The Long-Term Benefits of Interventions to Improve T2D Outcomes

改善 T2D 结局的干预措施的长期益处

基本信息

批准号：
9176837
负责人：
DANA P GOLDMAN
金额：
$ 69.01万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-22 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9176837
关键词：
Accounting Adherence Admission activity Affect Amputation Blindness Body Weight decreased Cardiovascular system Clinical Clinical Trials Control Groups Data Data Linkages Dementia Diabetes Mellitus Direct Costs Disability Insurance Disease Disease Management Disease remission Economics Education Employment Enrollment Epidemiologist Etiology Goals Guidelines Health Health Care Costs Health Services Accessibility Healthcare Systems Heart Diseases Hospitals Hypertension Income Intervention Investments Kidney Failure Knowledge Lead Life Link Measures Medicare Medicare claim Modeling Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Patients Physicians Population Public Assistance Public Health Quality of life Randomized Records Regimen Research Retirement Running Sleep Apnea Syndromes Societies Socioeconomic Status Sorting - Cell Movement Source Stroke United States Social Security Administration Weight Work abstracting cardiovascular risk factor data modeling design diabetes control diabetes management diet and exercise disability economic impact economic implication economic outcome experience follow-up functional status health care service utilization health economics health related quality of life improved intervention effect lifestyle intervention mortality multidisciplinary social successful intervention weight loss intervention

项目摘要

Project Summary/ Abstract Diabetes is a mounting public health concern, with millions of new cases each year. Poor control of diabetes is associated with serious health complications, including heart disease, blindness, and amputation. Control of diabetes can be achieved through adherence to diet, exercise, and treatment guidelines, but compliance with prescribed regimens can be complicated and difficult. The Look AHEAD study randomized an intensive lifestyle intervention focused on weight reduction among over 5,000 patients with type 2 diabetes in 2001. Participants in the intervention lost weight and improved their diabetes control over the 11 years of the intervention relative to the control group. Weight reductions and improvements in diabetes outcomes may lead to broader benefits for patients in terms of functional status, ability to work, and fewer health complications. We propose research linking Look AHEAD participants with data from Medicare and the Social Security Administration to determine the effect of the intervention on long-term health care utilization (e.g. hospital admissions), employment, earnings, retirement, and severe disability (as measured by enrollment in disability insurance). In addition, we will simulate the long-term fiscal impacts of a broader, national expansion of the intensive lifestyle intervention. Finally, we will compare health and disability measures collected by the Look AHEAD study to overlapping measures in Medicare and the Social Security Administration data, to evaluate the use of administrative data as a source of health information in clinical trials. The results of this study will provide important evidence on the broader benefits of successful lifestyle interventions for diabetes. In addition, the results will indicate the impact of improved diabetes control on functional status and economic outcomes.

项目摘要/摘要糖尿病是一个越来越多的公共健康问题，每年有数百万个新病例。对糖尿病的控制不良是与严重的健康并发症有关，包括心脏病，失明和截肢。控制糖尿病可以通过遵守饮食，运动和治疗指南来实现，但要符合规定的方案可能很复杂且困难。未来的研究随机进行密集 2001年，超过5,000例2型糖尿病患者的生活方式干预措施重量减轻。干预的参与者减轻了体重，并改善了糖尿病的控制相对于对照组的干预。减轻体重和糖尿病结局的改善可能会导致就功能状况，工作能力和更少的健康并发症而言，为患者提供更广泛的好处。我们提出研究链接的研究参与者与Medicare和社会保障的数据管理确定干预对长期医疗保健利用的影响（例如医院招生），就业，收入，退休和严重残疾（通过残疾入学率衡量保险）。此外，我们将模拟更广泛的国家扩张的长期财政影响密集的生活方式干预。最后，我们将比较外观收集的健康和残疾措施在Medicare和社会保障局数据中重叠的措施进行重叠的研究，以评估在临床试验中，使用行政数据作为健康信息的来源。这项研究的结果将提供有关糖尿病成功生活方式干预措施的更广泛好处的重要证据。在此外，结果将表明改善糖尿病控制对功能状况和经济状况的影响结果。