DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM

深南转化研究指导职业发展计划

• 批准号: 9892162
• 负责人: Kenneth G Saag
• 金额: $ 104.32万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-06 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9892162
• 关键词: Address; Affect; Area; Cessation of life; Clinical; Clinical Informatics; Competence; Deep South; Development; Discipline; Disease; Educational Curriculum; Extramural Activities; Faculty; Fostering; Funding; Future; Goals; Grant; Healthcare; Imagination; Individual; Infrastructure; Institution; Intuition; Label; Logic; Mentors; Methodology; Outcomes Research; Program Development; Research; Research Personnel; Science; Thinking; Training; Training and Infrastructure; Translational Research; base; career; career development; clinical practice; cohort; drug development; drug discovery; early-career faculty; experience; health care disparity; health disparity; improved; innovation; multidisciplinary; peer; recruit; skills; translational scientist

We propose the Deep South Translational Research Mentored Career Development Program KL2 to focus on the growing gap between research and the translation of research into clinical practice that has been labeled the “valley of death”. Our Partner Network brings existing training infrastructure, ongoing partnerships, and complementary research expertise in diseases and disparities that are disproportionately represented within an area of the southeastern US known as the “Deep South”. We aim to create a career development program that fosters “team science” and instills scholars with mastery of translational research (TR) core competencies through an intensive curriculum that will nurture “translational thinking” by helping Scholars use logic, imagination, intuition, and systemic reasoning, to examine potential solutions to diseases and conditions that disproportionately affect the Deep South. Over the grant period, we intend to provide enhanced training for 18 early career faculty scholars who will be supported by a collaborative research base (109 mentors) supported by more than $315 million in extramural funding. Our overall goal for this career development program is to facilitate new, and expand existing, innovative opportunities to train early career faculty across the T1-TR spectrum in areas such as drug discovery and development, integrative “omics”, clinical informatics, and outcomes research aimed at addressing disease and health care disparities that disproportionately affect the Deep South. We will mentor these early career investigators towards becoming academic leaders within our CCTS Partner Network and nationally. Our specific aims are to: 1) Identify, recruit, and cultivate a diverse cohort of early career faculty investigators across the Partner Network; 2) Enhance the personalized career development of translational scientists from a broad range of clinical and methodological disciplines through individual, peer, and team mentoring particularly focused on future grant development and grant submission support to assist in the transition towards an independent research career; 3) Provide a curriculum and collaborative, multidisciplinary experiential training in translational research incorporating a spectrum of clinical disorders, with emphasis on prevalent diseases and health disparities in the US Deep South; 4) Advance mentoring and team building skills of faculty to foster “team science” and continue the expansion of cross-institutional training experiences for KL2 Scholars and other early career investigators; The Deep South Translational Research KL2 will provide new and expand existing infrastructure across our regional partners for career development, to recruit and train individuals with significant potential to be highly successful translational researchers, and to mentor them toward becoming academic leaders at our institutions and nationally, and ultimately to improve healthcare in the Deep South.

我们提议以深南转化研究为指导的职业发展 KL2 计划将重点关注研究与研究转化为临床之间日益扩大的差距 我们的合作伙伴网络带来了现有的培训基础设施， 持续的伙伴关系以及疾病和差异方面的互补研究专业知识 我们的目标是在美国东南部被称为“南方腹地”的地区占据不成比例的比例。 创建一个职业发展计划，促进“团队科学”并向学者灌输掌握 通过强化课程培养转化研究（TR）核心能力，培养“转化研究” 思考”，帮助学者运用逻辑、想象力、直觉和系统推理来检验潜力 在资助期内，我们为影响南方腹地的疾病和状况提供了解决方案。 打算为 18 名早期职业教师学者提供强化培训，他们将得到 合作研究基地（109 名导师）得到超过 3.15 亿美元的外部资金支持。 该职业发展计划的总体目标是促进新的并扩展现有的创新 在药物发现等领域培训跨 T1-TR 谱系的早期职业教师的机会 和开发、综合“组学”、临床信息学和结果研究，旨在 我们将解决对南方腹地影响尤为严重的疾病和医疗保健差距。 这些早期职业调查员将成为我们 CCTS 合作伙伴中的学术领导者 我们在全国范围内的具体目标是： 1) 识别、招募和培养多元化的早期人才。 合作伙伴网络中的职业教师调查员；2) 增强个性化职业发展； 来自广泛的临床和方法论学科的转化科学家通过个人、同行、 和团队指导特别关注未来的赠款开发和赠款提交支持，以协助 向独立研究生涯的过渡；3）提供课程和协作， 结合一系列临床疾病的转化研究的多学科体验式培训， 重点关注美国南部腹地的流行疾病和健康差异 4) 提前指导； 和教师团队建设技能，以培养“团队科学”并继续扩展跨机构 KL2 学者和其他早期职业调查员的培训经验； Research KL2 将为我们的区域合作伙伴提供新的和扩展现有的基础设施 职业发展，招募和培训具有巨大成功潜力的个人 转化研究人员，并指导他们成为我们机构的学术领导者 在全国范围内，并最终改善南方腹地的医疗保健。