Risk Factors for Barrett's Esophagus

巴雷特食管的危险因素

基本信息

批准号：
8484838
负责人：
BRIAN C JACOBSON
金额：
$ 39.73万
依托单位：
BOSTON MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8484838
关键词：
ABO blood group system Address Anti-Inflammatory Agents Anti-inflammatory Archives Aspirin Barrett Esophagus Blood specimen Body mass index C-Peptide C-reactive protein Cell Line Characteristics Chronic Cohort Studies Collection Columnar Epithelium Data Development Diagnosis Diet Dietary Practices Drug usage Endoscopy Epidemic Esophageal Adenocarcinoma Esophagus Excision Fatty acid glycerol esters Frequencies Functional disorder Funding Gastroesophageal reflux disease Gender Genes Genetic Variation Genotype Goals Grant Growth Factor Health Professional Histologic Hyperinsulinism Incidence Individual Inflammation Inflammation Mediators Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Like Growth-Factor-Binding Proteins Intake Intercellular adhesion molecule 1 Interleukin-6 Intestines K-Series Research Career Programs Lead Leptin Life Style Malignant Neoplasms Measures Meat Mediating Modification Nurses&apos Health Study Obesity Overweight Pathogenesis Persons Plasma Polyunsaturated Fatty Acids Premalignant Prospective Studies Proteins Records Reflux Reporting Research Research Personnel Resources Retrospective Studies Risk Risk Factors Role Serum Squamous Cell Squamous Epithelium Stomach Symptoms TNF gene Time Tumor Necrosis Factor Receptor Tumor Necrosis Factor-alpha United States Western Europe Woman adiponectin cancer type cohort disease diagnosis energy balance follow-up fruits and vegetables indexing men novel prospective public health relevance sedentary

项目摘要

DESCRIPTION (provided by applicant): The incidence of esophageal adenocarcinoma has been rising rapidly over the past two decades for unclear reasons. The most important risk factor for this cancer is Barrett's esophagus, a condition resulting from the reflux of gastric contents into the esophagus. In Barrett's esophagus the normal squamous cell lining of the esophagus is replaced by a specialized cell lining containing intestinal features. Risk factors associated with the development of Barrett's esophagus are not well defined. Furthermore, while men and women report symptoms of gastroesophageal reflux with equal frequency, men are twice as likely to develop Barrett's esophagus, suggesting gender-associated modifications of underlying risk factors. We propose to utilize the resources of three large, ongoing cohort studies, the Nurses' Health Study I, the Nurses' Health Study II, and the Health Professionals' Follow-up Study, to investigate inter-related mechanisms among both men and women that may contribute to Barrett's esophagus, including the roles of energy balance, insulin resistance, and chronic inflammation. All three cohorts provide prospectively collected data on potential risk factors for Barrett's esophagus, archived pre-diagnosis blood samples, and detailed endoscopy records and validated data on histologically-documented Barrett's esophagus. This unique investigative opportunity will allow us to examine, in detail, the associations between diet; gender; circulating levels of insulin, insulin derived growth factor, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, c-reactive protein, and other markers of insulin resistance and systemic inflammation; and other novel influences on the pathogenesis of Barrett's esophagus.

描述（由申请人提供）：过去二十年，食管腺癌的发病率迅速上升，原因尚不清楚。这种癌症最重要的危险因素是巴雷特食管，这是一种由胃内容物反流到食管引起的疾病。在巴雷特食管中，食管的正常鳞状细胞内壁被含有肠道特征的特殊细胞内壁所取代。与巴雷特食管发展相关的危险因素尚不明确。此外，虽然男性和女性报告胃食管反流症状的频率相同，但男性患巴雷特食管的可能性是男性的两倍，这表明潜在危险因素的性别相关改变。我们建议利用三项正在进行的大型队列研究（护士健康研究 I、护士健康研究 II 和卫生专业人员随访研究）的资源来调查男性和女性之间的相互关联机制，可能会导致巴雷特食管，包括能量平衡、胰岛素抵抗和慢性炎症的作用。所有三个队列都提供了有关巴雷特食管潜在危险因素的前瞻性收集数据、存档的诊断前血样以及详细的内窥镜检查记录和组织学记录的巴雷特食管的验证数据。这个独特的研究机会将使我们能够详细研究饮食之间的关联；性别;胰岛素、胰岛素衍生生长因子、瘦素、脂联素、白细胞介素 6、肿瘤坏死因子 α、C 反应蛋白以及其他胰岛素抵抗和全身炎症标志物的循环水平；以及对巴雷特食管发病机制的其他新影响。