Investigation of Momentary, Prospective Associations Between Working Memory and Eating Behavior in Children

儿童工作记忆与饮食行为之间的瞬时、前瞻性关联的调查

• 批准号: 10452888
• 负责人: Andrea Beth Goldschmidt
• 金额: $ 3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-24 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452888
• 关键词: Investigation; Momentary; Prospective; Associations; Between

PROJECT SUMMARY/ABSTRACT - NO CHANGE FROM ORIGINAL Pediatric overweight and obesity continue to be major public health issues. Loss of control (LOC) eating is an obesity-related phenotype that affects approximately 30% of children and adolescents with overweight/obesity and may impede successful weight control. Both pediatric overweight/obesity and LOC eating are associated with relative deficiencies in executive functioning. In particular, our recently published data suggest that youth with LOC eating and concomitant overweight/obesity have poorer working memory (WM) than their overweight/obese and non-overweight peers. These decrements may inhibit their abilities to adaptively respond to environmental and internal cues related to eating. A limitation of prior research is that it has largely focused on individual differences in neurocognitive processes, thereby failing to inform our understanding of how these processes may drive eating behavior on a moment-to-moment basis and limiting development of interventions that can be delivered in real time when individuals are most at risk for engaging in LOC eating. This R03 application proposes to use ecological momentary assessment (EMA) and validated dietary assessment (Nutritional Database System for Research; NDSR) to assess eating behavior in the context of acute WM, and assess whether fluctuations in WM are related to LOC eating or excess energy intake in children (10-17 years) with LOC eating and overweight/obesity relative to their overweight/obese and non- overweight peers. The applicant is a current K23 recipient (DK-105234) whose program of research has focused on clarifying the etiology and maintenance of LOC eating in youth with overweight/obesity. The applicant's expertise in momentary assessment of affective and neurocognitive processes underlying eating- and weight-related disorders forms the basis of the current proposal. In particular, the applicant has extensive experience utilizing EMA to understand antecedents and consequences of maladaptive eating in near real time in the natural environment. EMA is ideal for investigating eating behavior in the context of WM as it allows for prospective, momentary assessment of within- and between-person variables of interest. In the proposed study, participants will monitor their eating behavior via EMA for 14 days, and dietary recalls completed on 3 randomly selected days during this same period. They will also complete EMA tasks of numerical and spatial WM. Data on potential covariates (e.g., mood) will also be collected via EMA. These data will clarify timing and trajectory of LOC eating and dietary intake in relation to WM performance. This study, which is the first to use EMA to clarify if momentary WM performance is related to eating behavior, has clear potential to advance scientific and clinical understanding of mechanisms that promote the occurrence of maladaptive eating in youth and inform interventions to alleviate their cumulative personal and societal burden. Furthermore, this proposal provides a clear pathway to independence for the investigator, and will enable her to pursue future R01 funding to understand the impact of WM training on eating- and weight-related outcomes.

项目摘要/摘要 - 没有原始的变化 小儿超重和肥胖仍然是主要的公共卫生问题。失去控制（LOC）饮食是 肥胖相关的表型影响大约30％的超重/肥胖症儿童和青少年 并可能阻碍成功的体重控制。小儿超重/肥胖和LOC饮食都是相关的 在执行功能方面的相对缺陷。特别是，我们最近发布的数据表明青年 与LOC饮食和伴随的超重/肥胖相比，工作记忆较差（WM） 超重/肥胖和非重量同伴。这些减少可能会抑制它们适应的能力 应对与饮食有关的环境和内部提示。先前研究的一个局限性是它在很大程度上具有 专注于神经认知过程中的个体差异，因此未能告知我们对 这些过程如何瞬间推动饮食行为，并限制 当个人最有可能从事LOC饮食的风险时，可以实时提供的干预措施。 此R03应用建议使用生态时刻评估（EMA）并验证了饮食 评估（研究的营养数据库系统； NDSR），以评估饮食行为 急性WM，并评估WM中的波动是否与LOC饮食或过量能量摄入有关 儿童（10-17岁），相对于他们的超重/肥胖和非 - 饮食和超重/肥胖 超重的同龄人。申请人是当前的K23收件人（DK-105234），其研究计划已有 专注于阐明超重/肥胖症青年的病因和维持LOC饮食的病因和维护。这 申请人在瞬间评估情感和神经认知过程中的专业知识 - 与体重有关的疾病构成了当前提案的基础。特别是，申请人有广泛的 利用EMA了解不良适应性饮食的先例和后果的经验 在自然环境中。 EMA非常适合在WM的背景下调查饮食行为，因为它允许 对感兴趣的人内部和中间变量的前瞻性，瞬间评估。在提议中 研究，参与者将通过EMA监视他们的饮食行为14天，而饮食召回已完成3 在同一时期内随机选择的日子。他们还将完成数值和空间的EMA任务 Wm。潜在协变量（例如，情绪）的数据也将通过EMA收集。这些数据将阐明时间和 与WM性能有关的LOC饮食和饮食摄入量的轨迹。这项研究，这是第一个使用的研究 EMA澄清瞬时WM表现是否与饮食行为有关，具有明确的推进潜力 对促进青年不良适应性饮食发生的机制的科学和临床理解 并告知干预措施以减轻其累积的个人和社会负担。此外，该提议 为调查员提供了独立的明确途径，并将使她能够追求未来的R01资金 了解WM培训对饮食和体重有关的结果的影响。