Moving Mindfully: A MBSR-Centered Approach to Freezing in Parkinson Disease

正念前行：以 MBSR 为中心的帕金森病冷冻疗法

基本信息

批准号：
10217776
负责人：
GAMMON M. EARHART
金额：
$ 24.97万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10217776
关键词：
Address Adherence Affective Anxiety Applications Grants Area Awareness Basal Ganglia Benchmarking Brain Stem Caring Cerebellum Chronic Clinical Trials Cognitive Compassion Complementary Health Conscious Corpus striatum structure Data Development Diagnosis Education Educational process of instructing Elderly Elements Emotional Ensure Evaluation Evidence based practice Evidence based treatment Exhibits Feedback Freezing Frustration Funding Opportunities Future Gait Goals Grant Health Hip Fractures Individual Integrative Medicine Intention Intervention Judgment Lead Limbic System Malignant Neoplasms Measures Mediation Medical Meditation Mental Depression Mental Health Mind-Body Intervention Mindfulness Training Monitor Motor Motor Cortex Movement Neurologic Nucleus Accumbens Outcome Outcome Assessment Pain Parkinson Disease Participant Patients Phase Plant Roots Population Protocols documentation Quality of life Randomized Randomized Controlled Trials Reporting Research Research Priority Series Social Interaction Standardization Stress Stroke Symptoms Technology Testing Walking Work acceptability and feasibility adverse event monitoring anxiety symptoms associated symptom base disabling symptom effectiveness trial experience fall risk falls fear of falling follow-up improved improved mobility information gathering instructor meetings member mindfulness mindfulness intervention mindfulness-based stress reduction mortality neural circuit neurochemistry novel physical therapist prevent programs psychologic psychological distress recruit relating to nervous system resilience response satisfaction sedentary lifestyle treatment as usual treatment group treatment trial walking intervention

项目摘要

ABSTRACT This planning grant application is in response to the R34 funding opportunity sponsored by the National Center for Complementary and Integrative Health (NCCIH) titled Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics, PAR-18-417. Here we will modify and evaluate the feasibility of a mindfulness intervention among people living with Parkinson disease (PD) and freezing of gait (FOG). FOG is a severe motor disturbance that prevents people from stepping normally and is associated with anxiety, frustration, sedentary behaviors, poorer quality of life, and falls. Mindfulness-Based Stress Reduction (MBSR) is an evidence-based practice that creates a culture to reduce stress and anxiety by increasing conscious awareness and self-compassion. In this study, we propose developing a mindfulness-based walking intervention to address both mental health and mobility challenges that constitute FOG. This R34 includes three aims to permit the development of a mind and body approach for FOG among people living with PD. In Aim 1 we will form an advisory group of study team members, physical therapists, mindfulness instructors, and patient stakeholders. The advisory group will adapt the current MBSR Program to develop and deliver a mindfulness-based treatment that emphasizes walking meditations and is safe and applicable for people living with PD and FOG. In Aim 2 we open pilot the modified program, Mindfulness-Based Walking Therapy (MBWT). MBWT will be modified per feedback from instructors and participants. The end result of Aim 2 will be a standardized MBWT program. In Aim 3 we will pilot the standardized MBWT program in an individually randomized group treatment trial. People who experience FOG will be randomized to receive MBWT or usual care. Usual care will include medical management and education regarding freezing of gait. Feasibility parameters to meet benchmarks regarding recruitment, randomization, retention, satisfaction, delivery of intervention, adherence, and burden of outcomes will be collected during both Aim 2 and Aim 3.

抽象的该规划拨款申请是为了响应国家补充和综合健康中心 (NCCIH) 赞助的 R34 资助机会，题为 NCCIH 高优先研究主题的身心干预可行性临床试验，PAR-18-417。在这里，我们将修改和评估对帕金森病（PD）和冻结步态（FOG）患者进行正念干预的可行性。 FOG 是一种严重的运动障碍，会阻碍人们正常行走，并与焦虑、沮丧、久坐行为、生活质量较差和跌倒有关。基于正念的减压 (MBSR) 是一种基于证据的实践，它创建一种通过增强自觉意识和自我同情来减轻压力和焦虑的文化。在这项研究中，我们建议开发一种基于正念的步行干预措施，以解决构成 FOG 的心理健康和行动能力挑战。该 R34 包括三个目标，旨在为 PD 患者制定一种针对 FOG 的身心方法。在目标 1 中，我们将组建一个由研究团队成员、物理治疗师、正念教练和患者利益相关者组成的咨询小组。该咨询小组将调整当前的 MBSR 计划，开发和提供一种基于正念的治疗方法，强调步行冥想，并且安全且适用于 PD 和 FOG 患者。在目标 2 中，我们开放试点修改后的计划：基于正念的步行疗法 (MBWT)。 MBWT 将根据讲师和参与者的反馈进行修改。目标 2 的最终结果将是标准化的 MBWT 计划。在目标 3 中，我们将在单独随机分组治疗试验中试行标准化 MBWT 计划。经历过 FOG 的人将被随机分配接受 MBWT 或常规护理。常规护理包括医疗管理和有关步态冻结的教育。将在目标 2 和目标 3 期间收集满足有关招募、随机化、保留、满意度、干预实施、依从性和结果负担等基准的可行性参数。