Spectrally optimized, Spatially resolved Poro and Viscoelastic Brain MRE

光谱优化、空间分辨的 Poro 和粘弹性脑 MRE

• 批准号: 8738671
• 负责人: KEITH D. PAULSEN
• 金额: $ 33.41万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738671
• 关键词: Alzheimer' s Disease; Animal Model; Animals; Biological Models; Blood; Blood Vessels; Brain; Brain imaging; Canis familiaris; Cerebrovascular system; Clinical; Data; Demyelinations; Development; Edema; Evaluation; Evaluation Studies; Family Felidae; Family suidae; Frequencies; Head; Human; Hydrocephalus; Image; Imaging Techniques; Intracranial Hypertension; Liquid substance; Magnetic Resonance Elastography; Maps; Mechanics; Methods; Modeling; Motion; Multiple Sclerosis; Neurologic; Performance; Property; Radiation; Recovery; Relative (related person); Reporting; Resolution; Series; Study Subject; System; Techniques; Tissues; Venous; base; cerebrovascular; comparative; design; image reconstruction; imaging modality; in vivo; innovation; interest; interstitial; nervous system disorder; novel strategies; phantom model; pressure; public health relevance; research study; response; vibration

DESCRIPTION (provided by applicant): We have established an innovative approach to brain magnetic resonance elastography (MRE) based on encoding of endogenous low frequency (~1Hz) motion resulting from blood pulsation through the cerebrovascular system that is reconstructed with a poroelastic mechanical model to produce three- dimensional (3D), spatially-resolved mechanical and hydrodynamical property images. Our poroelastic MRE (pMRE) methods have produced promising preliminary data in phantoms, animals, and humans. In parallel, we have advanced substantially our viscoelastic MRE (vMRE) methods based on external high frequency (50- 100Hz) actuation, and preliminary data from our latest vMRE studies in phantoms, animals and humans are also very impressive because of the spatially-resolved mechanical property information that can be obtained. Indeed, we have evidence to suggest that vMRE and pMRE are complementary - namely that vMRE is the method of choice at externally-actuated high frequencies where the viscous damping effects of brain parenchyma are more dominant, whereas pMRE is the best choice at intrinsically-actuated low frequencies where the hydrodynamic fluid effects become more important. Our overall objective in this project is to unify and optimize our pMRE and vMRE methods in order to evaluate them across the frequency spectrum of interest (~1-100Hz) in a series of phantom and animal model systems which will identify the conditions under which they provide superior, comparable and/or complementary images and data. Specifically, we will (1) develop a unified framework and platform through which we will advance and optimize our pMRE and vMRE image reconstruction methods, (2) use actuation and phantom systems for comparative evaluations across the frequency range of interest, and (3) complete experiments in three large animal models with controllable parameters and experimental conditions under which comparative evaluations will occur in vivo. Evidence already exists to support the potential of brain MRE to inform clinical identification and management of multiple neurological disorders. We hypothesize that brain MRE has much more to offer - specifically, that 3D, spectrally-optimized, spatially-resolved maps of tissue mechanical and hydrodynamical properties should be the standard - not the whole/regional brain mechanical property averages that have largely been reported to date. External and intrinsic brain actuation both have merit, as do pMRE and vMRE; hence, a focused and sustained effort to optimize, evaluate and compare these approaches across the available frequency range is needed to identify the methods of choice under selected and prevailing conditions of interest.

描述（由申请人提供）：我们已经建立了一种创新的方法，以基于通过脑血管脉冲系统编码血液脉动而导致的内源性低频（〜1Hz）运动的编码，该运动是通过脑血管脉冲系统改造的，该系统是用毛状弹性机械模型重新结构的，以产生三个尺寸（3D）的特性和构造的机制和固定的机制。我们的孔隙弹性MRE（PMRE）方法在幻象，动物和人类中产生了有希望的初步数据。同时，我们已经基于外部高频（50-100Hz）致动的粘弹性MRE（VMRE）方法，并从我们对幻影，动物和人类的最新VMRE研究中进行了初步数据，因为可以获得可以获得的空间分辨的机械性能信息，因此也非常令人印象深刻。实际上，我们有证据表明VMRE和PMRE是互补的 - 即VMRE是外部驱动高频的选择方法，在外部型高频中，脑实质的粘性阻尼效应更为主导，而PMRE是静脉液体频率的最佳选择，而水力动物液体的影响更为重要。我们在该项目中的总体目标是统一和优化我们的PMRE和VMRE方法，以便在一系列的幻影和动物模型系统中评估它们在感兴趣的频率（〜1-100Hz）中，这些系统将确定它们提供优质，可比和/或互补图像和数据的条件。具体来说，我们将（1）开发一个统一的框架和平台，通过该框架和平台，我们将通过该框架和优化PMRE和VMRE图像重建方法，（2）使用驱动和幻影系统在关注频率范围内进行比较评估，（3）在三个大型动物模型和实验条件下进行比较评估，将在Vivo中进行比较评估。已经存在证据，以支持大脑MRE的潜力，以告知多种神经系统疾病的临床识别和管理。我们假设Brain MRE提供了更多的东西 - 具体来说，组织机械和流体动力学特性的3D，频谱优化的，空间分辨的图应该是标准的 - 不是迄今已在很大程度上报告的整个/区域大脑机械性能平均。外部和内在的大脑致动都具有优点，PMRE和VMRE也是如此。因此，需要在可用频率范围内进行优化，评估和比较这些方法的集中和持续的努力，以确定所选和流行的感兴趣条件下的选择方法。