Innovations in Pediatric Pain Research

小儿疼痛研究的创新

• 批准号: 8634406
• 负责人: Tonya M Palermo
• 金额: $ 17.71万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8634406
• 关键词: Abdominal Pain; Achievement; Adolescent; Adult; Affect; Aftercare; Anesthesiology; Anxiety; Area; Award; Behavior Therapy; Caregivers; Child; Childhood; Clinical Research; Clinical Trials; Clinical Trials Design; Cognitive Therapy; Collaborations; Conduct Clinical Trials; Coping Skills; Data; Development; Distress; Economic Burden; Educational process of instructing; Emotional; Emotional Stress; Environment; Evaluation; Face; Faculty; Family; Fellowship; Fostering; Functional disorder; Funding; Goals; Grant; Health; Health Services; Health Services Accessibility; Individual; Internet; Intervention; Intervention Studies; Knowledge; Leadership; Measurable; Measurement; Medical center; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal Pain; NCI Scholars Program; National Institute of Child Health and Human Development; Online Systems; Outcome; Pain; Pain Measurement; Pain Research; Pain management; Parenting behavior; Parents; Patient Education; Perioperative; Physical Function; Physical activity; Play; Postdoctoral Fellow; Problem Solving; Psychology; Psychophysics; Publications; Quality of life; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Activity; Research Personnel; Research Support; Research Training; Risk Factors; Role; Science; Services; Site; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Functioning; Social Impacts; Solutions; Stress; Symptoms; Testing; Time; Training; Training Programs; United States National Institutes of Health; Universities; Washington; Work; Writing; Youth; actigraphy; career; chronic pain; coping; cost; cost effective; diaries; disability; economic cost; economic impact; effective intervention; effective therapy; efficacy testing; evidence base; experience; flexibility; follow-up; improved; improved functioning; innovation; innovative technologies; medical specialties; modifiable risk; next generation; parental role; patient oriented; patient oriented research; post-doctoral training; programs; psychologic; public health relevance; skills; skills training; social; standard of care; therapy design; therapy development; tool; treatment effect; treatment response

PROJECT SUMMARY This is a competitive renewal of K24HD060068. An estimated 20% to 40% of otherwise healthy children and adolescents suffer from chronic pain such as abdominal and musculoskeletal pain. Many of these children also experience significant sleep disturbances. Chronic pain and associated symptoms (such as sleep problems) results in a measurable decline in children's quality of life and produces stress and economic burden on parents and families. Increasingly, cognitive-behavioral therapies (CBT) are emerging as effective interventions for pediatric chronic pain. Because children and families face challenges accessing specialty services such as CBT for chronic pain, innovative technologies may be a solution for broadening access to care. The candidate's research activities during the prior period of K24 support focused on three areas: sleep-wake disturbances, behavioral interventions, and assessment of physical activity and function. Significant progress and achievements were made during the prior period of support in publications, new grants awarded, mentorship of fellows and junior faculty, career advancement, and academic leadership. The primary objectives of this renewal application for a Midcareer Investigator Award in Patient-Oriented Research are for the candidate to fully develop and evaluate innovative, cost-effective psychological treatments to decrease pain and sleep disturbances, and improve functioning in children and adolescents with chronic pain; to expand research knowledge of psychophysical pain assessment; and to teach new clinicians the skills necessary for developing innovative research in pediatric pain and supporting them in their transition to research independence. Over the next period of K24 support, the candidate will complete studies funded with current research support including a NIH/NICHD R01 grant to evaluate the efficacy of an internet-delivered behavioral intervention for pediatric chronic pain and disability (Project 1); and a NIH/NICHD R21 grant to develop and test the efficacy of a parental problem solving intervention designed to reduce distress in parent caregivers of youth with chronic pain (Project 2). New research proposed during the award is focused on evaluating the feasibility and preliminary efficacy of CBT for insomnia in youth with chronic pain and sleep disturbances (Project 3). Career objectives in mentoring beginning clinician investigators are to provide training in conducting assessment and intervention research using innovative technologies, to provide direct experience and training in writing grants and obtaining independent research funding, and to foster a career-long commitment to patient-oriented research. Formal didactic programs are available through several university programs including T32 postdoctoral training, a NIH KL2 program, and a Clinical research mentored scholars program. The University of Washington provides an ideal environment with a strong record of interdisciplinary patient-oriented pain research and collaborative science.

项目概要 这是 K24HD060068 的竞争性更新。据估计，20% 至 40% 的健康儿童和 青少年患有慢性疼痛，例如腹部和肌肉骨骼疼痛。这些孩子中的许多人也 经历严重的睡眠障碍。慢性疼痛和相关症状（例如睡眠问题） 导致儿童生活质量明显下降，并给儿童带来压力和经济负担 父母和家人。认知行为疗法 (CBT) 日益成为有效的干预措施 用于小儿慢性疼痛。因为儿童和家庭在获得专业服务方面面临挑战，例如 针对慢性疼痛的 CBT 创新技术可能是扩大护理机会的解决方案。这 候选人在 K24 支持前期的研究活动主要集中在三个领域：睡眠-觉醒 干扰、行为干预以及身体活动和功能的评估。重大进展 以及在先前的出版物支持期间取得的成就，授予的新赠款， 对研究员和初级教师的指导、职业发展和学术领导力。初级 此次续签以患者为导向的研究中职业生涯研究者奖的申请的目的是 候选人充分开发和评估创新的、具有成本效益的心理治疗方法，以减少 疼痛和睡眠障碍，并改善患有慢性疼痛的儿童和青少年的功能；扩大 心理物理疼痛评估的研究知识；并教授新临床医生必要的技能 开展儿科疼痛方面的创新研究并支持他们向研究过渡 独立。在 K24 支持的下一个时期，候选人将完成由当前资金资助的研究 研究支持，包括 NIH/NICHD R01 拨款，用于评估互联网提供的行为的有效性 对儿科慢性疼痛和残疾的干预（项目 1）；以及 NIH/NICHD R21 拨款，用于开发和 测试旨在减少父母照顾者痛苦的父母问题解决干预措施的有效性 患有慢性疼痛的青少年（项目 2）。颁奖期间提出的新研究重点是评估 CBT治疗患有慢性疼痛和睡眠障碍的青少年失眠的可行性和初步疗效 （项目3）。指导初级临床医生研究者的职业目标是提供以下方面的培训： 利用创新技术进行评估和干预研究，提供直接经验 以及撰写资助和获得独立研究经费方面的培训，并培养长期的职业生涯 致力于以患者为中心的研究。几所大学提供正式的教学课程 项目包括 T32 博士后培训、NIH KL2 项目和临床研究指导学者 程序。华盛顿大学提供了一个理想的环境，拥有良好的跨学科记录 以患者为中心的疼痛研究和协作科学。