Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for Progress

里奥格兰德河谷阿尔茨海默病少数族裔老龄化研究资源中心：合作促进进步

• 批准号: 9768305
• 负责人: Gladys E. Maestre
• 金额: $ 65.47万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768305
• 关键词: Achievement; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavior; Behavioral; Behavioral Research; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cognitive; Communities; Complex; Data Collection; Development; Diabetes Mellitus; Diagnosis; Discipline; Discrimination; Disease; Economic Burden; Educational Background; Elderly; Ethnic group; Exhibits; Exposure to; Faculty; Family; Fostering; Funding; Genetic; Goals; Growth; Health; Health Personnel; Health Promotion; Healthcare; Healthcare Systems; High Prevalence; Hispanic-serving Institution; Hispanics; Individual; Infrastructure; Institutes; Institution; Intervention; Kansas; Knowledge; Latino; Lead; Leadership; Life Style; Measurement; Mentors; Mentorship; Mexico; Minority; Minority-Serving Institution; Modeling; Neighborhood Health Center; Neuropsychology; Neurosciences; Obesity; Pathway interactions; Personal Satisfaction; Pilot Projects; Population; Positioning Attribute; Poverty; Prevention; Public Health; Research; Research Personnel; Research Training; Resources; Risk; Risk Factors; Social Change; Source; South Texas; Statistical Data Interpretation; Testing; Texas; Textiles; Time; Training; Training Programs; Training and Education; Underrepresented Groups; Universities; Vision; Washington; career; career development; cohort; community organizations; early life adversity; education research; educational atmosphere; evidence base; experience; health disparity; health economics; improved; innovation; minority health; multidisciplinary; neuroimaging; programs; racial and ethnic; recruit; social; sociodemographics; socioeconomics; trait; working group

Summary OVERALL Alzheimer´s disease (AD) is an aging-associated disorder that disproportionately impacts Hispanics/Latinos, who exhibit AD rates 1.5 times higher and average onset 7 years earlier than do older whites. Predicted growth of the US Hispanic population, particularly faster in Texas, portends further exacerbation of the disproportion- ate health and economic burdens of elevated AD in Hispanics. There is a shortage of researchers focused on AD and related disorders (ADRD) in Hispanics, particularly from underrepresented racial/ethnic groups. To overcome these barriers, the proposed AD Resource Center for Minority Aging Research (AD-RCMAR) at the University of Texas Rio Grande Valley (UTRGV), one of the nation's largest Hispanic-serving institutions, will combine evidence-based mentoring and support mechanisms to develop and promote a first-rate regional and national cadre of researchers, particularly from under-represented groups, to analyze the complex mecha- nisms and interacting factors that contribute to Hispanics' disparate vulnerabilities to AD. The Center will sup- port identification of pathways and developmental time points at which changes in social circumstances and behavior can exert the largest favorable impacts on prevention and progression of AD among Hispanics. The UTRGV AD-RCMAR will exploit its unique resources to develop infrastructure and data collections that will at- tract and support researchers from multiple disciplines and at different scientific career stages, and allow them to conduct research aimed at reducing the impacts of AD on Hispanics. The socio-demographic profile of UTRGV reflects that of its local community, positioning the Center uniquely to advance studies of disparities in health and health care and contribute innovative solutions to improve minorities' health. We will achieve the Center's goals via 4 specific aims: 1) to identify, engage, mentor, and provide high-quality training and individu- alized career development support to outstanding faculty, especially from underrepresented groups; 2) to sup- port innovative, high-impact multidisciplinary pilot projects; 3) to provide expertise and resources for culturally- sensitive measurement and analysis of cognitive risk factors in older Hispanics, including behavioral, neuro- psychological, neuroimaging, and cardiovascular and genetic traits; and 4) to create the necessary expertise and resources to establish longitudinal research cohorts of older Hispanics and their families. We will achieve these aims through the creation of 4 Cores (Administrative; Research Education; Analysis; and Community Liaison/Recruitment) to support AD research. The Center will build upon the experience of investigators at the UTRGV Institute of Neuroscience and collaborators at the South Texas Diabetes & Obesity Institute, and Washington University's AD Research Center.

总结总结 阿尔茨海默氏病（AD）是一种与衰老相关的疾病，对西班牙裔/拉丁裔的影响不成比例 他们暴露于广告的率比老年白人早7年提高了1.5倍和平均发病率。预测增长 美国西班牙裔人口，尤其是在德克萨斯州更快的人口 西班牙裔美国人的健康和经济燃烧。研究人员的重点不足 西班牙裔美国人中的广告和相关疾病（ADRD），特别是来自代表性不足的种族/族裔群体。到 克服这些障碍，拟议的少数民族老化研究中心（AD-RCMAR）在 德克萨斯大学里奥格兰德大学（UTRGV）是美国最大的西班牙裔美国人服务机构之一 结合基于证据的心理和支持机制，以发展和促进一流的区域和 全国研究人员，特别是来自代表性不足的群体的研究人员，分析了复杂的机甲 促成西班牙裔不同脆弱性广告的Nism和相互作用的因素。中心将占用 港口识别途径和发展时间点，在社会环境中发生变化和 行为可以对西班牙裔美国人的预防和AD发展产生最大的有利影响。这 UTRGV AD-RCMAR将利用其独特的资源来开发基础架构和数据收集，以 从多个学科和不同的科学职业阶段进行研究和支持研究人员，并允许他们 进行旨在减少AD对西班牙裔影响的研究。的社会人口统计学概况 UTRGV反映了当地社区的，将中心定位为独特的，以推动对分布的研究 卫生和医疗保健，并为改善少数群体的健康做出创新解决方案。我们将实现 通过4个特定目标中心的目标：1）识别，参与，精神并提供高质量的培训和个人 - 对杰出教职员工的职业发展支持，特别是来自代表性不足的团体； 2）sup- 港口创新，高影响力的多学科试点项目； 3）为文化提供专业知识和资源 - 对较旧的西班牙裔的认知风险因素的敏感测量和分析，包括行为，神经 - 心理，神经影像学以及心血管和遗传特征； 4）创建必要的专业知识 以及建立纵向研究人群及其家人的资源。我们将实现 这些目标是通过创建4个核心（行政；研究教育；分析；社区 联络/招聘）支持广告研究。该中心将基于调查人员的经验 南德克萨斯州糖尿病与肥胖研究所的UTRGV神经科学研究所和合作者 华盛顿大学的广告研究中心。