ALACRITY for Late- and Mid-Life Mood Disorders

ALACRITY 治疗晚年和中年情绪障碍

• 批准号: 9374695
• 负责人: GEORGE S ALEXOPOULOS
• 金额: $ 142万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9374695
• 关键词: Address; Adherence; Administrator; Adult; Area; Behavior Therapy; Big Data; Biometry; Caring; Clinical; Communities; Community Workers; Complex; Data; Disease; Effectiveness; Elder Abuse; Elderly; Ensure; Funding; Grant; Health Policy; Health Services Research; Healthcare; Incubators; Intervention; Intervention Studies; Lead; Learning; Medical; Mental Health; Methodology; Methods; Mission; Modeling; Monitor; Mood Disorders; Morbidity - disease rate; National Institute of Mental Health; Neurobiology; Persons; Pharmacotherapy; Policies; Population; Poverty; Primary Health Care; Process; Productivity; Quality Control; Research; Research Personnel; Research Training; Site; Structure; Testing; Work; analytical method; base; career development; community intervention; community setting; cost; design; disability; health care model; health economics; improved; innovation; middle age; mobile computing; mortality; novel; social; therapy development; uptake

ALACRITY CENTER ABSTRACT The rapid increase of older persons (73% increase anticipated in US by 2020) and the diseases and disabilities complicating their care make research in this area a national priority. We focus on late- and mid-life mood disorders because they are the leading cause of disability, increase medical morbidity and mortality, cause suffering, and increase the cost of care. Pharmacotherapy addresses the needs of no more than half of these persons and most non-pharmacological therapies are complex and have limited scalability and reach. We propose to put into action a novel model of deployment-based behavioral interventions and implementation, streamlined based on neurobiology models and augmented by mobile technology. Rather than focusing exclusively on uptake and sustainability of available interventions, many of which are too complex for community use, we are working to both simplify the treatments themselves and improve their delivery. Accordingly, our model: 1) Targets groups identified by consumers, community partners, and our team. 2) Develops its interventions jointly with community partners and a transdisciplinary team and uses neurobiological concepts as a “simplification rule” for streamlining behavioral interventions so that they can be used by community clinicians; 3) integrates mobile technology to community interventions at the assessment, the intervention, and the adherence monitoring levels; and 4) tests its interventions at community sites using community clinicians to shorten the way to uptake and sustainability. To maximize our impact, we will work both in settings in which most older and middle-aged people receive care (primary care) and in settings serving persons with special clinical (elder mistreatment) and social needs (poverty). The Center's approach is a clear departure from traditional intervention and services research and can lead to a revolutionary change in how the field thinks about T2 intervention development and deployment in the community. Our Methods Core will provide quality control for the Center's projects, serve as an incubator for innovative approaches to novel design and analytic methods that enhance the information yield of effectiveness data. It also uses big-data to aid the identification of populations in need of novel interventions, provides policy support, and integrates novel mobile technology approaches to community interventions. The Core will also evaluate the Center's productivity and impact on the field and disseminate its methodological advances. We are confident that we can meet the challenges of this work because of our 20 years of working together with stakeholders and community partners in intervention planning and implementation supported by 4 consecutive NIMH-funded Center grants, a large portfolio of independently funded studies, and a strong record of research training and career development of junior investigators.

Alacrity Center摘要 老年人的迅速增加（到2020年，美国预期的73％）和疾病和 残疾使他们的护理复杂化，使该领域的研究成为国家优先事项。我们专注于后期和中期 情绪障碍是因为它们是残疾的主要原因，增加医疗发病率和死亡率， 造成痛苦，并增加护理成本。药物治疗无法满足不超过一半的需求 这些人和大多数非药物疗法是复杂的，可扩展性和触及范围有限。 我们建议将基于部署的行为干预措施的新型模型和 实施，基于神经生物学模型，并通过移动技术增强。相当 而不是专注于可用干预措施的吸收和可持续性，其中许多也是 社区使用的复杂性，我们正在努力简化治疗本身并改善他们的治疗方法 送货。根据我们的模型：1）目标是由消费者，社区合作伙伴和我们的群体确定的群体 团队。 2）与社区合作伙伴和跨学科团队共同开发干预措施，并使用 神经生物学概念是简化行为干预措施的“简化规则”，以便它们可以成为 社区临床医生使用； 3）将移动技术与评估时的社区干预措施相结合， 干预措施以及依从性监测水平； 4）使用 社区临床医生缩短了吸收和可持续性的道路。为了最大化我们的影响，我们将工作 在大多数老年人和中年人获得护理（初级保健）和设置的环境中 服务特殊临床（老年人虐待）和社会需求（贫困）的人。中心的方法 与传统的干预和服务研究明显不同，可以导致革命性的变化 在该领域如何思考T2干预开发和社区部署。 我们的方法核心将为中心的项目提供质量控制，作为创新的孵化器 新型设计和分析方法的方法，可以增强有效性数据的信息产量。它 还使用Big-Data来帮助确定需要新颖干预的人群，提供政策 支持，并将新颖的移动技术方法整合到社区干预措施中。核心也将 评估该中心对现场的生产力和影响，并传播其方法论的进步。 我们有信心，我们可以满足这项工作的挑战，因为我们有20年的合作 利益相关者和社区合作伙伴在干预计划和实施方面，由4 连续的NIMH资助中心补助金，大量的独立研究组合以及强者 初级研究人员的研究培训和职业发展记录。