1/2 Stepped, reward-exposure based therapy vs. PST in late life depression

1/2 阶梯式奖励暴露疗法与 PST 治疗晚年抑郁症的比较

基本信息

批准号：
9251913
负责人：
GEORGE S ALEXOPOULOS
金额：
$ 36万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9251913
关键词：
Age Alternative Therapies Behavior Therapy Behavioral Biological Biology Caring Characteristics Clinical Clinical Trials Collaborations Color Communities Competence Depressed mood Disease Disease remission Doctor of Medicine Doctor of Philosophy Elderly Executive Dysfunction Female Gender Generations Geriatrics Hamilton Rating Scale for Depression Hour Intervention Major Depressive Disorder Medical Mental Depression Mental Health Moods Multicenter Studies Neurobiology Neurosciences Nurses Outcome Participant Patients Persons Pharmacotherapy Physical activity Policies Population Protocols documentation Provider Psychotherapy Quality of life Randomized Recording of previous events Recruitment Activity Reporting Research Resources Rewards Sample Size Science Self Efficacy Services Severities Site Social Workers Structure Techniques Time Training World Health Organization World Health Organization Disability Assessment Schedule aging population base chronic depression community setting comparative efficacy cost data management design disability effective therapy emotion dysregulation evidence base experience geriatric depression improved non-demented novel therapeutics older patient predictive modeling problem solving therapy programs public health relevance response skills social theories therapy development treatment adherence treatment response

项目摘要

DESCRIPTION (provided by applicant): Engage is a novel therapy for late life depression, a disorder that worsens the outcomes of most medical illnesses, promotes disability, increases expense, and complicates medical care by clouding the clinical picture and undermining treatment adherence. Late-life depression has a modest response to pharmacotherapy, and although problem-solving therapy (PST) was found efficacious, it is rarely utilized by community clinicians. Engage targets behavioral domains of late-life depression grounded on neurobiological constructs using behavioral strategies of known efficacy selected for their simplicity. "Reward exposure" is the principal treatment vehicle of Engage. The first 3 sessions consist of direct "reward exposure" but the therapists search for barriers in 3 behavioral domains, i.e. "negativity bias", "apathy", and "emotional dysregulation", and add strategies targeting these domains when needed. Engage uses a structured, stepped-care approach and makes personalization part of the treatment itself. The primary hypothesis of the study is that Engage is non-inferior to problem solving therapy (PST), a treatment with demonstrated efficacy in late life depression. Its secondary hypotheses postulate that Engage requires fewer training hours than PST, is non-inferior to PST in reducing disability and in inducing remission of depression. Exploratory analyses will focus on long-term efficacy of Engage (over 26 and 52 weeks) as well as mechanisms and predictors of its effects. The participants will be 300 (150 from each Center) older (>60 years) non-psychotic, non-demented persons with unipolar major depression who will be randomly assigned to 9 sessions of Engage or PST. We bring to this project two research groups with a history of a successful collaboration in 2 two-center R01 supported psychotherapy studies, complementary expertise in clinical biology, intervention development, clinical trials, and experience in directing multicenter studies. This application responds to two IOM reports, which predict that the workforce in geriatrics will be overwhelmed by the aging population, a problem that will reach cataclysmic proportions when the Affordable Care Programs come into being. Older adults seek services in community settings where the providers of initial care for depression are social workers and nurses without in-depth training in psychotherapies. Engage is designed for such clinicians and, therefore, may have broad scalability (used by many professionals) and reach by offering to many depressed seniors access to effective psychotherapy. The stepped approach to personalization used by Engage may make it applicable to other populations.