3D printing glass micro-objectives for ultrathin endoscope

3D打印超薄内窥镜玻璃显微物镜

• 批准号: 10377856
• 负责人: Rongguang Liang
• 金额: $ 20.33万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10377856
• 关键词: 3-Dimensional; 3D Print; Address; Adoption; Brain imaging; Chemicals; Clinical; Complex; Development; Dimensions; Elements; Endoscopes; Environment; Evaluation; Glass; Goals; Hardness; Image; Imaging Techniques; Imaging technology; Industry Standard; Light; Liquid substance; Metals; Methods; Molds; Optics; Organ; Performance; Photosensitivity; Plant Resins; Polishes; Polymers; Printing; Process; Property; Refractive Indices; Research; Resistance; Resolution; Silicon Dioxide; Solvents; Speed; Surface; System; Techniques; Technology; Translating; cancer imaging; clinical application; confocal imaging; cost; covalent bond; design; fluorescence imaging; high resolution imaging; imaging system; improved; lens; life time cost; multiphoton imaging; novel; optical imaging; polymerization; process optimization; prototype; transmission process; two-photon

Abstract We propose to develop 3D printing technology of glass micro-objective and micro optics for ultrathin endoscope to address the increasing demand in developing compact endoscopes in cancer imaging. The primary challenge in developing micro-objective is the fabrication, traditional fabrication methods don’t have sufficient capabilities in fabricating micro optics. GRIN lens is the only commercially available micro-objective, but it has a number of limitations, such as narrow working spectrum and very short working distance. 3D printing process has been developed recently to print polymer micro-objective with two-photon polymerization (TPP) process. However, there are some inherent limitations in printed polymer optics, including short lifetime due to the yellowish, low transmission in UV and NIR spectrum, and limitations in hardness, thermal resistance, and chemical resistance. Glass optics is preferred for clinical application because of its excellent optical, chemical, and thermal properties. To meet the increasing needs of high-precision glass micro-optics for endoscope and address the major limitations of current 3D printing optics, we have developed a solvent-free, pre-condensed liquid silica resin (LSR) and two-photon 3D printing process for glass optics. 3D printing of glass micro-optics with isotropic shrinkage, micrometer resolution, low deviation peak-to-valley value (<100 nm), and low surface roughness (< 6 nm) has been achieved. The solvent-free, UV curable LSR with a majority of the already formed covalent bonds (Si-O-Si) is novel that it significantly reduces the material shrinkage, increases the printing speed, and simplifies the process to obtain inorganic silica. The printed glass micro optics has better imaging performance with higher resolution, wider working spectrum, better transmission from UV to NIR, and longer lifetime. The 3D printing process for micro glass objective is novel in that it can fabricate more complex optical systems and is particularly suitable for rapid prototyping at low-cost. The goal of this project is to develop 3D printed glass micro-objective and micro optics for ultra-compact endoscope. We will first optimize pre-condensed LSR (Aim 1), and then print micro-objectives and evaluate the performance (Aim 2). This project is significant in that it will establish a new 3D printing technology for fabricating the much-needed glass micro-objective and micro-optics for endoscope in cancer imaging. The rapid prototyping capability at low cost will accelerate the rapid transition of the advanced imaging technologies from the lab to clinical applications.

抽象的 我们建议开发超薄内窥镜的3D打印技术和微观光学器件的3D打印技术 解决癌症成像中紧凑型内窥镜的需求不断增长。主要挑战 在开发微观目标方面是制造，传统制造方法没有足够的功能 在制造微光学器件中。 Grin Lens是唯一可商购的微观目标，但有很多 局限性，例如狭窄的工作频谱和非常短的工作距离。 3D打印过程已经 最近开发用于用两光子聚合（TPP）过程打印聚合物微观目标。然而， 印刷聚合物光学元件有一些继承的局限性，包括由于淡黄色，低寿命 紫外线和NIR光谱的传播，以及硬度，热阻力和耐化学性的限制。 由于其出色的光学，化学和热性能，因此首选用于临床应用的玻璃光学元件。 为了满足高精度玻璃微启示对内窥镜的不断增长的需求，并解决了专业 当前3D打印光学元件的局限性，我们开发了一个不溶液的预粘液液二氧化硅树脂（LSR） 以及玻璃光学元件的两光子3D打印过程。与各向同性收缩的3D玻璃微镜印刷， 千分尺分辨率，低出发峰值到valley值（<100 nm），低表面粗糙度（<6 nm）具有 实现了。无溶液，紫外线可固化的LSR，其大部分已经形成的共价键 （Si-O-SI）是新颖的，它大大降低了材料的收缩，提高印刷速度并简化 获得无机二氧化硅的过程。印刷玻璃微光学元件具有更好的成像性能 较高的分辨率，较宽的工作频谱，从紫外线到NIR的更好传播以及更长的寿命。 3D 微玻璃目标的打印过程是新颖的，因为它可以制造更复杂的光学系统和 特别适合在低成本下快速进行原型制作。 该项目的目的是开发3D打印的玻璃微观目标和微观光学元件 内窥镜。我们将首先优化预启用的LSR（AIM 1），然后打印微观目标并评估 性能（目标2）。 该项目很重要，因为它将建立一种新的3D打印技术，用于制造急需的 用于癌症成像中内窥镜的玻璃微观和微观镜。低点的快速原型制作能力 成本将加速高级成像技术从实验室到临床应用的快速过渡。