Northeast Node of the National Drug Abuse Clinical Trials Network

国家药物滥用临床试验网络东北节点

• 批准号: 9274950
• 负责人: Lisa A. Marsch
• 金额: $ 74.84万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274950
• 关键词: Achievement; Adolescent; Adult; Alcohol or Other Drugs use; American; Analgesics; Behavioral; Caring; Chronic; Clinical; Clinical Trials Network; Collaborations; Communities; Community Networks; Comorbidity; Cost effectiveness research; Criminal Justice; Development; Disease; Drug abuse; Drug user; Effectiveness; Evaluation; Funding; Geographic Locations; HIV; HIV risk; Healthcare Systems; Home environment; Hospitals; Individual; Internet; Intervention; Knowledge; Leadership; Maine; Managed Care; Medical; Mental Health; Mental disorders; Modeling; National Clinical Trials Network; National Institute of Drug Abuse; New Hampshire; Operating System; Patients; Persons; Pharmaceutical Preparations; Pharmacology; Policies; Population; Practical trial; Prevention; Primary Health Care; Principal Investigator; Provider; Public Health; Recovery; Research; Research Infrastructure; Research Support; Resources; Risk; Risk Behaviors; Role; Rural; Rural Community; Rural Health; Sample Size; Sampling; Schools; Science; Seminal; Services; Site; Smoker; Substance Use Disorder; Substance abuse problem; System; Technology; Therapeutic; Time; Tranquilizing Agents; Vermont; Veterans; Work; Youth; addiction; adolescent substance use; aged; base; behavioral health; care systems; chronic pain; college; cost; effectiveness trial; evidence base; illicit drug use; implementation research; insight; marijuana use; medical specialties; opioid use disorder; payment; prescription opioid; primary care setting; programs; public health relevance; ranpirnase; research and development; science education; screening; substance abuse treatment; synergism; technology validation; therapy development; tool

 DESCRIPTION: We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 "Center of Excellence" that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectivenes, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth - both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.

 描述：我们建议建立一个新的 NIDA 临床试验网络 (CTN) 节点——横跨新罕布什尔州、佛蒙特州和缅因州农村社区的东北节点。该节点将与几家大型大学合作，以达特茅斯学院为基地。涵盖 400 多个成人和/或青少年一般医疗保健合作伙伴的提供商网络、一系列成瘾专业行为计划以及国家健康管理护理合作伙伴是该节点的理想家园，因为它也是该节点的家园。 NIDA 资助的技术与行为健康中心 (CTBH) 是一个 P30“卓越中心”，利用科学为针对物质使用障碍 (SUD) 的基于技术（网络、移动）的治疗工具的开发、评估和战略实施提供信息）和相关问题（包括 HIV 风险行为和精神合并症）由 Lisa Marsch 博士领导，她也将担任拟议的 CTN 节点的首席研究员，我们的团队通过提高 CTN 节点的质量和速度来引领该领域。专注于 SUD 技术应用和行为健康治疗的科学研究的成就和影响。我们的团队拥有 SUD 干预开发各个阶段的专业知识，包括可行性、可接受性、功效、功效-效果、有效性（包括多站点）。这项工作包括关于 SUD 整合的开创性研究。这项工作对农村卫生保健系统进行了干预。我们对广泛的人群进行了研究，包括长期吸毒者、吸烟者、退伍军人、慢性疼痛患者、艾滋病毒高危人群以及同时患有 SUD 和精神疾病的人，我们的团队在针对青少年的研究方面拥有特殊的专业知识。涵盖青少年的筛查和评估、预防、治疗、康复支持和护理协调，包括针对青少年大麻使用和处方阿片类药物使用障碍的几项研究。该提案的目的是 (1) 扩大 NIDA CTN。向农村地区的新州发起CTN 的东北节点，从而扩大我们与初级保健和其他社区治疗合作伙伴的合作，以确定和实施针对 SUD 的及时且重要的试验，(2) 支持和制定富有成效的研究议程，特别关注集中利用的 CTN 试验基于技术的工具和/或优先关注青年——无论是在东北节点内，还是通过在国家 CTN 社区内发挥领导和咨询作用，以及 (3) 开发和支持基础设施，以增强协同作用并支持知识和知识的双向共享之间的资源CTBH 和 CTN。这些活动将为农村医疗保健系统中与药物使用相关的需求和优先事项以及各种社区系统中基于技术的干预措施的有效性提供重要的科学发现和见解。