Mindfulness Meditation Training in Lonely Older Adults

孤独老年人的正念冥想训练

• 批准号: 8861344
• 负责人: John David Creswell
• 金额: $ 57.57万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8861344
• 关键词: Address; Affective; Aftercare; Age; Alzheimer' s Disease; Behavior Therapy; Biological Markers; Blood specimen; Buffers; C-reactive protein; Cardiovascular Diseases; Cellular Phone; Control Groups; Disease; Distress; Ecological momentary assessment; Elderly; Frequencies; Funding Opportunities; Gene Expression; Health; Health education; Human; IL6 gene; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Intervention Studies; Laboratories; Life; Loneliness; Measures; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Parents; Participant; Perception; Pilot Projects; Population; Premature Mortality; Public Health; Questionnaires; Randomized; Randomized Controlled Trials; Relative (related person); Research; Research Personnel; Risk; Risk Factors; Sample Size; Sampling; Smoking; Social Interaction; Staging; Testing; Time; Training; United States; Work; active method; aged; base; disorder risk; experience; follow-up; improved; improved functioning; inflammatory marker; innovation; mindfulness; mindfulness meditation; mindfulness-based stress reduction; mortality; novel; patient population; physical conditioning; post intervention; programs; psychologic; psychological distress; response; social; success; treatment program

 DESCRIPTION (provided by applicant): The proposed project is a new submission by an Early Stage Investigator for a Parent R01 (Funding Opportunity Announcement PA-13-302). The broad aim of this research is to evaluate whether mindfulness meditation training reduces loneliness, improves social relationship functioning, and improves biomarkers of inflammation in lonely older adults. Lonely older adults (aged 55+ years) are a population that is increasing in size in the United States relative to other segments of the population and they have significantly elevated health risks (e.g., increased inflammation, cardiovascular disease, depression, and premature mortality). Interventions that can reduce loneliness have significant potential to reduce the elevated morbidity and premature mortality in this growing but understudied patient population. Previous RCT studies that have attempted to reduce loneliness in older adults have had limited success. In a pilot study, we found that an 8-week Mindfulness-Based Stress Reduction (MBSR) program reduced loneliness and inflammation in lonely older adults (Creswell et al., 2012). This proposal describes an innovative and well-controlled RCT of MBSR in lonely older adults (N=188), comparing MBSR to a structurally equivalent 8-week Health Education Program (HEP) and a no treatment control condition. Participants will complete questionnaires, daily experience sampling (using pre-programmed smartphones), and provide blood samples at baseline, post-treatment, and 3-month follow-up. This proposed study will test three specific aims that are guided by a novel conceptual model: (1) mindfulness meditation training reduces loneliness; (2) the effects of mindfulness meditation training on loneliness are explained by reductions in relational distress in daily life interactions; and (3) mindfulness meditation training reduces biomarkers of inflammatory disease risk that are elevated in lonely older adults (pro-inflammatory gene expression, C Reactive Protein, and Interleukin-6). The information provided by this study has the potential to: (a) identify a novel treatment for loneliness in older adults; (b) reveal a social psychological mechanism for this effect (i.e., reductions in daily life relational distress); and to (c) describe the health protective consequences of this treatment on inflammatory disease risk in this at-risk patient population.

 描述（由申请人提供）：拟议的项目是一位早期研究者为家长 R01 提交的新材料（资助机会公告 PA-13-302）。这项研究的主要目标是评估正念冥想训练是否可以减少孤独感，改善社会关系功能，并改善孤独老年人（55 岁以上）的炎症生物标志物 相对于其他人群，美国的孤独老年人（55 岁以上）人口规模正在增加。而且它们显着增加了健康风险（例如，增加炎症、心血管疾病、抑郁和过早死亡），在这一不断增长但尚未得到充分研究的患者群体中，可以减少孤独感的干预措施具有显着降低发病率和过早死亡率上升的潜力。在一项试点研究中，我们发现为期 8 周的正念减压 (MBSR) 计划可以减少孤独老年人的孤独感和炎症（Creswell 等人）。 al., 2012)。该提案描述了针对孤独老年人 (N=188) 的创新且控制良好的 MBSR 随机对照试验，将 MBSR 与结构上等效的 8 周健康教育计划 (HEP) 和无治疗对照条件进行比较。参与者将完成调查问卷、每日经验采样（使用预编程的智能手机），并在基线、治疗后和 3 个月随访时提供血液样本。这项拟议的研究将测试以新颖概念为指导的三个具体目标。模型：（1）正念冥想训练可以减少孤独感；（2）正念冥想训练对孤独感的影响可以通过减少日常生活互动中的关系困扰来解释；（3）正念冥想训练可以减少炎症性疾病风险升高的生物标志物。孤独的老年人（促炎基因表达、C 反应蛋白和白细胞介素 6） 本研究提供的信息有可能： (a) 确定一种治疗老年人孤独的新方法；这种效应的社会心理机制（即日常生活关系困扰的减少）；以及 (c) 描述这种治疗对该高危患者群体的炎症性疾病风险的健康保护作用。