Low-cost Mobile Oral Cancer Screening for Low Resource Setting

资源匮乏的低成本移动口腔癌筛查

基本信息

批准号：
9762395
负责人：
Rongguang Liang
金额：
$ 92.26万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-19 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762395
关键词：
Accounting Acute Address Adherence Algorithms Cancer Center Car Phone Cellular Phone Chronic Clinical Collaborations Computer software Dental Detection Device Designs Devices Diagnosis Diagnostic Disease Progression Early Diagnosis Engineering Evidence based intervention FDA approved Feedback Goals Health Health Care Costs Health Expenditures Health Personnel Healthcare Human papilloma virus infection Image Imaging Device Incidence India Individual Instruction International Lesion Light Malignant - descriptor Malignant Neoplasms Modality Morbidity - disease rate Oral Oral Diagnosis Oral health Oropharyngeal Squamous Cell Carcinoma Participant Patient risk Patients Performance Phase Population Populations at Risk Premalignant Prevention Prevention strategy Quality of life Research Infrastructure Resolution Resources Roswell Park Cancer Institute Rural Science Screening for Oral Cancer Site South Asian Southeastern Asia Specialist Stage at Diagnosis Survival Rate System Time Treatment outcome Triage Work alpha-SNAP base cancer prevention community setting cost diagnostic accuracy follow-up health care availability health literacy high risk image processing imaging modality imaging platform imaging probe imaging system improved low and middle-income countries malignant mouth neoplasm medical specialties mobile application mortality multidisciplinary multimodality novel oncology oral lesion portability prototype public health relevance recruit rural area screening southeast Asian tool treatment strategy trend validation studies young adult

项目摘要

DESCRIPTION (provided by applicant): Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, accounting for approximately 400,000 new cancer cases each year. About two-thirds of these cancers occur in low- and middle-income countries (LMICs), with very high rates in South and South-East Asian. While the 5-year survival rate in the U.S. for OSCC is 62%, the survival rate is only 10-40% and the cure rate around 30% in the developing world. Low survival rate is primarily attributed to the delay in diagnosis and the resultant progression of disease to an advanced stage at diagnosis. This problem is more acute in LMICs where least amount of resources is available for health care expenditure. Diagnosis is often delayed in marginalized at-risk populations living in rural areas with poor access to specialty health care, low health literacy, and problematic adherence to follow up. Early diagnosis offers the best chance to improved treatment outcomes and survival for an individual diagnosed with OSCC. Diagnosis of early oral lesions requires effective screening of the population. It is also important to detect and diagnose the chronic and malignant oral lesions, so efficient prevention and treatment strategies can be devised. We propose a mobile intra-oral imaging device and image platform to address the urgent need of a low-cost, portable, easy to use, and reliable imaging device for oral cancer screening in low resource settings. To achieve this goal, we have formed an international, multidisciplinary team with complementary expertise in engineering, oncology, and manufacturing/distribution. We have one of the largest cancer centers (Mazumdar- Shaw Cancer Center (MSCC), India) in LMIC to demonstrate the functionalities and validate clinical performance of the proposed device for oral cancer screening in low resource settings. We also have a collaboration with one of the largest dental companies (Carestream Health Inc) in the world to fabricate and distribute the products. We will develop prototypes in the UH2 Phase and demonstrate the functionalities and suitability in low resource setting at Roswell Park Cancer Institute and MSCC. In the UH3 Phase, we will refine the mobile intra-oral imaging device, and validate the clinical usefulness in four rural districts in Bangalore. This project is significant because early diagnosis of oral lesins and timely patient referral to specialists can reduce disease progression, reduce morbidity and mortality, and cut healthcare costs. We expect that use of this mobile based dual-modality screening approach for early diagnosis of oral cancers in community settings will eventually improve detection rates, treatment outcomes, and quality of life of patients.

描述（由申请人提供）：口腔和口咽鳞状细胞癌 (OSCC) 并列为全球第六大常见癌症，每年新增约 400,000 例癌症病例，其中约三分之二发生在低度和中度癌症中。收入国家 (LMIC)，南亚和东南亚的发病率非常高，而美国 OSCC 的 5 年生存率为 62%。发展中国家的治愈率仅为 10-40%，治愈率约为 30%，低生存率主要是由于诊断延迟以及由此导致的疾病进展到诊断时的晚期，这一问题在中低收入国家更为严重。对于生活在农村地区的贫困高危人群来说，可用于医疗保健支出的资源最少，因为他们很难获得专业医疗保健，健康素养较低，并且早期诊断的依从性存在问题。有机会改善治疗结果和生存诊断患有口腔鳞状细胞癌的个体需要对人群进行有效的筛查，检测和诊断慢性和恶性口腔病变也很重要，因此我们可以设计出有效的预防和治疗策略。成像设备和图像平台，以满足在资源匮乏的情况下对低成本、便携式、易于使用和可靠的口腔癌筛查成像设备的迫切需求。为了实现这一目标，我们组建了一支具有互补性的国际化、多学科团队。工程、肿瘤学等方面的专业知识我们拥有 LMIC 最大的癌症中心之一（印度 Mazumdar-Shaw 癌症中心 (MSCC)），用于在资源匮乏的环境中展示所提议的口腔癌筛查设备的功能并验证其临床性能。我们将与世界上最大的牙科公司之一（Carestream Health Inc）合作制造和分销产品，我们将在 UH2 阶段开发原型，并在罗斯威尔帕克癌症研究所和 MSCC 的低资源环境中展示其功能和适用性。在UH3阶段，我们将完善移动口腔内成像设备，并验证其临床实用性该项目意义重大，因为口腔菌素的早期诊断和及时将患者转诊给专家可以减少疾病进展，降低发病率和死亡率，并降低医疗费用。在社区环境中早期诊断口腔癌最终将提高检出率、治疗结果和患者的生活质量。