Precision Medicine: Moving Theory into Practice

精准医学：将理论付诸实践

• 批准号: 9752826
• 负责人: DANA P GOLDMAN
• 金额: $ 4.24万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752826
• 关键词: Precision; Medicine; Moving; Theory; into

ABSTRACT This research development workshop will provide a collaborative environment for members of the regulatory, economic, payer, clinical, and scientific communities to discuss the utility and limitations of personalized and precision medicine (PPM) and challenges associated with its implementation into health care systems. As an exemplar, we will apply the above perspectives to autoimmune and inflammatory diseases, a rapidly evolving specialty within PPM, in effort to extend PPM beyond oncology and other specialties to which is it commonly applied. The workshop will have the following four aims: 1) We will examine PPM approaches, with an emphasis on those used in autoimmune and inflammatory disease care, from a broad range of perspectives to examine their utility and limitations. The goal will be to determine which approaches—if any—are most likely to fulfill the theoretical promises of PPM when implemented into health care systems. 2) With input from key health care systems stakeholders, we will explore possible considerations and challenges associated with implementing PPM approaches into health care systems. We will then propose an action plan to guide the implementation of the most promising PPM approaches into clinical care. 3) We will develop a research agenda to set priorities for future studies. This agenda will summarize the workshop conclusions and provide a framework for future studies to expand on these findings to better understand the utility and limitations of PPM approaches and accelerate the development and implementation of PPM into standard clinical care. 4) We will develop a Young Investigator Program to motivate a diverse group of students and young investigators to pursue careers in PPM research. Our Program will allow for collaborative networking and exchange of knowledge and ideas among young and established investigators, with the goal of encouraging young investigators to pursue research careers related to PPM, and ultimately submit grant proposal to AHRQ solicitations and contribute to the scientific literature. Overall, this workshop will provide critical new insights and a framework for future research to advance the understanding of PPM and accelerate the development and implementation of PPM into standard clinical care, as well as explore the challenges of implementing PPM approaches into health care systems and strategies for overcoming these challenges.

抽象的 该研究开发研讨会将为监管成员提供协作环境， 经济，付款人，临床和科学社区，讨论个性化和 精密医学（PPM）及其在医疗保健系统中实施的挑战。作为 示例性，我们将把上述观点应用于自身免疫性和炎症性疾病，这是一种快速发展的 PPM内的专业，旨在将PPM扩展到肿瘤学和其他专业之外 应用。研讨会将具有以下四个目标：1）我们将研究PPM的方法，重点 关于自身免疫和炎症性疾病护理的那些，从广泛的角度检查 他们的实用性和局限性。目标是确定哪种方法（如果有的话）最有可能实现 PPM实施到医疗保健系统时的理论承诺。 2）来自关键医疗保健的输入 系统利益相关者，我们将探讨与实施相关的可能考虑因素和挑战 PPM进入医疗保健系统。然后，我们将提出一项行动计划，以指导实施 最有希望的PPM进入临床护理。 3）我们将开发一项研究Agernda，以确定优先事项 未来的研究。该议程将总结研讨会的结论，并为将来的研究提供框架 扩展这些发现，以更好地了解PPM方法的实用性和局限性并加速 PPM开发和实施到标准的临床护理中。 4）我们将发展一个年轻的调查员 计划激励一群学生和年轻调查人员参加PPM研究的计划。 我们的计划将允许在年轻和 成熟的研究人员，目的是鼓励年轻的研究人员从事与研究事业相关的 向PPM，最终向AHRQ征集提出赠款建议，并为科学文献做出贡献。 总体而言，该研讨会将为未来的研究提供关键的新见解和框架 了解PPM并加速PPM在标准临床护理中的开发和实施， 以及探索将PPM方法实施到医疗保健系统中的挑战和策略 克服这些挑战。