Yale Alzheimer Disease Research Center

耶鲁大学阿尔茨海默病研究中心

基本信息

批准号：
9293193
负责人：
STEPHEN M STRITTMATTER
金额：
$ 166.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-15 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9293193
关键词：
Acetylcholine Advisory Committees Alzheimer&apos s Disease Amyloid beta-Protein Autopsy Award Axon Beds Biological Biological Assay Biological Markers Biology Blood Cells Brain Career Mobility Cellular biology Clinic Clinical Clinical Data Clinical Trials Communities Connecticut DNA Data Dementia Development Disease Education and Outreach Emotional Faculty Failure Family Functional disorder Funding Future Genetic Geriatrics Goals Hospitals Image Impaired cognition Knowledge Laboratories Laboratory Research Lead Life Link Lysosomes Mass Spectrum Analysis Medical Students Memory Memory Disorders Mentors Mentorship Methodology Methods Minority Molecular Monitor Mus Nerve Degeneration Neurology Neurons Neuropsychology Neurosciences Nursing Faculty Optical Methods Organelles Pathology Pathway interactions Peptides Pilot Projects Positron-Emission Tomography Presenile Alzheimer Dementia Proteomics Recording of previous events Records Research Research Personnel Research Project Grants Resources Role Serum Signal Transduction Specificity Specimen Synapses Testing Therapeutic Training Translating United States National Institutes of Health Vocational Guidance Whole Blood Work awake brain tissue career career development clinical care cohort data management density exome sequencing experimental study graduate student human subject human tissue induced pluripotent stem cell member multiple reaction monitoring network dysfunction neuroimaging neuropathology neuroproteomics novel outreach proteostasis public health relevance receptor repaired research and development research facility research study sample collection statistics success

项目摘要

DESCRIPTION (provided by applicant): The Yale ADRC seeks to advance our understanding of Alzheimer's disease with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Five Cores (Administrative, Clinical, Data, Biomarker/Pathology and Outreach) and 3 Research Projects (Lysosomes, Post-Synaptic Densities and GABAergic Networks) will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its disruption in Alzheimer's disease triggered by abnormal forms of Amyloid-β peptide. Research Projects will focus on specific neuronal organelles and specific neuronal subtypes perturbed in disease and make use of human tissue analysis and human subject imaging to evaluate mechanistic hypotheses. The Biomarker/Pathology Core will develop novel, sensitive and high-throughput mass spectrometry assays by targeted multiple-reaction monitoring (MRM) to monitor disease mechanisms. A key emphasis will be the translational development of research findings into therapeutic benefit. To support the future strength of Alzheimer's research, the Yale ADRC will strive to advance the careers of Young Investigators through mentorship from a distinguished Internal Advisory Committee, and through Pilot Project awards. In addition to collecting clinical data and biospecimens of brain, CSF, DNA, serum, blood cells and iPSCs for analysis by members of the ADRC research team, the ADRC will support other Yale NIH-funded research studies on related topics and contribute materials to national NIA-sponsored research networks. The Outreach Core will connect with the community to provide greater knowledge regarding Alzheimer's disease and related dementia.

描述（由适用提供）：耶鲁ADRC试图以将实验室发现转化为新型有效临床疗法的目标，以提高我们对阿尔茨海默氏病的理解。五个核心（行政，临床，数据，生物标志物/病理和外展）和3个研究项目（溶酶体，突触后密度和GABA能网络）将共同实现这一目标。我们的统一主题是针对特定神经元的细胞生物学，以及它在异常形式的淀粉样蛋白β肽引发的阿尔茨海默氏病的破坏。研究项目将重点关注特定的神经元细胞器和疾病受干扰的特定神经元亚型，并利用人体组织分析和人类受试者成像来评估机械假设。生物标志物/病理核心将通过靶向的多反应监测（MRM）来监测疾病机制，从而开发新颖，敏感和高通量质谱法案。关键重点是将研究结果转化为治疗益处。为了支持阿尔茨海默氏症研究的未来实力，耶鲁ADRC将努力通过杰出的内部咨询委员会的心态和试点项目奖。除了收集大脑，CSF，DNA，血清，血清，血细胞和IPSC的临床数据以及ADRC研究团队成员分析外，ADRC还将支持其他耶鲁大学NIH资助的有关相关主题的研究，并为国家NIA赞助的国家NIA赞助的研究网络贡献材料。外展核心将与社区联系，以提供有关阿尔茨海默氏病和相关痴呆症的更多知识。