Examining the Integrative Effects of Adolescent, Parent, Provider, and Practice Level Factors on Adolescents' HPV Vaccine Uptake across Six Asian American Subgroups

检查青少年、家长、提供者和实践水平因素对六个亚裔美国人亚群体青少年 HPV 疫苗接种的综合影响

• 批准号: 10371334
• 负责人: Lin Zhu
• 金额: $ 8.32万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10371334
• 关键词: 12 year old; 17 year old; 9 year old; Address; Adolescent; Advisory Committees; Affect; Age; Anogenital venereal warts; Asian; Asian Americans; Asian Indian; Awareness; Centers for Disease Control and Prevention (U.S.); Cervix Uteri; Cessation of life; Characteristics; Child; Chinese; Clinic; Clinical; Clinical Research; Complex; Data; Development; Disease; Eligibility Determination; Empirical Research; Equation; Ethnic Origin; Family Practice; Female Adolescents; Filipino; Goals; Gold; Health; Hospitals; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papillomavirus 16; Human papillomavirus 18; Immunization; Individual; Japanese; Knowledge; Koreans; Link; Literature; Logistic Regressions; Malignant Neoplasms; Mediating; Mediator of activation protein; Modeling; National Cancer Institute; Oropharyngeal; Parents; Pediatrics; Persons; President' s Cancer Panel; Process; Provider; Public Health; Race; Recommendation; Reporting; Research; Role; Safety; Sampling; Sampling Studies; Services; Sexually Transmitted Diseases; Subgroup; Surveys; Teenagers; Translating; Vaccinated; Vaccination; Vaccines; aged; base; boys; clinical practice; data to knowledge; disparity reduction; epidemiologic data; evidence base; girls; high risk; high risk population; improved; medical specialties; penis; practice factors; prevent; social; social culture; social determinants; vaccination outcome; vaccine acceptance; 12 year old; 17 year old; 9 year old; Address; Adolescent; Advisory Committees; Affect; Age; Anogenital venereal warts; Asian; Asian Americans; Asian Indian; Awareness; Centers for Disease Control and Prevention (U.S.); Cervix Uteri; Cessation of life; Characteristics; Child; Chinese; Clinic; Clinical; Clinical Research; Complex; Data; Development; Disease; Eligibility Determination; Empirical Research; Equation; Ethnic Origin; Family Practice; Female Adolescents; Filipino; Goals; Gold; Health; Hospitals; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papillomavirus 16; Human papillomavirus 18; Immunization; Individual; Japanese; Knowledge; Koreans; Link; Literature; Logistic Regressions; Malignant Neoplasms; Mediating; Mediator of activation protein; Modeling; National Cancer Institute; Oropharyngeal; Parents; Pediatrics; Persons; President' s Cancer Panel; Process; Provider; Public Health; Race; Recommendation; Reporting; Research; Role; Safety; Sampling; Sampling Studies; Services; Sexually Transmitted Diseases; Subgroup; Surveys; Teenagers; Translating; Vaccinated; Vaccination; Vaccines; aged; base; boys; clinical practice; data to knowledge; disparity reduction; epidemiologic data; evidence base; girls; high risk; high risk population; improved; medical specialties; penis; practice factors; prevent; social; social culture; social determinants; vaccination outcome; vaccine acceptance

PROJECT SUMMARY Human papillomavirus (HPV) is the most common form of sexually transmitted infection in the US, with approximately 79 million US individuals infected with HPV. The Advisory Committee on Immunization Practices (ACIP) recommends vaccine initiation between 11–12 years old, and it can be initiated as young as 9 years old. However, less than half of 13- to 17-year-old girls and less than one-third boys were fully vaccinated against HPV, much lower than the80% goal of Healthy People 2030. Significant barriers to HPV vaccination have been identified in 1) missed clinical opportunities due to provider and practice-related barriers, 2) low parental awareness, and 3) limited access to HPV vaccination services due to sociocultural and financial barriers. Asian Americans are disproportionally affected by HPV and HPV related conditions. Despite public health efforts, HPV vaccination rates were suboptimal in Asian American adolescents. Regional data showed low awareness of HPV vaccine and low vaccination rates in Chinese, Filipino, Japanese, Asian Indian, Korean, and Vietnamese subgroups. However, literature of the multilevel social determinants of HPV vaccine in Asian Americans is limited. Identifying high-risk groups and the multilevel mechanisms of HPV vaccine uptake are crucial in reducing disparities and increasing HPV vaccination rates in Asian American adolescents. This study will be the first study to use a nationally representative sample to examine the integrative effects of adolescent, parent, provider, and practice level factors in six Asian American subgroups. The proposed study will leverage the existing data from the 2010–2019 National Immunization Survey-Teen (NIS- Teen), the gold standard of US vaccination data. The study sample will include 6,019 boys and girls aged 13– 17 of Chinese (1,613), Filipino (1,383), Japanese (834), Indian (800), Korean (786), and Vietnamese (603) ethnicity. The specific aims are, Aim 1: to examine the integrative effects of adolescent, parent, provider, and practice level factors in their association with adolescent's HPV vaccine initiation and completion among six Asian American subgroups. Aim 2: to investigate the parent-reported reasons for delay or refusal of HPV vaccine for adolescents across six Asian American subgroups. Each specific aim addresses a unique research question that links practice/provider characteristics with adolescents/parent level factors, and together provide a comprehensive understanding of the social mechanisms of HPV vaccine uptake in Asian adolescents. Findings of this proposed study will provide subgroup-specific epidemiological data, guide the improvement of clinical practices, and inform the development of evidence-based strategies to reduce missed opportunities and improve adolescent vaccination in Asian American adolescents.

项目摘要 人乳头瘤病毒（HPV）是美国最常见的性传播感染形式 大约7900万美国人感染了HPV。免疫实践咨询委员会 （ACIP）建议在11-12岁之间采取疫苗倡议，并且可以启动至9岁的年龄。 但是，只有不到13至17岁的女孩和不到三分之一的男孩完全接种疫苗 HPV，远低于2030年健康人的80％目标。 在1）由于提供者和练习相关的障碍而错过的临床机会，2）父母低的临床机会 意识和3）由于社会文化和财务障碍而导致的HPV疫苗接种服务有限。 亚裔美国人受HPV和HPV相关条件的影响不成比例。尽管公开 在亚裔美国青少年中，健康努力，HPV疫苗接种率是次优的。显示的区域数据 中国，菲律宾，日本，亚洲印第安人，韩国人的HPV疫苗和低疫苗率的认识较低 和越南亚组。但是，亚洲HPV疫苗的多层次社会决定者的文献 美国人有限。识别高风险组和HPV疫苗摄取的多级机制是 在降低亚裔美国青少年的差异和HPV疫苗接种率的关键中。 这项研究将是第一项使用全国代表性样本检查综合样本的研究 青少年，父母，提供者和实践水平因素在六个亚裔美国亚组中的影响。 拟议的研究将利用2010 - 2019年全国免疫调查的现有数据（NIS-- 青少年），美国疫苗接种数据的黄金标准。研究样本将包括6,019名13岁的男孩和女孩 中国人（1,613），菲律宾（1,383），日语（834），印度（800），韩国人（786）和越南语（603）的17 种族。具体目的是 目标1：检查青少年，父母，提供者和实践水平因素的综合效应 他们与青少年的HPV疫苗倡议和六个亚裔美国人之间的联系 亚组。 目标2：调查父母报告的延迟或拒绝的原因 在六个亚裔美国亚洲群体中。 每个特定目的都解决了一个独特的研究问题，将实践/提供者特征与 青少年/父母级别的因素，并共同提供了对社会的全面理解 亚洲青少年中HPV疫苗摄取的机制。 发现 的 这 建议的 学习 将要 提供 亚组特异性流行病学数据，指导临床实践的改善，并告知 制定基于循证的策略，以减少错失机会并改善青少年疫苗接种 在亚裔美国青少年中。