Treatment Development & Evaluation Core

治疗开发

• 批准号: 10624448
• 负责人: Lisa A. Marsch
• 金额: $ 35.27万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624448
• 关键词: AIDS prevention; Acceleration; Address; Adherence; Adolescent; Adult; Advanced Development; Agitation; Applications Grants; Area; Assessment tool; Behavior Therapy; Behavior monitoring; Cellular Phone; Clinical; Collection; Communities; Consultations; Data; Decision Making; Development; Diagnosis; Diagnostic; Digital biomarker; Doctor of Philosophy; Education; Educational Activities; Educational workshop; Effectiveness; Ethics; Etiology; Evaluation; Evidence based treatment; Exercise; Experimental Designs; Faculty; Fostering; Funding; Goals; Grant; Health; Heart Rate; Individual; Intervention; Location; Measurement; Mental Health; Mentors; Mentorship; Methods; Minority; Minority Groups; Minority Health Research; Outcome; Outcome Study; Paper; Participant; Persons; Pharmacotherapy; Phenotype; Physiologic Monitoring; Population; Population Heterogeneity; Postdoctoral Fellow; Privacy; Process; Process Assessment; Public Health; Publishing; Reduce health disparities; Relapse; Research; Research Personnel; Research Priority; Research Project Grants; Resource Sharing; Resources; Risk; Science; Services; Sleep disturbances; Specificity; Students; Substance Use Disorder; Targeted Research; Technology; Therapeutic; Therapeutic Research; Time; Training; Treatment Protocols; Underrepresented Minority; adaptive intervention; cost; digital; digital assessment; digital health; digital treatment; dual diagnosis; evidence base; health assessment; improved; innovation; intervention effect; novel; personalized therapeutic; phenotypic data; physical conditioning; recruit; social contact; substance use; substance use treatment; success; therapy design; therapy development; usability; wearable sensor technology; webinar

TREATMENT DEVELOPMENT AND EVALUATION CORE PROJECT SUMMARY Digital therapeutics hold great promise in overcoming the substantial challenges in accessing high quality, empirically supported treatments for substance use disorders (SUDs) and co-occurring mental or physical health conditions (CODs). Digital innovations can enhance the potency of existing interventions, extend their reach, and reduce costs. Digital biomarkers from behavioral and physiological monitoring using smartphones and wearable sensors (i.e., passive sensing) can improve specificity of assessment processes that in turn can provide personalized targets to optimize interventions. Supporting the development of digital therapeutics is vital, as most persons with SUDs do not receive SUD treatment, and of those who do receive treatment, only a minority of treatments are evidence-based. Over the past 9 years, the Treatment Development and Evaluation (TDE) Core has supported activities that enhance and expedite research on an array of technologies that can improve treatment delivery. Our Core affiliates’ research has advanced the feasibility, acceptability, usability, and efficacy of innovative digital health assessment tools and interventions for multiple types of SUDs among diverse populations. These projects have also improved our understanding of developmental, and maintaining factors, and mechanisms of change for SUDs. In the proposed renewal period, the TDE Core will continue to enhance the quality, efficiency, and impact of research projects among an interdisciplinary expert faculty. The Core will continue with, and expand activities for, sharing resources among CTBH affiliates and the greater scientific and clinical communities (Aim 1), and provide mechanisms to support the acceleration and accumulation of science that will enhance our understanding of factors that can optimize digital therapeutics for SUDs and CODs (Aim 2). These efforts will embrace the 5 new CTBH priorities (e.g., scaling of digital therapeutics, digital measurement to inform personalized just-in-time adaptive interventions (JITAIs), integration of CODs and transdiagnostic mechanisms and interventions, digital health ethics, and inclusion of underrepresented minority populations). For example, we will enhance our consultation services for preparing competitive grant applications by expanding the array of Advisors with expertise in the priority areas, and will refine the focus and enhance the intensity of our educational activities by developing and delivering webinars, tutorials, and cross-Core workshops that provide in-depth training on high priority research targets. The Core will also engage affiliates with active or pending digital health projects to include additional research aims that address our new priorities. e.g., add common metrics of outcomes related to scaling, mechanisms of change, or transdiagnostic processes; include passive sensing assessment to collect digital phenotyping data that may relate to substance use or relapse; and assess CODs in SUD projects to evaluate how they moderate intervention effects and how transdiagnostic interventions impact outcomes. These efforts will accelerate the state-of-the science of digital therapeutics for SUDs and related conditions across diverse populations.

治疗开发和评估核心项目摘要 数字疗法在克服获得高质量的重大挑战方面有着巨大的希望， 经验支持药物使用障碍（SUD）和同时发生的精神或身体的治疗方法 健康状况（COD）。数字创新可以增强现有干预措施的效力，扩展其 达到并降低成本。使用智能手机的行为和物理监控的数字生物标志物 和可穿戴传感器（即被动灵敏度）可以提高评估过程的特异性，而评估过程又可以 提供个性化目标以优化干预措施。支持数字疗法的发展是 至关重要的，因为大多数肥皂水没有接受SUD治疗，而在接受治疗的人中，只有一个 少数治疗是基于证据的。在过去的9年中，治疗开发和评估 （TDE）Core支持了对一系列技术的研究和加快研究的活动 改善治疗交付。我们的核心分支机构的研究提高了可行性，可接受性，可用性， 以及创新的数字健康评估工具和干预措施的多种类型SUD的干预措施 多样化的人口。这些项目还提高了我们对发展和维护的理解 因素和SUD的变化机制。在拟议的续签期间，TDE核心将继续 提高跨学科专家教师研究项目的质量，效率和影响。 核心将继续进行并扩大活动，以共享CTBH分支机构之间的资源和更大的活动 科学和临床社区（AIM 1），并提供支持加速和 科学的积累将增强我们对可以优化数字疗法的因素的理解 泡沫和鳕鱼（AIM 2）。这些努力将涵盖5个新的CTBH优先事项（例如，数字规模扩展 治疗，数字测量，以告知个性化的即时自适应干预措施（Jitais）， COD和经诊断机制和干预措施，数字健康道德以及包含的集成 代表性不足的少数民族人口）。例如，我们将增强我们的咨询服务 通过在优先领域提供专业知识的一系列顾问来扩展竞争性赠款申请，并将 通过开发和提供网络研讨会，完善重点并提高我们的教育活动的强度， 教程和跨核研讨会，可为高优先级研究目标提供深入的培训。核心 还将与主动或正在等待的数字健康项目一起参与分支机构，以包括其他研究目的 解决我们的新优先事项。例如，添加与缩放，变化机制相关的结果的共同指标， 或经诊断过程；包括被动灵敏度评估，以收集可能的数字表型数据 与物质使用或继电器有关；并评估SUD项目中的COD，以评估它们如何现代化 干预效果以及转诊干预措施如何影响结果。这些努力将加速 跨潜水员人群的SUD和相关状况的数字疗法的最新科学。