Fourier Ptychographic Endoscopy

傅里叶叠层内窥镜检查

基本信息

批准号：
9247780
负责人：
Rongguang Liang
金额：
$ 18.35万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2019-01-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): To address the inherent trade-offs between the size, resolution, and field of view (FOV) of thin clinical endoscopes, we propose a novel ptychographic endoscope based on the Fourier ptychography (FP) technology. Ptychographic endoscope uses angularly varying illumination to extend the performance beyond the limit defined by the optical system. It has the following key features: (1) the achievable resolution of ptychographic endoscopy system is determined by the largest incident angle, not the numerical aperture (NA) of the employed miniaturized optics; (2) it is possible to recover the high resolution sample image and correct for remaining aberrations of the employed optics, enabling a much larger design space; (3) the recovered high-resolution images at different depths can be used to construct a 3D image of the tissue topographic structure; and (4) with continuous illumination, the instrument works as a conventional low resolution endoscope. When high resolution imaging is needed, it works in FP mode with sequential pulse illuminations. The goal of this proposal is to develop thin endoscope and image reconstruction algorithms to demonstrate the ptychographic endoscopy system, by pursuing the following aims: (1) develop the ptychographic endoscopy system using miniaturized optics and illumination fibers (Month 1-14); (2) develop a high speed image construction platform to construct a high-resolution image over large FOV and large depth of field in real time (Month 1-15); and (3) characterize and evaluate the imaging performance of the ptychographic endoscopy system (Month 14-24). Ptychographic endoscope is compact and doesn't require a complicated system, it is also low cost because only a ring illumination source is needed. Most important, it addresses inherent trade-offs between the size, resolution, and FOV of thin endoscopes. Successful completion of the proposed ptychographic endoscope will enable us to develop thin endoscopes for unmet clinical needs by enabling clinicians to accurately detect and diagnosis diseases, particularly in regions with limited access.

描述（由申请人提供）：为了解决薄型临床内窥镜的尺寸、分辨率和视场（FOV）之间的固有权衡，我们提出了一种基于傅立叶叠层描记（FP）技术的新型叠层描记内窥镜。改变照明以将性能扩展到光学系统定义的极限之外，它具有以下主要特征：（1）叠层内窥镜系统可实现的分辨率。由最大入射角决定，而不是所采用的小型化光学器件的数值孔径 (NA)；(2) 可以恢复高分辨率样本图像并校正所用光学器件的剩余像差，从而实现更大的设计空间； (3)恢复的不同深度的高分辨率图像可用于构建组织地形结构的3D图像；(4)在连续照明下，该仪器在进行高分辨率成像时充当传统的低分辨率内窥镜。该提案的目标是开发薄型内窥镜和图像重建算法来演示叠层内窥镜系统，其目标如下：（1）开发使用小型化光学器件的叠层内窥镜系统。和照明光纤（1-14月）；（2）开发高速图像构建平台，实时构建大视场和大景深的高分辨率图像（1月） 1-15）；（3）表征和评估叠层内窥镜系统的成像性能（第14-24个月），叠层内窥镜结构紧凑，不需要复杂的系统，而且由于只有环形照明，因此成本也较低。最重要的是，它解决了薄型内窥镜的尺寸、分辨率和视场之间的固有权衡问题，成功完成所提出的叠层成像内窥镜将使我们能够开发薄型内窥镜。通过使靴子能够准确地检测和诊断疾病，特别是在交通有限的地区，未满足临床需求。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Motion-corrected Fourier ptychography.

DOI：
10.1364/boe.7.004543
发表时间：
2016-06
期刊：
Biomedical optics express
影响因子：
3.4
作者：
Liheng Bian;G. Zheng;K. Guo;J. Suo;Changhuei Yang;Feng Chen;Qionghai Dai
通讯作者：
Liheng Bian;G. Zheng;K. Guo;J. Suo;Changhuei Yang;Feng Chen;Qionghai Dai

Chromatic confocal microscopy using liquid crystal display panels.

DOI：
10.1364/ao.58.002085
发表时间：
2019-03
期刊：
Applied optics
影响因子：
1.9
作者：
Qi Cui;Rongguang Liang
通讯作者：
Qi Cui;Rongguang Liang

Fiber bundle image restoration using deep learning

DOI：
10.1364/ol.44.001080
发表时间：
2019-03-01
期刊：
OPTICS LETTERS
影响因子：
3.6
作者：
Shao, Jianbo;Zhang, Junchao;Barnard, Kobus
通讯作者：
Barnard, Kobus

Angular light modulator using optical blinds.

使用光学百叶窗的角度光调制器。

DOI：
10.1364/oe.24.028467
发表时间：
2016
期刊：
Optics express
影响因子：
3.8
作者：
Bian,Zichao;Alhudaithy,Soliman;Wang,Zhe;Zhang,Zibang;Guo,Kaikai;Bian,Liheng;Tomizawa,Yuji;Satonick,Peter;Hoshino,Kazunori;Zheng,Guoan
通讯作者：
Zheng,Guoan

Terapixel hyperspectral whole-slide imaging via slit-array detection and projection