Computational Modeling Applications in Cardiopulmonary Dynamics

心肺动力学中的计算建模应用

基本信息

批准号：
7251792
负责人：
TARYNN Madysyn WITTEN
金额：
$ 21.68万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7251792
关键词：
3-Dimensional Academy Acer Acquaintances Actins Acute Acute Lung Injury Address Adhesions Adverse effects Advertising Aerosols Affect Age Aging-Related Process Agonist Air Algorithms American Amino Acids Anesthesia procedures Animal Model Animals Antidepressive Agents Apple Applications Grants Architecture Archives Area Arteries Artificial Intelligence Artificial Organs Arts Asthma Authorization documentation Award Back Behavior Behavior monitoring Behavioral Berlin Binding Biochemical Reaction Biochemistry Biography Bioinformatics Biological Biological Assay Biological Models Biological Neural Networks Biological Process Biological Sciences Biology Biomedical Computing Biomedical Engineering Biomedical Research Biophysics Biotechnology Bioterrorism Birefringence Blood Blood Pressure Blood Vessels Blood capillaries Books Boston Boxing Breathing Calcium Calculi California Carbon Monoxide Cardiac Cardiology Cardiopulmonary Cardiopulmonary Physiology Cardiovascular Models Cardiovascular system Case Study Categories Cell Aging Cell Nucleus Cell Proliferation Cell model Cell physiology Cell surface Cells Cereals Characteristics Charge Chemical Models Chemicals Chemistry Chicago Class Clinic Clinical Clinical Data Clinical Drug Development Clinical Pharmacology Clinical Research Coffee Collaborations Collection Communities Comparative Study Complement Complex Computational Biology Computer Simulation Computer software Computers Computing Methodologies Condition Congestive Heart Failure Congresses Consultations Contracts Copyright Cornea Corticotropin-Releasing Hormone Receptors Country Coupled Coupling Critical Care DNA Daily Data Data Analyses Data Set Databases Decision Making Deoxygenated Sickle Hemoglobin Dependence Deposition Depth Development Device or Instrument Development Devices Diagnosis Diffuse Diffusion Directories Disadvantaged Discipline Disease Disease regression Disseminated Intravascular Coagulation Distance Education Doctor of Philosophy Dose Drug Delivery Systems Drug Design Drug Kinetics EGF gene Early Diagnosis Ecology Education Educational Curriculum Educational process of instructing Educational workshop Egypt Electronics Elements Emergency Medicine Endothelial Cells Engineering Ensure Entropy Environment Environmental Exposure Equation Equilibrium Equipment Erythrocytes Ethanol Etiology Evaluation Event Exercise Exhibits Face Facility Construction Funding Category Faculty Failure Feedback Finite Element Analysis Florida Fluorescence Foundations France Frequencies Funding Funding Opportunities Future Gases Gel Gene Expression Regulation Generations Genomics Germany Glutamic Acid Goals Grant Growth Half-Life Hand Head Health Hearing Heart Heart Rate Heating Hemoglobin Hemorrhagic Shock High Performance Computing Homeostasis Hospitals Hot Spot Hour Housing Human Humor Hybrids Hydrogels Imagery In Vitro Individual Inflammatory Institutes Instruction Integrative Medicine Internal Medicine International Internet Interview Intranet Invasive Ion Channel Irritants Isometric Exercise Isotonic Exercise Isotropy Italy Joints Journals Kinetics Knowledge Laboratories Laboratory Research Laws Lead Leadership Learning Left Length Life Ligands Light Link Liposomes Liquid substance Literature Localized Location Logistics Lung Lung Neoplasms Machine Learning Manuals Manuscripts Maps Mathematical Biology Measurement Measures Mechanics Mediator of activation protein Medical Medical Education Medicine Meiosis Membrane Mentors Metabolic Metabolism Methodology Methods Microcirculation Microfluidics Mission Mitosis Modeling Molecular Molecular Conformation Molecular Structure Molecular Weight Monitor Mono-S Morphology Motivation Movement Multimedia Muscle NMDA receptor antagonist Names National Institute of Diabetes and Digestive and Kidney Diseases Nature Nervous system structure Network-based Nicotine None or Not Applicable Nonlinear Dynamics Nuclear Pore Numbers Nurses Online Systems Operative Surgical Procedures Optics Oral Organ Organ failure Organism Outcome Output Paper Parasites Participant Pathologic Pathway Analysis Pathway interactions Patient Care Patients Pattern Peptide Synthesis Performance Peripheral Personal Satisfaction Persons Pharmaceutical Preparations Pharmacodynamics Pharmacy (field)Pharmacy Schools Physical Chemistry Physical activity Physicians Physics Physiological Physiology Plasma Polymers Population Population Dynamics Pre-Post Tests Preparation Pressoreceptors Principal Investigator Prize Probability Problem Solving Procedures Process Production Property Prosthesis Design Protein Binding Proteins Protocols documentation Psychological Techniques Public Domains Public Health Publications Published Comment Published Directory Publishing Pump Purpose Qualifying Quantitative Structure-Activity Relationship Rabies Range Rate Reaction Readiness Reading Recipe Records Regulator Genes Research Research Personnel Residual state Resolution Resources Respiration Respiratory System Respiratory Therapy Risk Assessment Role Route Running Safety Sampling Scanning Schedule Scheme Schools Science Scientist Sclera Scopolamine Secure Sepsis Series Services Shock Sickle Cell Anemia Sickle Hemoglobin Side Signal Transduction Signaling Molecule Simulate Sinus Site Sleep Sleep Stages Slide Smooth Muscle Societies Software Tools Solid Solutions Source Space Models Specific qualifier value Standards of Weights and Measures Statistical Mechanics Stochastic Processes Stream Stress Stroke Volume Structure Structure of parenchyma of lung Students Suggestion Sum Supercomputing Surface Surveys System Systems Analysis Systems Biology Tactile Techniques Technology Telemedicine Temperature Terminology Testing Texas Textbooks Therapeutic Therapeutic Agents Thermodynamics Time Tissue Model Tissues Today Tokyo Tracheobronchial Training Transport Process Trauma Travel Tumor Necrosis Factor-alpha United States United States National Institutes of Health Universities Update Urine Validation Valine Variant Vascular Diseases Vascular Endothelial Growth Factors Vascular Graft Ventricular Ventricular Premature Complexes Video Recording Videoconferences Videoconferencing Virginia Water Week Women&apos s Health Work Workplace Wound Healing absorption abstracting antimicrobial asthmatic airway base capillary cardiopulmonary system clinically relevant cluster computing collaboratory college computer science computerized data processing computerized tools concept continuing medical education cost cytotoxicity data collection evaluation day density design desire disability dosimetry drug development drug discovery drug synthesis experience extracellular falls follow-up graduate medical education human TNF protein human disease improved in vivo innovation insight interest laboratory facility lecturer lectures light scattering mathematical model medical schools medical specialties member millimeter models and simulation molecular dynamics monocyte monomer multi-scale modeling nanometer nanoscale nanosystems nephelometry network models novel novel strategies particle pharmacodynamic model pharmacokinetic model phosphoric diester hydrolase photonics planetary Atmosphere pollutant polymerization pre-clinical pressure professor programs protein metabolite quantum real world application receptor relating to nervous system repository research and development research study residence respiratory response sex simulation size skills small molecule spatial temporal variation symposium tactile display temperature jump theories therapeutic target tissue/cell culture tool transmission process trend tumorigenic vector vibration ward wasting

项目摘要

DESCRIPTION (provided by applicant): The Virginia Commonwealth University (VCU) short course on Computational Modeling Applications in Cardiopulmonary Dynamics will introduce clinician scientists to the application of appropriate theoretical and computational models to Cardiopulmonary physiology ranging from cellular and biomolecular scale topics to mechanical biophysics and fluid dynamics. Course registrants (n=30) will attend modeling concept lectures in the morning and break out into smaller groups of 10-15 for afternoon hands-on instruction and tutorials on specialized topics. Evening sessions will highlight successful integration of computational modeling into Cardiopulmonary research to illustrate possibilities and practical considerations. One evening will address preparing grants in response to NHLBI funding opportunities that involve computational modeling, and another will provide instruction in the Responsible Conduct of Research. VCU faculty are drawn from the Center for the Study of Biological Complexity (CSBC), School of Engineering (biomedical, mechanical, chemical & life sciences, computer science), School of Medicine (emergency medicine, internal medicine), and School of Pharmacy (pharmaceutics). The course will last 7 days (recognizing time constraints due to patient care obligations), and attendees will only be expected to arrive with college-level background in calculus and physics. An online pre-test will assess level of understanding and help course faculty refine their lectures. Continuing medical education and graduate course credit will be awarded. The course will be offered twice a year, with one session held in conjunction with the Annual Systems Biology Summit, also sponsored by CSBC. CSBC will administer all aspects of the course. The Center offers degree programs in Bioinformatics and Integrated Life Sciences and a Bioinformatics and Bioengineering Summer Institute. VCU will offer intensive modeling mentoring in Richmond and create a database of computational modeling expertise throughout the US that will allow all course participants to identify local mentors who can reinforce the training received. All course materials and presentations (synchronized audio-Powerpoint presentations) will be made available for Web-based and DVD dissemination at the conclusion of the course. Web streaming, Internet broadcasting, and pod-casting methods will be used where appropriate. Course participants will complete pre- and post-tests as well as Likert scale and subjective evaluations for each presentation, the course overall, and site logistics and customer service. CSBC will track participants to determine whether they seek follow-on tutorial assistance (from VCU or directory resource), apply computational modeling approaches to current or new projects; publish abstracts and/or papers that incorporate computational modeling; prepare, submit, and/or receive funding for grant proposals that incorporate computational modeling; and attend additional workshops or conferences on modeling.

描述（由申请人提供）：弗吉尼亚联邦大学 (VCU) 心肺动力学计算建模应用短期课程将向临床科学家介绍适当的理论和计算模型在心肺生理学中的应用，范围从细胞和生物分子尺度主题到机械生物物理学和流体动力学。课程注册者 (n=30) 将在上午参加建模概念讲座，并分成 10-15 人的小组进行下午的实践指导和专业主题教程。晚上的会议将重点介绍计算模型与心肺研究的成功整合，以说明可能性和实际考虑因素。一个晚上将讨论如何准备拨款，以应对涉及计算建模的 NHLBI 资助机会，另一个晚上将提供负责任的研究行为方面的指导。弗吉尼亚联邦大学的教师来自生物复杂性研究中心 (CSBC)、工程学院（生物医学、机械、化学与生命科学、计算机科学）、医学院（急诊医学、内科）和药学院（药剂学）。该课程将持续 7 天（考虑到由于患者护理义务而造成的时间限制），参加者只需具备大学水平的微积分和物理学背景。在线预测试将评估理解水平并帮助课程教师完善他们的讲座。将授予继续医学教育和研究生课程学分。该课程每年提供两次，其中一次与年度系统生物学峰会同时举行，该峰会也由 CSBC 赞助。 CSBC 将管理课程的各个方面。该中心提供生物信息学和综合生命科学学位课程以及生物信息学和生物工程暑期学院。弗吉尼亚联邦大学将在里士满提供密集的建模指导，并在整个美国创建一个计算建模专业知识数据库，使所有课程参与者能够找到可以加强所接受培训的当地导师。所有课程材料和演示文稿（同步音频-Powerpoint 演示文稿）将在课程结束时通过网络和 DVD 传播。将在适当的情况下使用网络流媒体、互联网广播和播客方法。课程参与者将完成事前和事后测试以及李克特量表和对每次演示、课程整体以及现场物流和客户服务的主观评估。 CSBC 将跟踪参与者，以确定他们是否寻求后续教程帮助（来自 VCU 或目录资源）、将计算建模方法应用于当前或新项目；发表包含计算建模的摘要和/或论文；为包含计算模型的拨款提案准备、提交和/或接收资金；并参加其他有关建模的研讨会或会议。