Washington Women's Interagency HIV/AIDS Study

华盛顿妇女机构间艾滋病毒/艾滋病研究

基本信息

批准号：
9197945
负责人：
SEBLE G KASSAYE
金额：
$ 296.41万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-08-01 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9197945
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Adherence Aging Area Blood Vessels Budgets Cellular Phone Clinical Collaborations Communities Community Health Comorbidity Cost of Illness Country Data Data Quality Databases Development Disease Outcome Disease Progression Disease model District of Columbia Early Diagnosis Elements Enrollment Epidemic Epidemiology Epigenetic Process Ethical Issues Evaluation Fostering Functional Magnetic Resonance Imaging Functional disorder Funding Generations Genetic screening method Goals Grant HIV HIV Infections HIV risk HIV-1 HIV-associated neurocognitive disorder HIV/HCV Health Health behavior Hepatitis C High Prevalence Highly Active Antiretroviral Therapy Immune response Immunity Individual Infection Intervention Investigation Investments Laboratories Leadership Liver Fibrosis Liver diseases Malignant Neoplasms Malignant neoplasm of liver Measurement Menopausal Status Menopause Mental Depression Methods Microvascular Dysfunction Modeling Morbidity - disease rate National Institute of Allergy and Infectious Disease Neurocognition Neurocognitive Neurocognitive Deficit Organ Outcome Plasma Play Positioning Attribute Predisposition Principal Investigator Prospective Studies Protein Glycosylation Protocols documentation Public Health Recruitment Activity Research Research Infrastructure Research Personnel Research Proposals Risk Risk Behaviors Role Signal Transduction Site Specimen Techniques Technology Telephone Translating United States United States National Institutes of Health Vagina Viral Load result Washington Woman Women Status Women’s Interagency HIV Study Work age effect aging population base cohort data acquisition design effective therapy effectiveness research experience improved innovation interpersonal therapy men metropolitan mortality novel older women prevent protocol development psychosocial public health relevance repository reproductive tract therapeutic development therapy development treatment adherence uptake

项目摘要

DESCRIPTION (provided by applicant): Since 1993, the Washington Metropolitan WIHS (WMW) Consortium has enrolled and retained a representative community cohort of HIV-infected and uninfected women with the purpose of supporting NIAID in understanding the current epidemiology of HIV, risk behaviors, disease progression, treatment uptake and outcomes, and related co-morbidities. The early cohort of infected women is aging, and the effects of age and menopausal status on disease outcomes and co-morbidities is yet to be elucidated. The WMW has joined with centers around the country and with sites across metropolitan Washington, DC to address these issues. This is particularly pertinent as Washington, DC has the highest prevalence of HIV of any urban center in the U.S. and the WMW has enrolled and retained a cohort that represents women both ethnically and psychosocially. The WMW has successfully participated in all elements of the WIHS protocol and has actively supported the infrastructure of the national WIHS. WMW investigators have participated in all of the major WIHS scientific initiatives. Additionally, with its rich data baseand local and national specimen repository, the WMW has supported local and national initiatives designed to understand the pathophysiology underlying co-morbidities. The WMW proposes to continue this work and to expand its research portfolio by continuing its strong collaborative relationship with the national WIHS in the area of protocol development, implementation, sub study participation, and identification of new initiatives. Additionally, for the next cycle of funing we have proposed new initiatives that include a telephone-based intervention for depression that will positively impact adherence and health behaviors with the goal of reducing community viral load. This intervention can easily be implemented in the larger DC community. We are expanding our local initiatives on HIV and HCV associated liver disease by engaging a team of researchers in exploring the host response, epigenetic factors, and protein glycosylation in liver disease and cancer. We will also continue and expand our investigations in organ specific morbidities associated with long-term survival in an aging population with the goal of reducing or preventing morbidity in the areas of vascular health, neurocognitive decline, and the vaginal immunologic response in aging. We will accomplish this by engaging with national and local investigators with proven expertise in these areas to further leverage the NIH investment in this important cohort of women. This will allow us to better define the status of women with HIV and bring to fruition the goals of an AIDS free generation and effective and sustainable treatment for those already infected.

描述（由申请人提供）：自 1993 年以来，华盛顿大都会 WIHS (WMW) 联盟已招募并保留了具有代表性的 HIV 感染和未感染女性社区队列，目的是支持 NIAID 了解当前的 HIV 流行病学、危险行为、疾病进展、治疗的接受和结果以及相关的合并症。早期感染女性群体正在老龄化，年龄和更年期状况对疾病结果和合并症的影响尚未阐明。 WMW 已与全国各地的中心以及华盛顿特区大都市的多个站点合作解决这些问题。这一点尤其重要，因为华盛顿特区的艾滋病毒患病率是美国所有城市中心中最高的，而且 WMW 已经招募并保留了一批在种族和社会心理上都代表女性的群体。 WMW 已成功参与 WIHS 协议的所有要素，并积极支持国家 WIHS 的基础设施。 WMW 研究人员参与了 WIHS 的所有主要科学举措。此外，凭借其丰富的数据库以及地方和国家样本库，WMW 支持地方和国家旨在了解共病病理生理学的举措。 WMW 建议继续开展这项工作，并通过继续与国家 WIHS 在方案制定、实施、子研究参与和新举措识别等领域的强有力的合作关系来扩大其研究组合。此外，对于下一个资助周期，我们提出了新的举措，其中包括基于电话的抑郁症干预措施，这将对依从性和健康行为产生积极影响，以减少社区病毒载量。这种干预措施可以很容易地在更大的特区社区实施。我们正在通过聘请研究人员团队探索肝脏疾病和癌症中的宿主反应、表观遗传因素和蛋白质糖基化，扩大我们在艾滋病毒和丙型肝炎相关肝脏疾病方面的本地举措。我们还将继续并扩大对与老龄化人口长期生存相关的器官特异性发病率的研究，目标是减少或预防老龄化过程中血管健康、神经认知衰退和阴道免疫反应等领域的发病率。我们将通过与在这些领域拥有成熟专业知识的国家和地方研究人员合作来实现这一目标，以进一步利用 NIH 对这一重要女性群体的投资。这将使我们能够更好地确定感染艾滋病毒的妇女的地位，并实现无艾滋病一代和对已感染者进行有效和可持续治疗的目标。