Early life exposure to the natural, built, and social environments and incident hypertension

生命早期接触自然、建筑和社会环境和高血压事件

• 批准号: 9764825
• 负责人: Francine Laden
• 金额: $ 66.67万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764825
• 关键词: 15 year old; Address; Adolescence; Adult; Age; Age-Years; Air Pollution; American; American Heart Association; Attenuated; Behavior; Behavioral; Biological; Blood Pressure; Cardiology; Cardiovascular Diseases; Characteristics; Chemicals; Child; Child Abuse; Childhood; Complex; Data; Detection; Development; Diet; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Evaluation; Exposure to; Family; Female; Future; Gender; Goals; Guidelines; Health; Humidity; Hypertension; Incidence; Individual; Joints; Life Style; Light; Mediating; Mental Health; Modification; Mothers; Neighborhoods; Noise; Nurses' Health Study; Obesity; Ozone; Parent-Child Relations; Participant; Particulate Matter; Pathway interactions; Physical activity; Policies; Pollution; Population; Population Density; Positioning Attribute; Prevalence; Prevention; Prevention Guidelines; Process; Prospective cohort study; Race; Reporting; Resources; Risk; Risk Assessment; Risk Factors; Role; Social Environment; Socioeconomic Status; Symptoms; Temperature; Time; Ultraviolet Rays; United States; Update; Violence; Vitamin D Deficiency; Woman; base; built environment; coarse particles; college; demographics; early life exposure; environmental agent; experience; male; men; modifiable risk; offspring; prospective; public health priorities; public health relevance; sex; social; stressor; walkability; young adult

PROJECT SUMMARY Over a third of adults in the United States were previously estimated to have hypertension, defined since 2003 as a blood pressure of 140/90mm Hg. This prevalence is expected to increase throughout the population, but especially among younger adults, given the recent American College of Cardiology (ACC) and American Heart Association (AHA) update to the definition of hypertension to 130/80mm Hg. The ACC/AHA anticipate that the new definition will result in a tripling of prevalence of hypertension in men under 45 and a doubling among women under 45. Therefore, risk factors among young adults are critical to assess. Diet, obesity, and physical activity are known risk factors, and a growing body of evidence suggests that exposures to air pollution are also associated with risk. However, to date, no study has been able to examine the role of multiple environmental exposures throughout childhood on risk of subsequent hypertension in adulthood, nor how environmental exposures interact with features of the built and social environments to influence risk. The objectives of our study are (1) to determine how features of the total environment experienced during childhood are associated with incident hypertension during adulthood; (2) to examine effect modification of the associations of features of the total environment experienced during childhood with incident hypertension; and (3) to explore how known risk factors of hypertension mediate the associations of the total environment on risk of incident hypertension. We will use the unique resources of the Growing Up Today Study (GUTS) to meet these objectives. GUTS is a prospective cohort study of children whose mothers are participants in the ongoing Nurses’ Health Study II who were first enrolled when they were 9-15 years of age and are currently 22-38 years of age. We will append information on multiple chemical stressors (particulate matter (PM2.5, PM10, PM2.5-10), NO2, ozone), physical stressors (temperature, humidity, noise, light at night, ultraviolet radiation), features of the built and natural environments (proximity to roadways, greenness, blue space, walkability, population density) to the residential addresses of each participant throughout childhood. We will combine the environmental factors with time-varying data collected on social factors (demographics, family socioeconomic status, family make-up and interactions, relationships, team/club participation, experiences with violence/abuse), mental health scales/symptoms, activities/behaviors (e.g. diet and physical activity), and inherent characteristics (e.g. age, sex/gender, race, age at pubertal development). We expect our findings to provide valuable information on the role of childhood exposures on subsequent disease in adulthood, as well as how exposures to multiple factors interact or mediate these exposures, providing valuable information for individual and population level prevention, future risk assessments, and policy decisions.

项目摘要 自2003年以来，以前估计有三分之一的美国成年人患有高血压 作为140/90mm Hg的血压。预计在整个人口中这种流行率将会增加，但 鉴于最近的美国心脏病学院（ACC）和美国心脏，特别是在年轻人中 关联（AHA）对130/80mm HG的高血压定义的更新。 ACC/AHA预计 新的定义将导致45岁以下男性高血压患病率的三倍，女性增加一倍 因此，低于45。因此，年轻人的危险因素对于评估至关重要。饮食，肥胖和体育锻炼 是已知的危险因素，越来越多的证据表明，对空气污染的暴露也是 与风险相关。但是，迄今为止，还没有研究能够检查多个环境的作用 整个儿童期暴露于成年后随后的高血压的风险，或者环境如何 暴露与建筑环境和社会环境的特征相互作用，以影响风险。我们研究的目标 （1）确定儿童期间经历的总环境的特征与 成年期间高血压； （2）检查效果修改特征的关联 儿童时期经历的总环境，发生高血压； （3）探索已知的风险 高血压因素介导了总环境与入射高血压风险的关联。我们 将利用当今成长的研究（肠道）的独特资源来实现这些目标。胆量是一个 母亲是正在进行的护士健康研究II的孩子的前瞻性队列研究 我们将在9-15岁的时候附加，目前22-38岁。 有关多种化学应力源（颗粒物（PM2.5，PM10，PM2.5-10），NO2，臭氧）的信息 压力源（温度，湿度，噪音，夜间光线，紫外线辐射），内置和自然的特征 环境（靠近道路，绿色，蓝色空间，步行，人口密度） 整个童年参与的每个参与的地址。我们将结合环境因素与时变 收集有关社会因素（人口统计学，家庭社会经济地位，家庭构成和互动的数据）， 人际关系，团队/俱乐部参与，暴力/虐待经验），心理健康量表/症状， 活动/行为（例如饮食和体育锻炼）和继承特征（例如年龄，性别/性别，种族，年龄 在青春期开发）。我们希望我们的发现提供有关童年作用的宝贵信息 对成年后随后疾病的暴露以及多种因素的暴露如何相互作用或调解 这些暴露，为个人和人口级别的预防提供价值信息，未来的风险 评估和政策决策。