Mindfulness Meditation Training in Lonely Older Adults

孤独老年人的正念冥想训练

• 批准号: 9139430
• 负责人: John David Creswell
• 金额: $ 58.35万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9139430
• 关键词: Address; Affective; Aftercare; Age; Alzheimer' s Disease; Behavior Therapy; Biological Markers; Blood specimen; Buffers; C-reactive protein; Cardiovascular Diseases; Cellular Phone; Control Groups; Disease; Distress; Ecological momentary assessment; Elderly; Frequencies; Funding Opportunities; Gene Expression; Health; Health education; Human; IL6 gene; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Intervention Studies; Laboratories; Life; Loneliness; Measures; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Parents; Participant; Perception; Pilot Projects; Population; Premature Mortality; Public Health; Questionnaires; Randomized; Randomized Controlled Trials; Research; Research Personnel; Risk; Risk Factors; Sample Size; Sampling; Smoking; Social Interaction; Staging; Testing; Time; Training; United States; Work; active method; aged; base; circulating biomarkers; disorder risk; experience; follow-up; improved; improved functioning; innovation; mindfulness; mindfulness meditation; mindfulness-based stress reduction; mortality; novel; patient population; physical conditioning; post intervention; programs; psychologic; psychological distress; response; social; success; treatment program

 DESCRIPTION (provided by applicant): The proposed project is a new submission by an Early Stage Investigator for a Parent R01 (Funding Opportunity Announcement PA-13-302). The broad aim of this research is to evaluate whether mindfulness meditation training reduces loneliness, improves social relationship functioning, and improves biomarkers of inflammation in lonely older adults. Lonely older adults (aged 65-93 years) are a population that is increasing in size in the United States relative to other segments of the population and they have significantly elevated health risks (e.g., increased inflammation, cardiovascular disease, depression, and premature mortality). Interventions that can reduce loneliness have significant potential to reduce the elevated morbidity and premature mortality in this growing but understudied patient population. Previous RCT studies that have attempted to reduce loneliness in older adults have had limited success. In a pilot study, we found that an 8-week Mindfulness-Based Stress Reduction (MBSR) program reduced loneliness and inflammation in lonely older adults (Creswell et al., 2012). This proposal describes an innovative and well-controlled RCT of MBSR in lonely older adults (N=188), comparing MBSR to a structurally equivalent 8-week Health Education Program (HEP). Participants will complete questionnaires, daily experience sampling (using pre-programmed smartphones), and provide blood samples at baseline, post-treatment, and 3-month follow-up. This proposed study will test three specific aims that are guided by a novel conceptual model: (1) mindfulness meditation training reduces loneliness; (2) the effects of mindfulness meditation training on loneliness are explained by reductions in relational distress in daily life interactions; and (3) mindfulness meditation training reduces biomarkers of inflammatory disease risk that are elevated in lonely older adults (pro-inflammatory gene expression, C Reactive Protein, and Interleukin-6). The information provided by this study has the potential to: (a) identify a novel treatment for loneliness in older adults; (b) reveal a social psychological mechanism for this effect (i.e., reductions in daily life relational distress); and to (c) describe the health protective consequences of this treatment on inflammatory disease risk in this at-risk patient population.

 描述（由申请人提供）：拟议项目是早期研究人员为母公司 R01 提交的新项目（资助机会公告 PA-13-302）。 这项研究的主要目的是评估正念冥想训练是否可以减少孤独感、改善社会关系功能并改善孤独老年人（65-93 岁）的炎症生物标志物。与其他人群相比，美国人口的健康风险显着升高（例如，炎症、心血管疾病、抑郁症和过早死亡率增加），可以减少孤独感的干预措施对于降低较高的发病率和过早死亡率具有巨大的潜力。这成长的但之前试图减少老年人孤独感的随机对照试验研究取得了有限的成功，在一项试点研究中，我们发现为期 8 周的正念减压 (MBSR) 计划可以减少孤独老年人的孤独感和炎症。成人（Creswell 等，2012）该提案描述了一项针对孤独老年人（N=188）的创新且控制良好的 MBSR 随机对照试验，将 MBSR 与结构上等效的 8 周健康进行比较。教育计划 (HEP)。参与者将完成问卷、每日经验采样（使用预先编程的智能手机），并提供基线、治疗后和 3 个月随访时的血液样本。以一种新颖的概念模型为指导：（1）正念冥想训练可以减少孤独感；（2）正念冥想训练对孤独感的影响可以通过减少日常生活互动中的关系痛苦来解释；（3）正念冥想训练可以减少孤独感的生物标志物；孤独的老年人患炎症性疾病的风险较高成人（促炎基因表达、C 反应蛋白和白细胞介素 6）。本研究提供的信息有可能：(a) 确定一种治疗老年人孤独的新方法；(b) 揭示一种社会心理机制。 (c) 描述这种治疗对高危患者群体的炎症性疾病风险的健康保护作用。