Washington Women's Interagency HIV/AIDS Study

华盛顿妇女机构间艾滋病毒/艾滋病研究

• 批准号: 9197945
• 负责人: SEBLE G KASSAYE
• 金额: $ 296.41万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9197945
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Aging; Area; Blood Vessels; Budgets; Cellular Phone; Clinical; Collaborations; Communities; Community Health; Comorbidity; Cost of Illness; Country; Data; Data Quality; Databases; Development; Disease Outcome; Disease Progression; Disease model; District of Columbia; Early Diagnosis; Elements; Enrollment; Epidemic; Epidemiology; Epigenetic Process; Ethical Issues; Evaluation; Fostering; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Generations; Genetic screening method; Goals; Grant; HIV; HIV Infections; HIV risk; HIV-1; HIV-associated neurocognitive disorder; HIV/HCV; Health; Health behavior; Hepatitis C; High Prevalence; Highly Active Antiretroviral Therapy; Immune response; Immunity; Individual; Infection; Intervention; Investigation; Investments; Laboratories; Leadership; Liver Fibrosis; Liver diseases; Malignant Neoplasms; Malignant neoplasm of liver; Measurement; Menopausal Status; Menopause; Mental Depression; Methods; Microvascular Dysfunction; Modeling; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; Neurocognition; Neurocognitive; Neurocognitive Deficit; Organ; Outcome; Plasma; Play; Positioning Attribute; Predisposition; Principal Investigator; Prospective Studies; Protein Glycosylation; Protocols documentation; Public Health; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Proposals; Risk; Risk Behaviors; Role; Signal Transduction; Site; Specimen; Techniques; Technology; Telephone; Translating; United States; United States National Institutes of Health; Vagina; Viral Load result; Washington; Woman; Women Status; Women’s Interagency HIV Study; Work; age effect; aging population; base; cohort; data acquisition; design; effective therapy; effectiveness research; experience; improved; innovation; interpersonal therapy; men; metropolitan; mortality; novel; older women; prevent; protocol development; psychosocial; public health relevance; repository; reproductive tract; therapeutic development; therapy development; treatment adherence; uptake

DESCRIPTION (provided by applicant): Since 1993, the Washington Metropolitan WIHS (WMW) Consortium has enrolled and retained a representative community cohort of HIV-infected and uninfected women with the purpose of supporting NIAID in understanding the current epidemiology of HIV, risk behaviors, disease progression, treatment uptake and outcomes, and related co-morbidities. The early cohort of infected women is aging, and the effects of age and menopausal status on disease outcomes and co-morbidities is yet to be elucidated. The WMW has joined with centers around the country and with sites across metropolitan Washington, DC to address these issues. This is particularly pertinent as Washington, DC has the highest prevalence of HIV of any urban center in the U.S. and the WMW has enrolled and retained a cohort that represents women both ethnically and psychosocially. The WMW has successfully participated in all elements of the WIHS protocol and has actively supported the infrastructure of the national WIHS. WMW investigators have participated in all of the major WIHS scientific initiatives. Additionally, with its rich data baseand local and national specimen repository, the WMW has supported local and national initiatives designed to understand the pathophysiology underlying co-morbidities. The WMW proposes to continue this work and to expand its research portfolio by continuing its strong collaborative relationship with the national WIHS in the area of protocol development, implementation, sub study participation, and identification of new initiatives. Additionally, for the next cycle of funing we have proposed new initiatives that include a telephone-based intervention for depression that will positively impact adherence and health behaviors with the goal of reducing community viral load. This intervention can easily be implemented in the larger DC community. We are expanding our local initiatives on HIV and HCV associated liver disease by engaging a team of researchers in exploring the host response, epigenetic factors, and protein glycosylation in liver disease and cancer. We will also continue and expand our investigations in organ specific morbidities associated with long-term survival in an aging population with the goal of reducing or preventing morbidity in the areas of vascular health, neurocognitive decline, and the vaginal immunologic response in aging. We will accomplish this by engaging with national and local investigators with proven expertise in these areas to further leverage the NIH investment in this important cohort of women. This will allow us to better define the status of women with HIV and bring to fruition the goals of an AIDS free generation and effective and sustainable treatment for those already infected.

描述（由申请人提供）：自1993年以来，华盛顿大都会WIHS（WMW）联盟已加入并保留了由HIV感染和未感染的HIV感染和未感染的妇女组成的，目的是支持NIAID，以了解HIV的HIV，当前的HIV，危险行为，疾病行为，疾病进展，治疗，侵略性，抗癌和相关性，以及相关性，以及相关性。感染妇女的早期队列是衰老，年龄和更年期地位对疾病结局和合并症的影响尚待阐明。 WMW已与全国各地的中心以及华盛顿大都会大都会的遗址一起加入，以解决这些问题。这与华盛顿，华盛顿特区的艾滋病毒患病率最高，在美国任何城市中心的艾滋病毒率最高，而WMW已经入学并保留了一个同类妇女，代表妇女在种族和心理上。 WMW已成功地参与了WIHS协议的所有要素，并积极支持国家公民银行的基础设施。 WMW调查人员已参加了所有主要的WIHS科学计划。此外，WMW凭借其丰富的本地和国家标本存储库，支持了本地和国家倡议，旨在了解病理生理的合并症。 WMW提议继续这项工作，并通过在协议开发，实施，子研究参与和确定新倡议的领域与国家公民银行的牢固合作关系来扩大其研究组合。此外，在下一个娱乐周期中，我们提出了新的举措，其中包括基于电话的抑郁症干预措施，该干预将对依从性和健康行为产生积极影响，目的是减少社区病毒负荷。可以在较大的DC社区中轻松实施此干预措施。我们通过与一群研究人员参与探索宿主反应，表观遗传因素和蛋白质糖基在肝脏疾病和癌症中的相关肝脏疾病的局部倡议。我们还将继续并扩大我们在老龄化人群中与长期生存相关的器官特异性病毒的调查，目的是降低或预防血管健康，神经认知下降以及衰老的阴道免疫反应的领域的发病率。我们将通过与国家和地方调查员互动在这些领域具有可靠专业知识的国家和地方调查员来实现这一目标，以进一步利用对这一重要妇女队列的NIH投资。这将使我们能够更好地定义患有艾滋病毒的妇女的地位，并实现自由艾滋病一代的目标，并为已经被感染的人提供有效和可持续的待遇。