Core F: Biostatistics and Bioinformatics Core

核心 F：生物统计学和生物信息学核心

基本信息

批准号：
9322655
负责人：
Robert H Lyles
金额：
$ 20.75万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9322655
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Area Basic Science Behavioral Behavioral Research Bioinformatics Biometry Biostatistics Core Case Report Form Clinical Clinical Research Clinical Trials Collaborations Communities Consult Consultations Data Data Analyses Data Analytics Databases Development Disease Doctor of Philosophy Ensure Evaluation Faculty Fostering Funding Genomics Goals HIV Health Services Accessibility Immunology Immunology procedure Individual Leadership Methodology Methods Pathway interactions Pattern Positioning Attribute Prevention Program Research Project Grants Publications Publishing Recruitment Activity Research Research Design Research Peer Review Research Personnel Science Scientist Secure Services Techniques Time Training Training Support Universities University resources Work biomedical informatics computerized data processing data management database design design disease registry mathematical model medical specialties member metabolomics molecular marker novel prevent skills social spatiotemporal tool training opportunity transmission process virology working group

项目摘要

Project Summary: Biostatistics and Bioinformatics Core (Core F) The overall goal of the Biostatistics and Bioinformatics Core is to ensure high-quality statistical and data management support and training for CFAR investigators in the design, implementation, analysis, and publication stages of HIV/AIDS-related research. In keeping with this purpose, Core F will provide biostatistical and bioinformatics services to investigators, provide access to group and individual training opportunities, and secure linkages between investigators and biostatisticians, who can assist with methodological developments to address non-standard study design and data analytic challenges in basic, clinical, translational, and social/behavioral research. Educational opportunities available to CFAR investigators through Core F will include tutorials, seminars, and specialty training on emerging analytic topics in HIV research. Advanced biostatistics services available will include the development of novel analytic techniques to strengthen HIV/AIDS projects dependent on genomic and metabolomics data, analysis of spatiotemporal patterns of disease and treatment, causal inference, mathematical modeling of transmission dynamics, and the effective evaluation of virologic and immunological assays and utilization of the resulting data. The Core will provide support for the Emory CFAR Scientific Working Groups (SWGs), and maintain effective cross-core collaborations with the Developmental, Clinical Research, Prevention Science, Immunology, and Virology and Molecular Biomarkers Cores through the establishment of liaison biostatisticians. The Core will secure added value to the Emory CFAR as a whole, by enabling and enhancing the scientific rigor of HIV/AIDS research undertaken by CFAR investigators.

项目摘要：生物统计学和生物信息学核心（核心 F）生物统计学和生物信息学核心的总体目标是确保高质量的统计和数据为 CFAR 调查员提供设计、实施、分析和培训方面的管理支持和培训 HIV/AIDS 相关研究的发表阶段。为了实现这一目的，Core F 将提供生物统计为研究人员提供生物信息学服务，提供团体和个人培训机会，以及确保研究人员和生物统计学家之间的联系，他们可以协助方法学的发展解决基础、临床、转化和数据方面的非标准研究设计和数据分析挑战社会/行为研究。通过 Core F 向 CFAR 调查人员提供的教育机会将包括关于艾滋病毒研究中新兴分析主题的教程、研讨会和专业培训。先进的可用的生物统计服务将包括开发新的分析技术以加强艾滋病毒/艾滋病项目依赖于基因组和代谢组学数据，以及时空模式分析疾病与治疗、因果推理、传播动力学的数学模型以及有效的病毒学和免疫学测定的评估以及所得数据的利用。核心将提供支持埃默里 CFAR 科学工作组 (SWG)，并保持有效的跨核心与发展、临床研究、预防科学、免疫学和病毒学的合作通过建立联络生物统计学家来建立分子生物标志物核心。核心将安全添加通过支持和增强艾滋病毒/艾滋病研究的科学严谨性，为埃默里大学 CFAR 带来整体价值由 CFAR 调查员进行。