The Health ePeople Resource for Mobilized Research

用于动员研究的 Health ePeople 资源

• 批准号: 9334228
• 负责人: GREGORY M MARCUS
• 金额: $ 150.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9334228
• 关键词: Architecture; Award; Behavior; Cardiovascular Diseases; Cellular Phone; Characteristics; Clinical Research; Cohort Studies; Computerized Medical Record; Consent; Custom; Data; Data Analytics; Data Base Management; Data Collection; Databases; Devices; Disease; Electronic Health Record; Emerging Technologies; Engineering; Enrollment; Funding; Genetic; Geography; Goals; Health; Health Technology; Human Resources; Image; Institutional Review Boards; Internet; Intervention Trial; Medical Records; Methods; Modeling; Observational Study; Outcome; Participant; Patient Outcomes Assessments; Patient Self-Report; Persons; Population; Prevention strategy; Privacy; Prospective Studies; Randomized; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Safety; Security; Silicon; Structure; Surveys; System; Talents; Technology; Testing; Time; Vision; Work; base; clinical efficacy; cohort; cost effective; dashboard; data integration; data management; data visualization; design; digital; epidemiology study; flexibility; high standard; improved; industry partner; interest; interoperability; mHealth; mobile application; mobile computing; public-private partnership; randomized trial; research study; sensor; success; tool; user-friendly; validation studies

RESOURCE CORE— PROJECT SUMMARY/ABSTRACT We seek to create the Health ePeople Resource, a nimble, readily-accessible, and reliable infrastructure to conduct mHealth research. This effort will build on the current Health eHeart Study, an internet-based clinical research platform that has enrolled more than 20,000 engaged participants from around the world. Although initially developed to study cardiovascular disease, Health eHeart is in use by investigators from multiple fields, and helps us jumpstart many of the objectives set out in the current RFA. We have successfully implemented a user-friendly interface built to collect patient-reported outcomes, validated survey data, and integrations with multiple sensors, devices, and apps; we have an IRB approved system using modular electronic consenting; we have over 20,000 deeply involved participants interested in contributing to mHealth research; we have developed ways for external investigators to utilize and enroll their own participants in a customizable fashion; we have developed a study management portal (including a real-time dashboard and participant characteristic- based filtering system) and a flexible messaging system that can be utilized by external investigators; we have built a database and data management system constructed to adhere to the highest standards of privacy, security, and reliability; and we have iterated and adapted the platform to take advantage of emerging technology and cutting-edge methods. Building from these strengths, we are ready to fully leverage the opportunities afforded by this award, transforming the Health eHeart Study into a general Health ePeople Resource. The Resource Core will be responsible for the following objectives: to expand, improve and iterate upon our participant-facing portal designed to remotely collect self-reported, medical record, device, sensor and mobile data; to expand and improve a redundant, scalable, and fault-tolerant backend and database to reliably curate large quantities of structured and unstructured data; to expand, improve, iterate and maintain a readily accessible interface that enables rapid study implementation for a variety of investigators to customize and utilize a participant portal and backend and database for their mHealth research; to expand, improve and iterate an infrastructure for data analytics, data visualization, and interoperability with external databases; to expand and maintain a cohort of research participants engaged in mHealth that is constructed to provide rapid and customizable selection for observational studies, validation studies, and randomized interventional trials; and finally, to develop and deploy a model to financially and technologically sustain the Health ePeople Resource beyond the proposed funding period.

资源核心——项目摘要/摘要 我们致力于创建 Health ePeople 资源，这是一个灵活、易于访问且可靠的基础设施， 这项工作将建立在当前的 Health eHeart 研究（一项基于互联网的临床研究）的基础上。 研究平台已吸引了来自世界各地的 20,000 多名参与参与者。 Health eHeart 最初是为了研究心血管疾病而开发的，现已被多个领域的研究人员使用， 并帮助我们快速启动当前 RFA 中规定的许多目标。 用户友好的界面旨在收集患者报告的结果、经过验证的调查数据以及与 多个传感器、设备和应用程序；我们拥有 IRB 批准的使用模块化电子同意的系统； 我们有超过 20,000 名有兴趣为移动医疗研究做出贡献的深度参与者； 为外部研究人员开发了以可定制的方式利用和招募自己的参与者的方法； 我们开发了一个研究管理门户（包括实时仪表板和参与者特征- 基于过滤系统）和可供外部调查人员使用的灵活消息系统； 建立了一个数据库和数据管理系统，以遵守最高的隐私标准， 安全性和可靠性；并且我们迭代并调整了该平台以利用新兴技术 凭借这些优势，我们已准备好充分利用这些优势。 该奖项提供的机会，将 Health eHeart 研究转变为一般的 Health ePeople 资源核心将负责以下目标：扩展、改进和迭代。 在我们面向的参与者门户上，旨在远程收集自我报告、医疗记录、设备、传感器 和移动数据；扩展和改进冗余、可扩展和容错的后端和数据库 可靠地管理大量结构化和非结构化数据；扩展、改进、迭代和维护 易于访问的界面，使各种研究人员能够快速实施研究以进行定制 并利用参与者门户、后端和数据库来扩展、改进和开展移动医疗研究； 迭代数据分析、数据可视化以及与外部数据库的互操作性的基础设施； 扩大并维持一批从事移动医疗的研究参与者，旨在提供快速 以及观察性研究、验证性研究和随机干预试验的可定制选择； 最后，开发和部署一个模型，以在财务和技术上维持 Health ePeople 超出拟议资助期限的资源。