Signal Processing And Instrumentation Section

信号处理和仪器部分

• 批准号: 9344079
• 负责人: THOMAS J POHIDA
• 金额: $ 135.62万
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9344079
• 关键词: Ablation; Adult; Anesthesiology; Antineoplastic Agents; Atomic Force Microscopy; Auditory; Automation; Baclofen; Bacteriorhodopsins; Behavior; Behavioral; Biological; Biological Assay; Biological Preservation; Biological Process; Biomedical Research; Bioreactors; Blood Volume; Brain; Bronchial Tree; Cardiomyopathies; Cells; Cellular Membrane; Cellular Phone; Cervix Diseases; Chemicals; Child; Chromatin Fiber; Classification; Clinic; Clinical; Clinical Research; Collaborations; Collection; Color Visions; Communication; Communication impairment; Computers; Custom; DNA; Detection; Development; Devices; Diagnosis; Diet; Disease; Dissection; Documentation; Double-Blind Method; Drosophila genus; Electron Spin Resonance Spectroscopy; Electronics; Endoscopes; Endoscopy; Engineering; Environment; Evaluation; Evoked Potentials; Fetal Monitoring; Fluorescence; Fluorescence Microscopy; Fostering; Functional Magnetic Resonance Imaging; Gel; Generations; Genes; Genetic; Genomics; HIV-1; Health; Hematoma; Histopathology; Home environment; Housing; Human; Human Papillomavirus; Hydrogels; Image; Imaging technology; Incubators; Institutes; Intramural Research Program; Knowledge; Laboratories; Laboratory Research; Lasers; Learning; Life; Light; Lighting; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mechanics; Medical center; Methodology; Methods; Microarray Analysis; Microdissection; Microfabrication; Microfluidics; Microscopy; Molds; Molecular Analysis; Monitor; Monkeys; Morphologic artifacts; Motion; Motor; Mus; Muscle Tension; Mutation; N.I.H. Research Support; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Drug Abuse; National Institute of Environmental Health Sciences; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; National Institute on Deafness and Other Communication Disorders; Near-Infrared Spectroscopy; Neurosciences; Obesity; Optical Coherence Tomography; Optics; Oxygen; Pain; Pathology; Perfusion; Pharmaceutical Preparations; Pharmacodynamics; Phase; Phenotype; Pilot Projects; Placebo Control; Positioning Attribute; Positron; Principal Investigator; Printing; Process; Production; Prostate; Prostatectomy; Protein Microchips; Proteomics; Psychological Stress; Radiochemistry; Radioisotopes; Randomized; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Retinal; Robotics; Rodent; Saliva; Scanning; Science; Scientist; Sensory; Signal Transduction; Sjogren' s Syndrome; Skin; Software Engineering; Specimen; Spectrometry; Spinal; Staging; Stimulus; Subcellular structure; System; Systems Analysis; Systems Biology; Techniques; Technology; Testing; Time; Tissue Fixation; Tissue Microarray; Tissues; Training; Traumatic Brain Injury; Ultrasonography; United States National Institutes of Health; Validation; Vision; Visual; Wireless Technology; abeta oligomer; analog; analytical ultracentrifugation; animal imaging; anxious; base; behavior measurement; bioimaging; brain tissue; cDNA Arrays; cancer imaging; cancer surgery; cancer therapy; capsule; chromosome microdissection; collaborative environment; data acquisition; design; detector; digital; driving behavior; drug efficacy; electric field; engineering design; experience; fly; gait examination; genetic analysis; high reward; high risk; imaging probe; improved; in vivo; in vivo Model; innovation; instrument; instrumentation; mHealth; micromanipulator; microscopic imaging; model development; molecular diagnostics; motor disorder; mouse model; neoplastic cell; neuroimaging; neurophysiology; nonhuman primate; novel; novel strategies; parkin gene/protein; practical application; pre-clinical; precision medicine; prenatal; problem drinker; programs; radio frequency; radiotracer; relating to nervous system; research and development; research clinical testing; research study; robotic device; signal processing; single molecule; software development; spectroscopic imaging; systems research; technology development; tempol; theories; three-dimensional modeling; transmission process; treadmill; two-photon; vocalization

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. SPIS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, SPIS staff review the clinical and biomedical sciences to formulate project specifications. SPIS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. SPIS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Example past and current collaborative projects, as well as associated research studies include: 1. Laser Capture Tissue Microdissection (LCM) for Molecular Analysis of Disease States and Normal Development Tissue Activated/Expression Microdissection (TAM, xMD, TAM, fTAM) (NICHD, NIDA, NIBIB, NCI, NIMH). 2. Electron Paramagnetic Resonance (EPR) Imaging of In Vivo Oxygen Status Associated with Cancer Treatment Studies (NCI, NINDS). 3. Technologies for Fly Optomotor Behavioral Analysis and Genetic Dissection of Color-vision Circuit Studies (NICHD). 4. Systems Enabling Study of Integration of Chromatic Information in the Higher Visual Center of Drosophila (NICHD). 5. A Microfluidic Platform for PNA-Based Molecular Diagnostics of HIV-1 (NIDDK, NIBIB). 6. Development of a Video-Based Tracking System for the Routine Clinical Evaluation of Motor Disorders (NIDA, NIA). 7. Electric Field Effects on Cells - Evaluation as Cancer Therapy (NICHD, NIBIB). 8. A Double-Blind, Placebo-Controlled, Randomized Human Laboratory Pilot Study of Baclofen in Anxious Alcoholics (NIAAA, NIDA). 9. High throughput systems to evaluate drug/chemicals in adult flies (NIDDK). 10. Analytical Ultracentrifugation Technologies (NIBIB). 11. Advanced Methods of Whole Mount Sectioning of Prostatectomy Specimens for Imaging, Diagnosis, and Pathology Studies - Correlating In Vivo Prostate MRI and Histopathology using Individualized MR-Based Molds (NCI). 12. System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) for Phenotyping and Cancer Treatment Evaluation (NCI, NIDDK, FDA). 13. Quantitative Fluorescence Lifetime Imaging for Disease Detection and Monitoring (NICHD, NCI, NIBIB). 14. Perfusion Bioreactor System facilitating 3D Skin Model Development for Cancer and Drug Efficacy Studies (NCI, NIBIB). 15. Tumor Cell Monitoring Strategies to Study the Effects of Microenvironment on Anti-cancer Drug Efficacy In Culture Monitoring and Control Technologies for Modeling In Vivo Conditions (NCI). 16. Using Light-sheet Microscopy to Understand Evoked Motor Sequence Generation in Drosophila (NIMH). 17. Engineering Retinal Therapies via Bioreactors & 3D Gels (NEI, NIBIB). 18. Smartphone Applications to Measure Risky Driving Behavior (NICHD). 19. Capsule Endoscopy Technologies for Video Stabilization and Localization (NLM, NIBIB, NCI, NIDDK). 20. Technologies to Study Rodent Vestibular Sensory Evoked Potentials (NIDCD). 21. Quantitative Characterization of Normal and Disease Cervix Tissue (NICHD, NHLBI). 22. High-resolution Gamma Imager and Positron Position Imager for Small Animal Imaging of Radioisotopes for Cancer Treatment (NCI, CC). 23. Radiochemistry Laboratory Instrumentation and Automation Enabling Radiotracer Development and Preclinical Neuroimaging Research (NIAAA). 24. Signal Processing of Autonomic Measures for Behavioral Neurophysiology (NIMH). 25. Phenotyping and behavior analysis for Top1mt/Parkin deficient mice (NCI). 26. Large-scale video monitoring study of effect of Drd2 gene on obesity (NIDDK). 27. Profiling activity of mice on Tempol diet (NCI). 28. Wireless Transmission of Anesthesiology Parameters in an MRI Environment (CC). 29. Spectral Domain Optical Coherence Tomography (OCT) for Tissue Motion Tracking and Skin Blood Volume Imaging (NHLBI, NICHD). 30. Photo Dynamic Therapy (PDT) Technologies Integrated with Cancer Imaging Probes (NCI, NIBIB). 31. A Handheld Field Deployable Hematoma Detector: A Practical Application of Motion as Signal in Near Infra-red Imaging (NICHD). 32. Two-Photon Excitation Fluorescence Microscopy (TPEFM) Motion Tracking to Study In-vivo Subcellular Structures (NHLBI). 33. Portable Fluorescence Camera System for Offsite Tumor Imaging (NCI, NIBIB). 34. Image-Based Robotic Targeting System to Control Micromanipulators for Living Biological Tissues (Brain/Spinal) Studies (NINDS). 35. Fly Treadmill Motion Tracking System for Studying Visual Orientation and Motion Detection (NICHD). 36. Functional Near Infrared Spectroscopy Imaging Technologies for the Study of Traumatic Brain Injury (NINDS, NICHD). 37. Fluorescence Photo Activation Localization 2D/3D Microscopy and Analysis System to Study Biological Processes (NCI, NIAID, NICHD, NIBIB). 38. Tissue Microarray (TMA) Technologies for Cancer Studies (NCI, Childrens National Medical Center). 39. Temporal-spectral Programmable Lighting for Health and Rhythm Entrainment (NICHD, OD, NINR, Lawrence Berkeley National Laboratory, and DOE). 40. Nonhuman Primate Maternal-fetal Monitoring System for Investigating the Effects of Prenatal Psychological Stress (NICHD). 41. Bronchial Tree 3D Models to Enable Development of Radio-frequency and Laser Ablation Methodologies (CC, NCI). 42. Obtaining Isolated IR Spectrum of Each Stage in the Polymerization of Abeta Oligomers (NHLBI, NIBIB). 43. Visible and IR Optical Scanning Spectrometry to Study Energy Transduction by Bacteriorhodopsin (NHLBI, NIBIB, NIST). 44. Muscle Tension Transients Collection and Analysis Technologies to Study Cardiomyopathy Mutations (NHLBI). 45. Real-time Fluorescence-Enhanced Imaging as an Aid to Cancer Surgery (NCI, NIBIB). 46. Methods to Identify Neural Substrates of Behavior in Flies - Flight Initiation Detection System (NIMH). 47. Technologies to Assess Saliva Production in Association with Sjogren Syndrome Studies (NIDCR). 48. High-Throughput Ultrasound-accelerated Tissue Fixation Technologies to Improve Biomolecule Preservation (NCI). 49. MRI Motion Artifacts Technologies to Generate Phantom Motion for the Study of Correction Strategies (NICHD). 50. Technologies for low-field MRI (NICHD). 51. Automated Fabrication Technologies for Hydrogels with Gradient of Compliance: Application to Cell Mechanotaxis and Durotaxis (NICHD). 52. High Resolution Vibrational Spectroscopic Imaging to Study Cellular Membranes (NIDDK). 53. Microfluidics, Microfabrication, and Microanalysis Technologies for Molecular Analysis and Biomedical Research (NIBIB, NIST). 54. Functional MRI Methodologies and Devices to Study Communication Disorders and Treatments (NIDCD). 55. Classification of Monkey Vocalizations for Neurophysiological Studies involving Auditory Processing (NIMH). 56. Genetics and Mechanisms of Pain - Developing a Mouse Model - A Non-injurious Assay to Study Mechanisms of Pharmacodynamics and Transmission of Noxious Stimulus (CC). 57. Functional MRI to Study Neural Processes Underlying Self-agency (NINDS). 58. Real-time Multispectral Endoscope Imaging as an Aid to Cancer Surgery and HPV Studies (NCI, NIBIB). 59. Gait Analysis Technologies (CC, NICHD). 60. cDNA and Protein Microarray Technologies (NCI, NHGRI, NIEHS). 61. Chromosome Microdissection Technologies (NICHD, NHGRI). 62. Single Molecule, DNA, and Chromatin Fiber Mechanics and Manipulation Technologies (NCI, NICHD). 63. Atomic Force Microscopy Imaging (NIAMS

信号处理和仪器部分（SPI）的研发活动是与NIH研究所科学家的合作努力，要求开发生物医学实验室和临床研究系统，仪器和方法论。 这些合作中的大多数都需要新颖的方法和设计，这些方法和设计的确定标准或技术知识最少。 SPIS员工在工程研发的所有阶段都有深入的技术经验。 SPIS员工凭借其合作者，审查了制定项目规格的临床和生物医学科学。 SPIS员工评估了理论和实用的约束，考虑市售技术，并最终提出了各种解决方案。 SPIS职责通常继续进行自定义研究系统或方法的动手设计，实施，测试，安装，培训，文档和生产。 示例过去和当前的协作项目以及相关的研究包括： 1。激光捕获组织显微解剖（LCM），用于疾病状态和正常发育组织激活/表达微分解的分子分析（TAM，XMD，TAM，FTAM）（NICHD，NIDA，NIDA，NIBIB，NCI，NIMH）。 2。与癌症治疗研究（NCI，NINDS）相关的体内氧状态的电子顺磁共振（EPR）成像。 3。苍蝇验光行为分析和色视电路研究（NICHD）的遗传解剖技术。 4。在果蝇高级视觉中心（NICHD）中的色彩信息整合的系统。 5。用于基于PNA的HIV-1分子诊断的微流体平台（NIDDK，Nibib）。 6。开发基于视频的跟踪系统，用于常规的运动障碍临床评估（NIDA，NIA）。 7。电场对细胞的影响 - 评估为癌症治疗（NICHD，NIBIB）。 8。一项双盲，安慰剂对照的，随机的人类实验室试点研究焦虑酒精中毒（NIAAA，NIDA）。 9。评估成年果蝇药物/化学物质的高通量系统（NIDDK）。 10。分析超速离心技术（Nibib）。 11。用于成像，诊断和病理研究的前列腺切除术标本的整个安装分段的高级方法 - 使用个性化基于MR的霉菌（NCI）将体内前列腺MRI和组织病理学相关联。 12。用于在家笼环境中连续观察啮齿动物的系统（SCORHE）进行表型和癌症治疗评估（NCI，NIDDK，FDA）。 13。用于疾病检测和监测的定量荧光寿命成像（NICHD，NCI，NIBIB）。 14。灌注生物反应器系统促进了3D皮肤模型开发的癌症和药物功效研究（NCI，Nibib）。 15。研究微环境对抗癌药物疗效在培养监测和控制技术中的抗癌药物疗效的影响（NCI）（NCI）。 16。使用灯页显微镜了解果蝇（NIMH）中诱发的运动序列产生。 17。通过生物反应器和3D凝胶（NEI，Nibib）的工程视网膜疗法。 18。智能手机应用程序以衡量冒险行为（NICHD）。 19。胶囊内窥镜技术用于视频稳定和定位（NLM，Nibib，NCI，NIDDK）。 20。研究啮齿动物前庭感觉诱发电位（NIDCD）的技术。 21。正常和疾病子宫颈组织的定量表征（NICHD，NHLBI）。 22。用于癌症治疗的小动物成像（NCI，CC）的高分辨率伽马成像仪和正电子位置成像仪。 23。放射化学实验室仪器和自动化，使放射性示踪剂的发展和临床前神经影像学研究（NIAAA）。 24。行为神经生理学（NIMH）的自主措施的信号处理。 25。top1mt/parkin缺乏小鼠（NCI）的表型和行为分析。 26。大规模视频监测研究DRD2基因对肥胖的影响（NIDDK）。 27。小鼠对tempol饮食（NCI）的分析活性。 28。在MRI环境（CC）中，麻醉参数的无线传输。 29。用于组织运动跟踪和皮肤血液体积成像的光谱域光学相干断层扫描（OCT）（NHLBI，NICHD）。 30。与癌症成像探针（NCI，Nibib）集成的照片动态疗法（PDT）技术。 31。手持式现场可部署血肿检测器：在近红外成像（NICHD）中，运动作为信号的实际应用。 32。两光子激发荧光显微镜（TPEFM）运动跟踪，以研究体内亚细胞结构（NHLBI）。 33。用于异地肿瘤成像的便携式荧光摄像头系统（NCI，Nibib）。 34。基于图像的机器人靶向系统控制生物组织（脑/脊柱）研究（NINDS）的微量操纵器。 35。用于研究视觉取向和运动检测（NICHD）的飞行跑步机运动跟踪系统。 36。用于研究创伤性脑损伤研究（NINDS，NICHD）的功能近红外光谱成像技术。 37。荧光照片激活定位2D/3D显微镜和分析系统研究生物学过程（NCI，NIAID，NICHD，NIBIB）。 38。癌症研究组织微阵列（TMA）技术（NCI，儿童国家医学中心）。 39。适用于健康和节奏夹带的时间光谱可编程照明（NICHD，OD，NINR，Lawrence Berkeley国家实验室和DOE）。 40。非人类灵长类动物孕产妇监测系统，用于研究产前心理压力（NICHD）的影响。 41。支气管树3D模型，以开发射频和激光消融方法（CC，NCI）。 42。在Abeta低聚物（NHLBI，Nibib）聚合中获得每个阶段的分离IR光谱。 43。可见和IR光学扫描光谱法研究了细菌紫红素（NHLBI，NIBIB，NIST）的能量转导。 44。研究心肌病突变（NHLBI）的肌肉张力瞬变和分析技术。 45。实时荧光增强成像作为癌症手术的帮助（NCI，Nibib）。 46。识别苍蝇行为的神经基质的方法 - 飞行起始检测系统（NIMH）。 47。与Sjogren综合征研究（NIDCR）评估唾液产生的技术。 48。高通量超声加速组织固定技术，以改善生物分子保存（NCI）。 49。MRI运动伪像技术为校正策略研究（NICHD）生成幻影运动。 50。低场MRI（NICHD）的技术。 51。具有合规性梯度的水凝胶的自动制造技术：应用于细胞机械的和Durotaxis（NICHD）。 52。研究细胞膜（NIDDK）的高分辨率振动光谱成像。 53。用于分子分析和生物医学研究（NIBIB，NIST）的微流体，微分析和微分析技术。 54。研究沟通障碍和治疗方法的功能性MRI方法和设备（NIDCD）。 55。涉及听觉加工（NIMH）的神经生理研究的猴子发声分类。 56。疼痛的遗传学和机制 - 开发小鼠模型 - 一种无害的测定，用于研究药效学和有害刺激的传播机制（CC）。 57.功能性MRI研究自我机构（NINDS）基础的神经过程。 58。实时多光谱内窥镜成像，以帮助癌症手术和HPV研究（NCI，NIBIB）。 59。步态分析技术（CC，NICHD）。 60。cDNA和蛋白质微阵列技术（NCI，NHGRI，NIEHS）。 61。染色体微分解技术（NICHD，NHGRI）。 62。单分子，DNA和染色质纤维力学和操纵技术（NCI，NICHD）。 63。原子力显微镜成像（NIAMS