STRUCTURE AND FUNCTION OF SURFACTANT APOPROTEINS

表面活性剂脱蛋白的结构和功能

• 批准号: 8054533
• 负责人: Samuel Hawgood
• 金额: $ 33.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8054533
• 关键词: Affect; Alveolar; Alveolar Macrophages; Amino Acids; Antigen Presentation; Antigen-Presenting Cells; Antigens; Apoproteins; Area; B-Lymphocytes; Back; Binding; Biochemical Genetics; Body Surface; CD8-Positive T-Lymphocytes; Cell Communication; Cell Surface Receptors; Cell surface; Cells; Collagen; Cytolysis; Dendritic Cells; Development; Endocytosis; Endosomes; Epithelial Cells; Epithelium; Exhibits; Exposure to; Genetic Variation; Grant; Head; Hemagglutinin; Human; Human Genome; Humoral Immunities; Immune response; Immune system; In Vitro; Infection; Inflammation; Influenza; Influenza A virus; Interferon Type I; Laboratories; Lectin; Lung; Membrane Glycoproteins; Modeling; Mus; N-terminal; Positioning Attribute; Proteins; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; Recovery; Regulation; Research Design; Research Personnel; Resistance; Respiratory System; Respiratory tract structure; Role; Source; Structure; Surface; T cell response; T-Lymphocyte; Variant; Viral; Virus; Virus Diseases; base; chemokine; cytokine; cytotoxic; in vivo; innovation; interest; killings; meetings; microorganism; mouse model; pathogen; programs; protein structure; respiratory; response; surfactant; uptake; vaccination strategy

This proposal studies a surfactant-associated protein (SP-D) involved in protecting mucosal surfaces from infection and inflammation. We will study how the structure of the protein is related to function and how common variations in the human genome affect the immuno-modulatory functions of SP-D. The results may relate to the development of new therapies including new vaccination strategies. PHS 398/2590 (Rev. 06/09) Page 63 Continuation Format Page

该提案研究了一种参与保护粘膜的表面活性剂相关蛋白（SP-D） 表面免受感染和炎症的影响。我们将研究蛋白质的结构如何与功能相关 以及人类基因组中的常见变异如何影响 SP-D 的免疫调节功能。这 结果可能与新疗法的开发有关，包括新的疫苗接种策略。 PHS 398/2590 (Rev. 06/09) 第 63 页 继续格式页