IP21-002, Enhanced Surveillance Network for Enteric and Respiratory Viruses in Children: Assessing Disease Burden, Natural History, and Vaccine Effectiveness

IP21-002，儿童肠道和呼吸道病毒的增强监测网络：评估疾病负担、自然史和疫苗有效性

• 批准号: 10674572
• 负责人: Geoffrey Alan Weinberg
• 金额: $ 275万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674572
• 关键词: IP21; 002; Enhanced; Surveillance; Network

PROJECT SUMMARY/ABSTRACT (COMPONENTS A, B and C): Viral acute respiratory infections (ARI) and acute gastroenteritis (AGE) remain major causes of morbidity in children, making vaccine development and implementation a high public health priority. The overall goal of the CDC New Vaccine Surveillance Network (NVSN) is to establish a network of US institutions that develop and implement standard research protocols to answer important questions about the burden of disease and natural history of vaccine preventable diseases, specifically, those causing ARI and AGE. A second goal of population-based NVSN surveillance is to provide accurate estimates of vaccine effectiveness (VE) in preventing pediatric hospitalization or medical care visits. A third goal is the ability to rapidly pivot to study novel agents such as enterovirus-D68 (EV-D68) or SARS-CoV-2, and syndromes such as acute flaccid myelitis (AFM) and multisystem inflammatory syndrome in children (MIS-C). The proposed work (comprising Mandatory Core A, and Optional Components B and C) will enhance the NVSN site in Rochester, NY—one of 2 original members of the now 7-site network. For 20 years we have published important studies on the burden of disease and natural history of AGE due to rotavirus and norovirus, and ARI due to influenza, (RSV), and other viruses. These data helped inform AAP and ACIP on pediatric influenza and rotavirus vaccination, and palivizumab use for RSV prevention. Our specific aims are:  Mandatory Core Component A: Perform prospective, population-based active surveillance for ARIs and AGEs in inpatient and ED settings as well as asymptomatic controls, for children 0-18 years. We will use molecular diagnostics for rotavirus, norovirus, influenza, RSV, PIV, EV-D68, SARS-CoV-2, and other viruses. We will assess VE for influenza, rotavirus, and future SARS-CoV-2 vaccines in preventing pediatric hospitalizations and ED visits. We will delineate the disease burden of ARI and AGE using our unique capture of virtually all pediatric hospitalizations and ED visits in our region. We will assess the impact of future vaccines and other immunoprophylaxis strategies. We will perform active surveillance and epidemiologic studies of acute flaccid myelitis (AFM) syndrome in children. Finally, we will perform and lead epidemiological, implementation and laboratory studies based on population-based NVSN surveillance.  Optional Component B: Implement active prospective population-based ARI/AGE surveillance studies in children seeking medical care in outpatient practices, as the burden of ARI and AGE are likely high.  Optional Component C: Investigate the incidence, spectrum of disease, and risk factors associated with SARS-CoV-2 MIS-C. Our proposed research will provide high impact information to develop sound policies for the prevention of pediatric vaccine-preventable diseases, and to improve the health of US children.

项目摘要/摘要（组件A，B和C）： 病毒急性呼吸道感染（ARI）和急性胃肠炎（年龄）仍然是发病率的主要原因 在儿童中，使疫苗开发和实施成为高公共健康优先事项。总体目标 CDC新疫苗监视网络（NVSN）是建立一个发展的美国机构网络 并实施标准研究方案，以回答有关疾病燃烧和的重要问题 疫苗可预防疾病的自然病史，特别是引起ARI和年龄的疫苗。第二个目标 基于人群的NVSN监视是为了提供对疫苗有效性（VE）的准确估计。 防止小儿住院或医疗访问。第三个目标是能够快速旋转研究的能力 新型药物，例如肠病毒-D68（EV-D68）或SARS-COV-2，以及急性易变的综合征 儿童（MIS-C）的脊髓炎（AFM）和多系统炎症综合征。 拟议的工作（包括强制性核心A和可选组件B和C）将增强 纽约州罗切斯特的NVSN站点 - 现在7个站点网络的2个原始成员之一。我们有20年 关于轮状病毒和疾病伯恩的伯恩伯恩和自然历史的重要研究 诺如病毒和ARI由于影响力，（RSV）和其他病毒。这些数据帮助AAP和ACIP通知 小儿影响和轮状病毒疫苗接种，以及用于预防RSV的Palivizumab。我们的具体目的是： 强制性核心部分A：对ARIS和 0-18岁儿童的住院和ED设置以及不对称控制的年龄。我们将使用 轮状病毒，诺如病毒，影响力，RSV，PIV，EV-D68，SARS-COV-2和其他病毒的分子诊断。 我们将评估VE VE的影响力，轮状病毒和未来的SARS-COV-2疫苗，以防止小儿 住院和急诊就诊。我们将使用我们独特的 在我们地区捕获几乎所有儿科住院和ED访问。我们将评估 未来的疫苗和其他免疫预防策略。我们将执行主动监视和 儿童急性松弛脊髓炎（AFM）综合征的流行病学研究。最后，我们将表演和领导 基于基于人群的NVSN监视的流行病学，实施和实验室研究。 可选组件B：在 由于ARI和年龄的燃烧可能很高，因此在门诊习惯中寻求医疗服务的儿童。 可选成分C：调查事件，疾病范围以及与之相关的风险因素 SARS-COV-2 MIS-C。 我们拟议的研究将提供高影响信息，以制定预防的合理政策 儿科疫苗可预防的疾病，并改善美国儿童的健康状况。

项目成果

Seasonality, clinical characteristics, and outcomes of respiratory syncytial virus disease by subtype among children less than five years old, New Vaccine Surveillance Network, United States, 2016-2020.

五岁以下儿童呼吸道合胞病毒病按亚型的季节性、临床特征和结果，新疫苗监测网络，美国，2016-2020 年。

• DOI: 10.1093/cid/ciae085
• 发表时间: 2024
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Toepfer,ArianaP;Amarin,JustinZ;Spieker,AndrewJ;Stewart,LauraS;Staat,MaryAllen;Schlaudecker,ElizabethP;Weinberg,GeoffreyA;Szilagyi,PeterG;Englund,JanetA;Klein,EileenJ;Michaels,MarianG;Williams,JohnV;Selvarangan,Rangaraj
• 通讯作者: Selvarangan,Rangaraj