Enhanced Surveillance for Newly Preventable Diseases (ARI and AGE Surveillance) - Rochester, NY

加强对新可预防疾病的监测（ARI 和 AGE 监测）- 纽约州罗彻斯特

• 批准号: 9762621
• 负责人: Geoffrey Alan Weinberg
• 金额: $ 100万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762621
• 关键词: Enhanced; Surveillance; Newly; Preventable; Diseases

ABSTRACT This proposal is to enhance the New Vaccine Surveillance Network (NVSN) site in Rochester, NY, which has for 10 years been focused on prospective, population-based surveillance for acute gastroenteritis (AGE) caused by rotavirus, norovirus, and other viral pathogens, and for the past year, population-based surveillance for acute respiratory infections. We propose to continue and extend surveillance for ARI with a focus on influenza, respiratory syncytial virus (RSV), enterovirus-D68 (EV-D68), and other vaccine- preventable or potentially vaccine-preventable viruses, in order to both measure influenza vaccine effectiveness (VE) in preventing laboratory-confirmed influenza infections among hospitalized children <18 years of age, and to assess the inpatient burden of viral pathogens associated with ARIs, particularly influenza, RSV and EV-D68. We also will continue the AGE surveillance to allow for similar determinations of AGE burden and rotavirus vaccine efficacy among children hospitalized or visiting the emergency departments. The over-arching goal of the NVSN is to inform the nation about the burden of vaccine-preventable diseases (VPDs), and the impact of new vaccines and vaccine policies. Our Rochester NVSN site (a founding NVSN member), has been a leader in shaping all aspects of the NVSN, including population-based surveillance for new or upcoming vaccines, vaccine effectiveness (VE) studies, refinement of diagnostic laboratory methods, health services and epidemiologic studies, and dissemination of findings. We have the infrastructure and comprehensive expertise to begin all activities on day 1 of the funding period. Our NVSN site has: experienced personnel who have led and published many past NVSN influenza VE, surveillance, and molecular diagnostic laboratory studies; accurate laboratory and surveillance techniques consistent with CDC procedures; and outstanding epidemiologic and health services research capabilities. We have full access to all hospital and ED databases to complement surveillance activities. Our catchment area, the Monroe County NY/Rochester Metropolitan Statistical Area, has a total population of >1,000,000; >95% of ARI admissions for Monroe County resident children <18 years of age occur at our two NVSN hospitals, with nearly 1,000 hospitalizations for ARIs per year. Thus, we have a “captured population” precisely suited for the NVSN population-based surveillance projects. This proposal will provide critical information to develop sound polices consistent with national goals to preventing VPD in children.

抽象的 该提议是为了增强纽约州罗切斯特的新疫苗监视网络（NVSN）地点 已有10年的重点是针对急性胃炎的预期，基于人群的监视（年龄） 由轮状病毒，诺如病毒和其他病毒病原体引起，在过去的一年中 急性呼吸道感染的监测。我们建议继续对ARI进行监视 专注于影响，呼吸综合病毒（RSV），肠病毒-D68（EV-D68）和其他疫苗 可预防或潜在的可预防疫苗的病毒，以便两者都测量影响力疫苗 有效性（VE）防止住院儿童的实验室确认的影响<18 年龄，并评估与ARIS相关的病毒病原体的住院伯嫩，特别是 影响力，RSV和EV-D68。我们还将继续年龄监视，以允许类似的确定 年龄伯恩和轮状病毒疫苗效率的儿童住院或访问紧急情况 部门。 NVSN的整理目标是通知国家燃烧疫苗可预防的燃烧 疾病（VPD）以及新疫苗和疫苗政策的影响。我们的Rochester NVSN网站（创业） NVSN成员），一直是塑造NVSN的各个方面的领导者，包括基于人群的 新疫苗或即将进行的疫苗的监视，疫苗有效性（VE）研究，诊断的细化 实验室方法，卫生服务和流行病学研究以及发现的传播。我们有 基础设施和全面的专业知识，开始在资金期的第1天开始所有活动。 我们的NVSN网站有：经验丰富的人员，他们领导并出版了许多过去的NVSN影响力， 监视和分子诊断实验室研究；准确的实验室和监视技术 与CDC程序一致；以及杰出的流行病学和卫生服务研究能力。 我们可以完全访问所有医院和ED数据库，以补充监视活动。我们的集水区 纽约州门罗县/罗切斯特大都会统计区域，总人口> 1,000,000； 在我们的两个NVSN中，>门罗县居民儿童的ARI入院率> 95％ 医院，每年的ARIS近1,000次住院。那我们有一个“被捕的人口” 精确地适合基于NVSN的基于人群的监视项目。该建议将提供关键 信息以培养警察的信息与国家目标相一致，以防止儿童VPD。