Development and Control of Pulmonary alveolar Stability

肺泡稳定性的发展和控制

基本信息

批准号：
8207974
负责人：
Samuel Hawgood
金额：
$ 182.84万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8207974
关键词：
Acute Acute Lung Injury Address Adherent Culture Adult Allergens Alveolar Alveolar Cell Alveolar Process Alveolar wall Alveolus Animals Antibodies Architecture Attention Back Biochemical Biochemistry Biological Models Biological Process Biology Breathing Budgets Carbon Dioxide Carcinoembryonic Antigen Cell Adhesion Molecules Cell Differentiation process Cell Lineage Cell physiology Cells Cellular biology Childhood Chronic Chronic lung disease Collaborations Communication Consultations Cost Savings Cultured Cells Cyclic AMP Data Data Set Development Developmental Biology Discipline Disease Distal Doctor of Medicine Doctor of Philosophy Drug Formulations Electrons Epithelial Epithelial Cells Equipment Equipment and Supplies Exposure to Faculty Familiarity Fetal Lung Fibrosis Funding Gases Gene Expression Gene Targeting Genes Genetic Genetic Techniques Genome Genomics Glucocorticoids Goals Growth Growth Factor Health Homeostasis Hormones Host Defense Host Defense Mechanism Housing Human Human Resources Image Analysis Immune Immune system Immunity Individual Infection Infectious Agent Inflammation Inflammatory Injury Institutes Intestinal Neoplasms Intracellular Signaling Proteins Investigation Joints Laboratories Lead Life Light Liquid substance Lung Lung diseases Maintenance Maps Measurement Membrane Metabolism Methods Microscopy Molecular Molecular Biology Molecular Structure Molecular and Cellular Biology Mucous Membrane Mus Natural regeneration Oxygen Peer Review Pennsylvania Personnel Management Phenotype Physiological Physiology Plastics Positioning Attribute Prevention Principal Investigator Process Production Protein Family Proteins Publications Pulmonary Gas Exchange Pulmonary Surfactant-Associated Protein D Pulmonary Surfactants Quality Control Rattus Recording of previous events Regulation Research Research Personnel Research Project Grants Resources Respiratory System Respiratory Tract Infections Respiratory tract structure Rodent Role Schools Science Series Serum-Free Culture Media Services Specialist Stable Populations Stimulus Stress Structure Structure of parenchyma of lung Structure of respiratory epithelium Surface System Techniques Tenascin Testing Time Tissues Transcriptional Regulation Transgenes Transgenic Mice Transgenic Organisms Tumor Markers Type II Epithelial Receptor Cell Undifferentiated Universities Ursidae Family Work alveolar epithelium base cost cost effective disorder control editorial environmental change environmental particulate experience fetal genetic manipulation hormone regulation implementation research improved in vitro Model infancy innate immune function interest lung development lung injury lung repair meetings member microorganism mouse model multidisciplinary novel novel strategies pediatric department pollutant programs protein structure function repaired research study respiratory respiratory distress syndrome response surfactant

项目摘要

DESCRIPTION (provided by applicant): This application proposes to continue multidisciplinary studies of development, control and disorders of the pulmonary parenchyma. The objectives of the proposal are to examine some of the mechanisms involved in the formation and stabilization of the pulmonary parenchyma during development and post-natal life, and in states of health and disease. By stabilization we mean the integrated physiochemical and biological processes that develop and maintain alveolar architecture in an optimal state for pulmonary gas exchange. As in our past studies we emphasize investigations of alveolar epithelial development, functions of the lung surfactant system, and alveolar disease processes leading to infection and inflammation. The broad goals of the three inter-related projects proposed are: Project 1: Structure and function of surfactant proteins. To study the relationship between the structure of the surfactant proteins, specifically SP-D, and their functions in regulating the immune milieu of the alveolus. Project 2: Expression and role of CEACAM6 in the alveolus. To investigate the role of carcinoembryonic antigen-6 in alveolar innate immune defense, surfactant function, and epithelial response to acute lung injury. Project 3: Alveolar epithelial cell fates: mapping and regulation. To study alveolar epithelial cell lineages during development and regeneration and to elucidate novel regulatory molecules important to the process of alveolar epithelial differentiation. The overall purpose of these studies is to deepen our understanding of the processes underlying lung parenchymal stability and to contribute to new concepts and treatments for lung diseases associated with disorders of alveolar stability, growth, maturation, and repair after injury.

描述（由申请人提供）：本申请建议继续对肺实质的发育、控制和疾病进行多学科研究。该提案的目的是研究发育和产后生活以及健康和疾病状态下肺实质形成和稳定的一些机制。通过稳定，我们指的是综合的生理化学和生物过程，其发展和维持肺泡结构处于肺部气体交换的最佳状态。与我们过去的研究一样，我们强调对肺泡上皮发育、肺表面活性物质系统的功能以及导致感染和炎症的肺泡疾病过程的研究。拟议的三个相互关联的项目的总体目标是：项目1：表面活性蛋白的结构和功能。研究表面活性蛋白（特别是 SP-D）的结构与其调节肺泡免疫环境的功能之间的关系。项目 2：CEACAM6 在肺泡中的表达和作用。探讨癌胚抗原 6 在肺泡先天免疫防御、表面活性剂功能和急性肺损伤上皮反应中的作用。项目 3：肺泡上皮细胞命运：绘图和调节。研究发育和再生过程中的肺泡上皮细胞谱系，并阐明对肺泡上皮分化过程重要的新型调节分子。这些研究的总体目的是加深我们对肺实质稳定性基础过程的理解，并为与肺泡稳定性、生长、成熟和损伤后修复相关的肺部疾病提供新的概念和治疗方法。