Yale Alzheimer Disease Research Center

耶鲁大学阿尔茨海默病研究中心

• 批准号: 10180851
• 负责人: STEPHEN M STRITTMATTER
• 金额: $ 320.33万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10180851
• 关键词: Address; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Award; Axonal Transport; Back; Behavioral; Biological; Biological Assay; Biological Markers; Blood Cells; Brain; Career Mobility; Caregiver support; Cells; Cellular biology; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Connecticut; Coupled; DNA; Data; Data Collection; Data Set; Dementia; Development; Diagnostic Imaging; Disease; Education and Outreach; Evaluation; Faculty; Family; Fostering; Functional Magnetic Resonance Imaging; Funding; Future; Genome; Genomics; Gerontology; Goals; Heterogeneity; Hospitals; Image; Impaired cognition; Individual; Intention; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Life; Ligands; Lysosomes; Maps; Mass Spectrum Analysis; Measures; Memory Disorders; Mentors; Mentorship; Methodology; Methods; Methylation; Minority; Modification; Molecular; Molecular Analysis; Monitor; Nerve Degeneration; Neurology; Neuronal Dysfunction; Neurons; Neuropsychology; Neurosciences; Organelles; Pathologic; Pathway interactions; Pharmacology; Phase; Play; Population; Positron-Emission Tomography; Proteome; Recording of previous events; Records; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Role; Serum; Signal Transduction; Site; Specimen; Synapses; Testing; Therapeutic; Tracer; Training; Translating; Translations; United States National Institutes of Health; Vocational Guidance; Whole Blood; Work; base; bench to bedside; brain tissue; career; career development; clinical care; cohort; data management; education research; epigenomics; ethnic diversity; family burden; graduate student; human subject; human tissue; induced pluripotent stem cell; kinase inhibitor; member; neuropathology; novel; outreach; programs; recruit; repaired; research and development; research study; sample collection; statistics; success; therapeutic development; transcriptomics

PROJECT SUMMARY: OVERALL YALE ADRC The Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Seven Cores (Administrative, Clinical, Data, Biomarker, Neuropathology, Imaging and Outreach) and a Research Education Component will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its disruption in AD, whether measured by genome/proteome-wide methods in Biofluids, imaged diagnostically, manifested clinically in behavioral attributes, detected pathologically in brain tissue at autopsy or observed in cultures of induced pluripotent stem cells. The participation of the seven Cores will accelerate and optimize the ability of individual Research Projects both within and beyond the Yale ADRC to ask and answer specific pathophysiological questions and to translate knowledge to therapies. The breadth of the Core support for particular projects will allow assessments across the heterogeneity of Alzheimer’s disease. The Yale ADRC expects to extend its track record of facilitating Research Projects focused on specific neuronal organelles and specific neuronal subtypes perturbed in disease while making use of human tissue analysis and human subject imaging to evaluate mechanistic hypotheses. The Biomarker Core will develop novel, sensitive and high-throughput mass spectrometry assays and genomic methylation profiles to monitor disease mechanisms. The Imaging Core will develop, integrate and apply novel PET tracers and functional MRI connectivity maps to subjects of the Clinical Core and multiple separately supported Research Projects. A key emphasis will be the translational development of research findings into therapeutic benefit. To support the future strength of Alzheimer’s research, the Yale ADRC will strive to advance the careers of Young Investigators through mentorship from a distinguished Internal Advisory Committee, and through Development Project awards coupled with an extensive educational program developed by the Research Education Component. In addition to collecting clinical data and biospecimens of brain, CSF, DNA, serum, blood cells and iPSCs for analysis by members of the Yale ADRC research team, the Yale ADRC will support other NIH- funded research studies on related topics and contribute materials to national NIA-sponsored research networks. The Outreach Core will connect with the community to provide greater knowledge regarding Alzheimer’s disease and related dementia.

项目摘要：总体Yale ADRC 耶鲁·阿尔茨海默氏病研究中心（ADRC）试图促进我们对 阿尔茨海默氏病处于细胞生物学水平，最终的目标是将实验室发现转化为 新型有效的临床疗法。七个核心（行政，临床，数据，生物标志物，神经病理学， 成像和外展）以及研究教育部分将共同实现这一目标。我们的 统一主题是针对特定神经元的细胞生物学及其在AD中的破坏，无论是通过 生物流体中的基因组/蛋白质组范围的方法，诊断成像，在临床上表现在行为上 属性，在尸检时在脑组织中在病理上检测到或在诱导多能茎的培养物中观察到 细胞。这七个核心的参与将加速并优化个人研究的能力 耶鲁ADRC内外的项目询问和回答特定的病理生理问题和 将知识转化为疗法。对特定项目的核心支持的广度将允许 跨阿尔茨海默氏病异质性的评估。 耶鲁ADRC希望扩展其促进研究项目的往绩记录 使用人体组织的神经元细胞器和特定的神经元亚型在疾病中扰动 分析和人类主题成像以评估机理假设。生物标志物核心将发展 新颖，敏感和高通量质谱分析和基因组甲基化轮廓以监测 疾病机制。成像芯将发展，整合和应用新颖的宠物示踪剂和功能 MRI连通性图与临床核心和多个单独支持的研究项目的受试者。一个 关键重点将是将研究结果转化为治疗益处的发展。支持 阿尔茨海默氏症研究的未来力量，耶鲁大学ADRC将努力促进年轻的职业 通过杰出的内部咨询委员会的心态调查人员，并通过发展 项目奖与研究教育开发的广泛的教育计划相结合 成分。除了收集大脑，CSF，DNA，血清，血细胞的临床数据和生物测量外 Yale ADRC研究团队成员的IPSC进行分析，耶鲁ADRC将支持其他NIH- 有关相关主题的资助研究，并为国家NIA赞助的研究贡献材料 网络。外展核心将与社区建立联系，以提供有关的更多知识 阿尔茨海默氏病和相关痴呆症。