Prevalence and Traits of FASD in the US Population: Evidence from Schools

美国人口中 FASD 的患病率和特征：来自学校的证据

• 批准号: 8010704
• 负责人: Philip Alan May
• 金额: $ 24.59万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8010704
• 关键词: Affect; American; Characteristics; Child; Clinical; Collaborations; Collection; Country; County; Data; Data Analyses; Diagnosis; Diagnostic Procedure; Epidemiologic Methods; Etiology; Face; Fetal Alcohol Spectrum Disorder; Funding; Future; Gene Deletion; General Population; Genetic; Growth; Mainstreaming; Measures; Methods; Morphology; Mothers; Nature; Pilot Projects; Population; Positioning Attribute; Prevalence; Prevalence Study; Preventive Intervention; Procedures; Pseudonym; Public Health; Research; Research Personnel; Risk Factors; Sampling; Schools; Screening procedure; Sioux Falls; Structure; Syndrome; Techniques; Testing; Time; Woman; case control; cohort; comparative genomic hybridization; experience; falls; innovation; population based; public health relevance; trait

DESCRIPTION (provided by applicant): Background/Project Summary: Accurate assessments of the prevalence and population-based characteristics of fetal alcohol spectrum disorders (FASD) are sorely needed and long overdue for the U.S. mainstream population. The true extent, nature, and impact of FASD in the general population of the U.S., and in our schools, are currently unclear and/or unknown, although a recent estimate has placed the prevalence of FASD at 2 to 5%. Through screening, testing, and highly-structured interdisciplinary, lOM-recommended diagnostic procedures in 1st grade classes of three populations, we propose to: 1) assess the prevalence of FASD in two cohorts each within three specific 1st grade populations in the U.S. via two different applications of case control and random sampling methods; 2) define the exact characteristics of a) physical growth and morphology and b) neurodevelopmental characteristics U.S. children with and without FASD; 3) apply array comparative genomic hybridization (aCGH) techniques, in a nested study, to assess any major genetic factors (e.g. gene deletion syndromes) that may affect facial dysmorphia in cases of severe FASD (FAS or PFAS); 4) define specific maternal risk factors among mainstream American women for various levels of FASD; and 5) coordinate all data content, collection, formatting, and procedures with the Data Analysis Coordination Component (DACC) of the Collaboration of FASD Prevalence (CoFASP), and provide all data collected to the DACC of this NIAAA-funded initiative. Research will take place in: Great Falls, MT; Sioux Falls, SD; and ABC County, NC [pseudonym]. Three pilot studies have been carried out in Great Falls, and FASD has been estimated there at 1 to 2.5% of 1st grade children, a rate substantially higher than current estimates for the U.S. We are in a truly unique position at this time. As our epidemiologic methods and procedures have matured, the directions for innovation within future studies of U.S. populations are clear. Our experienced team of clinical researchers is cohesive, interdisciplinary, and expert, with 12 years experience in similar studies in the U.S. and foreign countries. This is an opportune time for this population-based study of the prevalence and characteristics of FASD in mainstream U.S. populations where FASD may be a substantially large, but underreported, public health problem. PUBLIC HEALTH RELEVANCE: The prevalence and characteristics of fetal alcohol spectrum disorders (FASD) in the mainstream U.S. population are not known; recent estimates hold that FASD may affect 2 to 5% of all children. Innovative, active case ascertainment research on FASD in 1st grade children (and their mothers) of 3 representative U.S. populations will produce accurate measures of the magnitude, characteristics, and specific contextual etiology of FASD in mainstream populations. A better understanding of the public health and clinical impact of FASD in the general population will guide the way to better diagnosis, intervention, and prevention.

描述（由申请人提供）： 背景/项目摘要：迫切需要对胎儿酒精谱系障碍（FASD）的患病率和基于人群的特征的准确评估，对于美国主流人群而言是长期的。 FASD在美国以及我们学校中的真实程度，性质和影响目前尚不清楚和/或未知，尽管最近的估计使FASD的流行率为2％至5％。通过筛选，测试和高度结构的跨学科，LOM启用的诊断程序在三个人群的一年级类别中，我们建议：1）评估美国在美国三个特定的1年级人群中通过案例控制和随机采样方法的两种不同的一年级人群中的两个同类群体中的FASD流行； 2）定义a）身体生长和形态的确切特征和b）神经发育特征美国有或没有FASD的儿童； 3）在一项嵌套研究中，应用阵列比较基因组杂交（ACGH）技术来评估可能影响严重FASD（FAS或PFAS）的任何主要遗传因素（例如基因缺失综合征）； 4）在各种水平的FASD中定义主流妇女中的特定母亲危险因素； 5）将所有数据内容，收集，格式化和程序与FASD Pristrience（COFASP）协作的数据分析协调组件（DACC）进行协调，并将收集的所有数据提供给该NIAAA资助的计划的DACC。研究将在：大瀑布市，MT；苏福尔斯，SD；和北卡罗来纳州ABC县[化名]。大瀑布（Great Falls）进行了三项试点研究，FASD估计为1至2.5％的一年级儿童，这一比率大大高于美国目前的估计，我们目前处于真正独特的位置。随着我们的流行病学方法和程序已经成熟，在未来对美国人口的研究中的创新方向是显而易见的。我们经验丰富的临床研究人员团队具有凝聚力，跨学科和专家，在美国和国外的类似研究中拥有12年的经验。这是对这项基于人群的研究的适当时机，该研究是对美国主流人口中FASD的流行率和特征的研究，因为FASD可能是一个大大但不足的公共卫生问题。 公共卫生相关性：美国主流人口中胎儿酒精谱系（FASD）的患病率和特征尚不清楚；最近的估计认为FASD可能影响所有儿童的2至5％。对3个代表人群的一年级儿童（及其母亲）对FASD的创新，主动案例确定研究将对主流人群中FASD的大小，特征和特定情境病因进行准确的衡量。更好地了解FASD对普通群体的公共卫生和临床影响将指导更好的诊断，干预和预防。