Optical Scatter Imaging System for Surgical Specimen Margin Assessment during Breast Conserving Surgery

光学散射成像系统用于保乳手术中手术标本边缘评估

• 批准号: 9211221
• 负责人: KEITH D. PAULSEN
• 金额: $ 52.49万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9211221
• 关键词: Algorithmic Software; Algorithms; American; Blinded; Blood; Breast; Breast-Conserving Surgery; Cancer Detection; Classification; Clinical; Collaborations; Collection; Computer Assisted; Computer software; Consensus; Cost Control; Coupled; Data; Data Set; Decision Making; Devices; Diagnostic; Diagnostic radiologic examination; Disease remission; Electrons; Engineering; Excision; Face; Frequencies; Frozen Sections; Future; Grant; Health; Health Care Costs; Human Resources; Image; Ink; Institutes; Intellectual Property; Intervention Studies; Ipsilateral; Label; Lateral; Lesion; Light; Liquid substance; Malignant Neoplasms; Mammography; Medical; Meta-Analysis; Methods; Microscopic; Modality; Molecular; Morphology; Noninfiltrating Intraductal Carcinoma; Operative Surgical Procedures; Optics; Outcome; Pathology; Patients; Performance; Phase; Procedures; Property; Publishing; Radiation Oncology; Recurrence; Reporting; Research; Resected; Residual Cancers; Risk; Scanning; Side; Signal Transduction; Societies; Software Engineering; Specimen; Spectrum Analysis; Structure; Surface; Surgeon; Surgical Oncology; Surgical margins; System; Systems Development; Systems Integration; Technology; Testing; Time; Tissue Banks; Tissue Sample; Tissue imaging; Tissues; Training; Uncertainty; Validation; Woman; Work; X-Ray Computed Tomography; base; breast imaging; breast lesion; breast malignancies; cancer imaging; cohort; design; experience; image processing; imaging approach; imaging study; imaging system; in situ imaging; industry partner; innovation; medical schools; medical specialist; microCT; pre-clinical; prospective; prototype; public health relevance; spectroscopic imaging; translational study

 DESCRIPTION (provided by applicant): Breast conserving surgery is routinely offered for localized breast malignancies, but has a known problem of uncertainty about if the entire cancer has been removed. Today, approximately one third of all patients are recalled for a second re-excision because either residual cancer or DCIS was found on the specimen surface or within 1-2 mm of it, when analyzed in pathology in the days after the initial procedure. There is a need for an accurate surgeon assist device, which can determine the potential that the resected specimen is clear of cancer at the margins. This can be directly solved through a technological solution which is optimized for wide- field and volumetric scanning, coupled with computer-aided decision making. In this academic-industry partnership, wide-field optical scatter spectroscopic imaging is coupled to volumetric CT scanning of specimens, in a package which integrates a substantial pre-clinical experience by the PerkinElmer team, with substantial prototyping and clinical specimen imaging work of the Dartmouth team. Scatter imaging allows surface scanning through high-spatial frequency imaging of the tissue, which negates erroneous signals from blood, fluid or ink on the tissue surface, which is critically important for fast in situ imaging o large tissue fields. This will be coupled with fast volumetric CT imaging in integrated display software. The surface molecular- structural features are key to identifying potential cancer regions for the surgeon, as is the volumetric CT key to identifying the internal tracks of the cancer which were seen on mammography and can be used to help identify which faces of the specimen are closest to the internal lesion. The combined system will be completed in the first few years, and tested for training data sets on known tissue samples from the breast lesion tissue bank. Following validation, a prospective trial will be carried out on the system, to help determine the accuracy in margin identification. Taken together this will be one of the first comprehensive approaches to volumetric and surface scanning in a single package, and comes from two groups with substantial experience in the aspects of cancer imaging and system development.

 描述（由适用提供）：通常为局部乳腺恶性肿瘤提供乳房保存手术，但对于是否已切除了整个癌症存在不确定性问题。如今，大约三分之一的患者被召回第二次重新筛选，因为在初始手术后的几天内对病理学进行了分析时，在样品表面或其1-2 mm内发现了残留癌或DCI。需要精确的外科医生辅助装置，该设备可以确定切除的样品在边缘没有癌症的潜力。这可以通过技术解决方案直接解决，该技术解决方案可针对宽场和体积扫描进行优化，再加上计算机AID决策。在这种学术行业伙伴关系中，宽场光学散射光谱成像与标本的体积CT扫描结合在一起，该包装包含了Perkinelmer团队的实质前临床体验，并具有实质性的原型和临床标本的成像工作。散射成像可以通过组织的高空间频率成像进行表面扫描，从而消除了组织表面上血液，流体或墨水的错误信号，这对于快速的原位成像非常重要。这将与集成显示软件中的快速体积CT成像相结合。表面分子结构特征是鉴定外科医生潜在癌症区域的关键，并且体积CT的键是识别乳腺造影术的癌症的内部轨道，并可用于帮助识别样品的哪些面封闭于内部病变。合并系统将在最初的几年完成，并在乳腺病变组织库的已知组织样品上测试了训练数据集。验证后，将对系统进行前瞻性试验，以帮助确定保证金识别的准确性。一起，这将是单个包装中体积和表面扫描的首批综合方法之一，并且来自两组在癌症成像和系统开发方面具有丰富经验的群体。