（SUD）和相关问题的治疗工具（包括艾滋病毒风险行为和 精神病合并症）。 CTBH由Lisa Marsch博士领导，他还将担任首席研究员 在建议的CTN节点上。我们的团队通过提高质量，成就空间和 科学研究的影响着重于技术在SUD和行为健康治疗中的应用。 我们的团队在SUD干预开发的各个阶段都有专业知识，从可接受性，可接受性， 有效性，有效性，有效性（包括多站点有效性试验），成本效益和 在许多情况下的实施研究，包括成瘾和心理健康专业计划，医学 专业计划，医院，学校，刑事司法机构和初级保健。这项工作包括 关于将SUD干预措施整合到粗糙医疗保健系统中的半研究。这项工作已经 由多种人口进行，包括慢性吸毒者，吸烟者，退伍军人，慢性疼痛 患者，有艾滋病毒的风险的患者以及患有肥皂和精神疾病的患者。我们的小组有 青年研究方面的特殊专业知识，包括筛查和评估，预防，治疗， 恢复支持和对青少年的护理协调 - 包括几条专注于 大麻使用和处方阿片类药物使用障碍。该提议的目的是（1）扩展 NIDA CTN通过启动CTN的东北节点，从而向农村地区的新州进行 扩大我们与初级保健和其他社区治疗伙伴的合作，以识别和 （2）支持和发展生产性研究议程 特别关注CTN试验，该试验集中利用基于技术的工具和/或优先重点 关于东北节点内的青年以及国家CTN内的领导和咨询角色 社区，以及（3）开发和支持基础设施，以增强双向交际 CTBH和CTN之间的知识和资源共享。这些活动将为关键科学提供信息 关于粗糙的医疗保健系统中与物质使用相关需求和优先级的发现和见解 以及基于技术的干预措施在各种社区系统中的有效性。