Neurodevelopmental substrates of emotion regulation in obese, binge eating youth

肥胖、暴食青少年情绪调节的神经发育基础

• 批准号: 9492561
• 负责人: Andrea Beth Goldschmidt
• 金额: $ 16.62万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9492561
• 关键词: Adolescence; Adolescent; Age; Amygdaloid structure; Anterior; Behavioral; Binge Eating; Brain imaging; Brain region; Chicago; Child; Childhood; Clinical Investigator; Cognition; Cognitive; Competence; Data; Development; Disease; Dorsal; Early identification; Eating; Eating Behavior; Eating Disorders; Emotional; Emotions; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Health; Impaired health; Impairment; Insula of Reil; International; Intervention; K-Series Research Career Programs; Link; Magnetic Resonance Imaging; Maintenance; Measures; Medical; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Nature; Neurobiology; Neurosciences; Obesity; Outcome; Overweight; Paper; Parents; Participant; Pattern; Pilot Projects; Prefrontal Cortex; Preventive Intervention; Preventive treatment; Process; Psychiatry; Psychopathology; Reporting; Research; Research Activity; Research Personnel; Sampling; Scientist; Syndrome; To specify; Training; Training Activity; Training Programs; Translating; Universities; Ventral Striatum; Weight; Weight maintenance regimen; Youth; affective neuroscience; career; career development; cingulate cortex; cognitive control; cognitive reappraisal; design; developmental neurobiology; eating pathology; effective intervention; emotion regulation; experience; innovation; loss of control over eating; negative affect; neural circuit; neuroimaging; novel; obesity development; obesity in children; obesity treatment; physical conditioning; prevent; professor; programs; psychosocial; public health relevance; relating to nervous system; therapy development; virtual

 DESCRIPTION (provided by applicant): Loss of control (LOC) while eating (i.e., the sense that one cannot control what or how much one is eating) is prevalent among children and adolescents. LOC eating is associated with a range of physical and psychosocial health impairments, including obesity and the development of partial- and full-syndrome eating disorders. Early identification is thus critical for preventing or minimizing these adverse health outcomes. However, little is known about the development of LOC eating in children and, consequently, there is a paucity of effective interventions. Impairments in emotion regulation appear to be involved in the onset and maintenance of eating pathology in obese samples. To date, emotion regulation in youth with LOC eating problems is poorly understood, and research on underlying neurodevelopmental substrates is virtually nonexistent. The proposed research aims to characterize neurocircuitry involved in emotion regulation among 30 overweight children with LOC eating as compared to 30 overweight and 15 normal-weight controls without LOC. Participants will complete a cognitive reappraisal task whilst situated in an MRI scanner, the purpose of which is to characterize neural activity involved in reappraisal versus an emotion maintenance control condition. The proposed research aims to advance the field's understanding of the nature and correlates of LOC eating in overweight children so as to inform intervention development. The research also fits within the broader context of the applicant's career development goals. The candidate is an Assistant Professor of Psychiatry and Behavioral Neuroscience whose research program has focused on pediatric eating and weight disorders, particularly binge eating and its relationship with negative affect. The overarching goal of the 4-year training program is to establish the candidate as an independent investigator. Specific training activities will focus on gaining a sufficient understanding of neurocircuitry involved in emotion regulation across childhood and adolescence to be able to utilize a developmental neuroscience framework for the probing of dysregulated eating; and obtaining experience collecting, analyzing, and interpreting fMRI data. The mentorship team consists of internationally-known experts in developmental psychopathology, affective neuroscience, and pediatric eating and weight disorders who will provide conceptual oversight of the training plan and nurture the applicant's career trajectory. Research and training activities will be carried out at the University of Chicago's Department of Psychiatry and Behavioral Neuroscience and Brain Imaging Research Center. This Career Development Award will fill gaps in the candidate's training in order to broaden her expertise in pediatric obesity and eating disorders, ultimately guiding the research program towards the development of novel interventions for these problems, and facilitating her transition into an independent clinical investigator.

 描述（由适用提供）：进食时失去控制（LOC）（即，人们无法控制一个人正在吃什么或正在吃什么）在儿童和青少年中普遍存在。 LOC饮食与一系列身体和社会心理健康障碍有关，包括肥胖和部分局部和全合成饮食障碍的发展。因此，早期识别对于预防或最大程度地减少这些不良健康结果至关重要。但是，对于儿童的LOC饮食发展知之甚少，因此，有效的干预措施很少。情绪调节的障碍似乎参与了肥胖样本中饮食病理学的发作和维持。迄今为止，对LOC饮食问题的年轻人进行的情绪调节知之甚少，并且对基本神经发育底物的研究几乎不存在。拟议的研究旨在表征30个超重饮食中的超重儿童中涉及的神经记录，而没有LOC的30个超重和15个正常重量控制。参与者将完成认知重新评估任务，而位于MRI扫描仪中，其目的是表征重新评估与情感维护控制条件中涉及的中性活动。拟议的研究旨在促进该领域对超重儿童饮食性质和相关性的理解，以便为干预开发提供信息。该研究还符合申请人职业发展目标的更广泛背景。候选人是精神病学和行为神经科学的助理教授，其研究计划的重点是小儿饮食和体重疾病，尤其是暴饮暴食及其与负面影响的关系。为期4年培训计划的总体目标是将候选人确立为独立研究者。具体的培训活动将集中于对整个儿童和青少年的情绪调节涉及的神经记录有足够的了解，以便能够利用发展的神经科学框架来探测饮食失调的饮食；并获得收集，分析和解释fMRI数据的经验。 Mentalship团队由国际知名的发育心理病理学，情感神经科学以及儿科饮食和体重疾病专家组成，他们将对培训计划提供概念监督，并为申请人的职业轨迹提供护理。研究和培训活动将进行 在芝加哥大学精神病学和行为神经科学与大脑成像研究中心的工作。该职业发展奖将填补候选人培训的空白，以扩大她在儿科肥胖症和饮食失调方面的专业知识，最终指导研究计划针对这些问题开发新的干预措施，并支持她过渡到独立的临床研究者。

项目成果

Outcome parameters associated with perceived helpfulness of family-based treatment for adolescent eating disorders.

• DOI: 10.1002/eat.22863
• 发表时间: 2018-06
• 期刊: The International journal of eating disorders
• 作者: Singh S;Accurso EC;Hail L;Goldschmidt AB;Le Grange D
• 通讯作者: Le Grange D

Could the resource depletion model of self-control help the field to better understand momentary processes that lead to binge eating?

• DOI: 10.1002/eat.22641
• 发表时间: 2016-11-01
• 期刊: INTERNATIONAL JOURNAL OF EATING DISORDERS
• 影响因子: 5.5
• 作者: Loth, Katie A.;Goldschmidt, Andrea B.;Vohs, Kathleen D.
• 通讯作者: Vohs, Kathleen D.

The utility of DSM-5 indicators of loss of control eating for the bariatric surgery population.

• DOI: 10.1002/erv.2737
• 发表时间: 2020-07
• 期刊: European eating disorders review : the journal of the Eating Disorders Association
• 作者: Conceição EM;de Lourdes M;Peixoto AP;Pinto-Bastos A;Goldschmidt AB;Vaz AR
• 通讯作者: Vaz AR

Conceptualizing and studying binge and loss of control eating in bariatric surgery patients-time for a paradigm shift?

• DOI: 10.1016/j.soard.2016.09.008
• 发表时间: 2016-09-01
• 期刊: SURGERY FOR OBESITY AND RELATED DISEASES
• 影响因子: 3.1
• 作者: Goldschmidt, Andrea B.;Conceicao, Eva M.;Bond, Dale S.
• 通讯作者: Bond, Dale S.

Maternal Eating Behavior and Problematic Eating Behaviors of Children Undergoing Weight Loss Treatment: A Cluster Analysis.

母亲的饮食行为和接受减肥治疗的儿童的问题饮食行为：聚类分析。

• DOI: 10.1089/chi.2020.0094
• 发表时间: 2020
• 期刊: Childhood obesity (Print)
• 作者: Ramalho,Sofia;Félix,Sílvia;Goldschmidt,AndreaB;Silva,Diana;Costa,Cristiana;Mansilha,HelenaFerreira;Conceição,EvaM
• 通讯作者: Conceição,EvaM