Mindfulness Meditation Training in Lonely Older Adults

孤独老年人的正念冥想训练

基本信息

批准号：
9898542
负责人：
John David Creswell
金额：
$ 0.71万
依托单位：
CARNEGIE-MELLON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9898542
关键词：
Address Aftercare Age Alzheimer&apos s Disease Behavior Therapy Biological Markers Blood specimen Buffers C-reactive protein Cardiovascular Diseases Cellular Phone Chronic Control Groups Disease Distress Ecological momentary assessment Elderly Frequencies Gene Expression Health Health education Human IL6 gene Individual Inflammation Inflammatory Interleukin-6 Intervention Intervention Studies Laboratories Life Loneliness Measures Mental Depression Mental Health Mindfulness Training Modeling Morbidity - disease rate Participant Perception Pilot Projects Population Premature Mortality Public Health Questionnaires Randomized Randomized Controlled Trials Research Risk Risk Factors Sample Size Sampling Smoking Social Interaction Structure Testing Time Training Training and Education United States Work active method base circulating biomarkers disorder risk experience follow-up improved inflammatory marker innovation mindfulness mindfulness meditation mindfulness-based stress reduction mortality mortality risk negative affect novel patient population physical conditioning post intervention programs psychologic psychological distress response social success treatment program

项目摘要

The broad aim of this research is to evaluate whether mindfulness meditation training reduces loneliness, improves social relationship functioning, and improves biomarkers of inflammation in lonely older adults. Lonely older adults (aged 55+ years) are a population that is increasing in size in the United States relative to other segments of the population and they have significantly elevated health risks (e.g., increased inflammation, cardiovascular disease, depression, and premature mortality). Interventions that can reduce loneliness have significant potential to reduce the elevated morbidity and premature mortality in this growing but understudied patient population. Previous RCT studies that have attempted to reduce loneliness in older adults have had limited success. In a pilot study, we found that an 8-week Mindfulness-Based Stress Reduction (MBSR) program reduced loneliness and inflammation in lonely older adults (Creswell et al., 2012). This proposal describes an innovative and well-controlled RCT of MBSR in lonely older adults (N=188), comparing MBSR to a structurally equivalent 8-week Health Education Program (HEP) and a no treatment control condition. Participants will complete questionnaires, daily experience sampling (using pre-programmed smartphones), and provide blood samples at baseline, post-treatment, and 3-month follow-up. This proposed study will test three specific aims that are guided by a novel conceptual model: (1) mindfulness meditation training reduces loneliness; (2) the effects of mindfulness meditation training on loneliness are explained by reductions in relational distress in daily life interactions; and (3) mindfulness meditation training reduces biomarkers of inflammatory disease risk that are elevated in lonely older adults (pro-inflammatory gene expression, C Reactive Protein, and Interleukin-6). The information provided by this study has the potential to: (a) identify a novel treatment for loneliness in older adults; (b) reveal a social psychological mechanism for this effect (i.e., reductions in daily life relational distress); and to (c) describe the health protective consequences of this treatment on inflammatory disease risk in this at-risk patient population.

这项研究的主要目的是评估正念冥想训练是否有效减少孤独感，改善社会关系功能，并改善生物标志物孤独老年人的炎症。孤独的老年人（55 岁以上）是一个群体相对于其他人口群体，美国的人口规模正在增加并且它们的健康风险显着升高（例如，炎症增加，心血管疾病、抑郁症和过早死亡）。干预措施可以减少孤独感对于降低发病率升高具有巨大的潜力在这个不断增长但研究不足的患者群体中，过早死亡的情况。先前的随机对照试验试图减少老年人孤独感的研究取得了有限的成功。在一项试点研究中，我们发现为期 8 周的正念减压 (MBSR) 该计划减少了孤独老年人的孤独感和炎症（Creswell 等，2012）。该提案描述了针对孤独老年人的 MBSR 的创新且控制良好的随机对照试验成人 (N=188)，将 MBSR 与结构上等效的 8 周健康教育进行比较程序（HEP）和无治疗对照条件。参与者将完成问卷调查、每日经验抽样（使用预编程的智能手机）以及提供基线、治疗后和 3 个月随访时的血液样本。这个提议研究将测试由新颖概念模型指导的三个具体目标：(1) 正念冥想训练可以减少孤独感； (2)正念的作用冥想训练对孤独的影响是通过日常关系痛苦的减少来解释的。生活互动； (3) 正念冥想训练可减少以下生物标志物孤独的老年人患炎症性疾病的风险较高（促炎症基因表达、C 反应蛋白和白细胞介素 6）。本研究提供的信息有潜力： (a) 找到一种治疗老年人孤独感的新方法； (b) 揭示这种效应的社会心理机制（即日常生活关系的减少）遇险）； (c) 描述这种治疗对健康的保护作用该高危患者群体的炎症性疾病风险。