2/2 Collaboration to Establish the Prevalence and Characteristics of FASD in U.S. Communities: Continuation of the CoFASP Initiative

2/2 合作确定美国社区 FASD 的患病率和特征：CoFASP 计划的延续

• 批准号: 9348578
• 负责人: Philip Alan May
• 金额: $ 35.28万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9348578
• 关键词: 18 year old; Advisory Committees; Affect; Alcohol consumption; Anatomy; Birth; California; Characteristics; Child; Clinical; Collaborations; Collection; Communities; Coordination and Collaboration; Country; Data; Data Analyses; Data Collection; Data Set; Development; Diagnosis; Diagnostic; Diet and Nutrition; Dietary intake; Drug usage; Epidemiology; Face; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Frequencies; Future; General Population; Genetic; Grant; Growth; Health Status; Information Dissemination; Information Systems; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Journals; Knowledge; Mainstreaming; Manuscripts; Methodology; Methods; Morphology; National Institute on Alcohol Abuse and Alcoholism; North Carolina; Participant; Phenotype; Population; Pregnancy; Prevalence; Prevalence Study; Procedures; Protocols documentation; Publications; Publishing; Recruitment Activity; Reproducibility; Research; Research Activity; Research Personnel; Risk; Risk Factors; Role; Sampling; Sampling Studies; Schools; Site; System; Teratogens; TimeLine; Universities; accurate diagnosis; adverse outcome; alcohol epidemiology; base; behavior measurement; case control; comparative genomic hybridization; demographics; disability; disorder control; epidemiologic data; epidemiology study; fetal; meetings; mother nutrition; nutrition; peer; prenatal; social; socioeconomics; study population; systems research; trait

ABSTRACT The Collaboration of Fetal Alcohol Spectrum Disorders Prevalence (CoFASP) initiative was launched by NIAAA in 2010 to establish reasonable, reproducible, and generalizable estimates of the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) within defined regional communities of the USA. With this proposal, the Fetal Alcohol Epidemiology Research (FASER) Team investigators, coordinated from the University of North Carolina, Chapel Hill, will continue to collaborate with investigators from the University of California, San Diego (UCSD) and NIAAA advisors to complete the specific aims of CoFASP. We will collaborate and produce specific products called for in the new RFA AA-16-007. Under continuing specific aims of CoFASP, FASER collaborators will accomplish the following two aims: 1.) Using criteria agreed upon by CoFASP participants 2012-2015, we will complete all sample data, analyses, and co-authored manuscripts on the prevalence and characteristics of FASD and maternal risk factors for FASD. The data come from nine independent samples collected by the FASER Team from five different communities in three different states of the USA. We will deliver all of the data to the UCSD Data Analysis Coordination Unit (DACU) for future analyses and publications. 2.) We will complete: a.) the detailed study samples of maternal nutrition with the Nutrition Data System for Research (NDSR) at FASER sites and b.) the anthropometric study and growth curves of anatomical features essential to the accurate diagnosis of the FASD continuum in children birth - 18 years of age and provide the data to the DACU. 3.) To accomplish new RFA-driven specific aims, we will: a.) collaborate to deliver a timeline and outline of study protocols used to calculate prevalence estimates at each site; b.) complete a co-authored manuscript detailing the final sampling, diagnostic, and robust, analytic methodology for establishing accurate, transparent, site-based prevalence rates in a general population; c.) provide comparisons of how other FASD diagnostic criteria and approaches (e.g. ICD-10, Canadian system, ND-PAE, and clinical judgement) affect diagnosis and prevalence rates of FASD and which approaches mesh most closely with the empirical data generated in the CoFASP studies; d.) clarify the contribution that growth makes to FAS and other FASD; and e.) collaborate for effective completion and dissemination of results through multiple, refereed publications and presentations.

抽象的 胎儿酒精谱系障碍患病率（COFASP）倡议的合作是由 NIAAA在2010年建立对患病率和可再生性和可概括的估计 美国定义的区域社区内胎儿酒精谱系障碍（FASD）的特征。 有了这项建议，胎儿酒精流行病学研究（FASER）团队调查人员协调 北卡罗来纳大学教堂山分校将继续与大学的调查员合作 加利福尼亚州，圣地亚哥（UCSD）和NIAAA顾问完成了COFASP的具体目标。我们将 在新的RFA AA-16-007中协作并生产特定的产品。在持续的特定目标下 Faser合作者将完成以下两个目标：1。）使用标准 COFASP参与者2012 - 2015年，我们将完成所有样本数据，分析和共同撰写的手稿 FASD的FASD和母体风险因素的患病率和特征。数据来自九个 FASER团队从五个不同社区的三个不同州收集的独立样本 美国。我们将把所有数据交付给UCSD数据分析协调单元（DACU） 分析和出版物。 2.）我们将完成：a。）与 FASER站点和B的营养数据系统（NDSR）。）人体测量学研究和生长 解剖特征的曲线对于准确诊断儿童FASD连续体至关重要-18 年龄并向DACU提供数据。 3.）要实现新的RFA驱动的特定目标，我们将： 合作提供时间表和研究协议的概述，用于计算每个 地点; b。）完成一个共同撰写的手稿，详细介绍了最终抽样，诊断和强大的分析 在普通人群中建立准确，透明，基于场地的患病率的方法； c。） 提供其他FASD诊断标准和方法的比较（例如，ICD-10，加拿大系统， ND-PAE和临床判断）影响FASD的诊断和患病率，并且接近网格 与COFASP研究中产生的经验数据最紧密。 d。）阐明增长的贡献 制作FAS和其他FASD；和e。）合作以有效完成和传播结果 通过多个被指导的出版物和演讲。

项目成果

Characteristic physical traits of first-grade children in the United States with fetal alcohol spectrum disorders (FASD) and associated alcohol and drug exposures.

• DOI: 10.1002/ajmg.a.62738
• 发表时间: 2022-07
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART A
• 影响因子: 2
• 作者: May, Philip A.;Hasken, Julie M.;Manning, Melanie A.;Robinson, Luther K.;Abdul-Rahman, Omar;Adam, Margaret P.;Jewett, Tamison;Elliott, Amy J.;Kalberg, Wendy O.;Buckley, David;Hoyme, H. Eugene
• 通讯作者: Hoyme, H. Eugene

Estimating the community prevalence, child traits, and maternal risk factors of fetal alcohol spectrum disorders (FASD) from a random sample of school children.

• DOI: 10.1016/j.drugalcdep.2021.108918
• 发表时间: 2021-10-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: May PA;Hasken JM;Hooper SR;Hedrick DM;Jackson-Newsom J;Mullis CE;Dobyns E;Kalberg WO;Buckley D;Robinson LK;Abdul-Rahman O;Adam MP;Manning MA;Jewett T;Hoyme HE
• 通讯作者: Hoyme HE