Signal Processing And Instrumentation Section

信号处理和仪器部分

• 批准号: 7733761
• 负责人: THOMAS J POHIDA
• 金额: $ 69.69万
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733761
• 关键词: Algorithms; Atomic Force Microscopy; Biological Assay; Biomechanics; Chromatin Fiber; Clinical Research; Collaborations; Complementary DNA; Computer software; Custom; DNA; Development; Devices; Digital Signal Processing; Electron Spin Resonance Spectroscopy; Electronics; Engineering; Fetal Monitoring; Fluorescence Microscopy; Frequencies; Functional Magnetic Resonance Imaging; Goals; Health; Image; Institutes; Intramural Research Program; Lighting; Logic; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Mechanics; Methodology; Microdissection; Microfabrication; Microfluidics; Monitor; Mus; Nociception; Optics; Pain; Pathology; Positron-Emission Tomography; Printing; Process; Program Research Project Grants; Protein Microchips; Radio; Radionuclide Imaging; Research; Robotics; Scanning; Scientist; Signal Transduction; Software Engineering; Spectrometry; Speech; Speed; System; Techniques; Telemetry; Time; Tissue Microarray; Ultrasonography; United States National Institutes of Health; analog; base; chromosome microdissection; computer program; computerized data processing; data acquisition; design; digital; fluorescence imaging; gait examination; image processing; instrument; instrumentation; laser capture microdissection; nonhuman primate; prototype; research and development; simulation; single molecule; technology development; tissue processing; two-photon

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and signal analysis. SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and technology development at the NIH. Example technology developments and projects include: * cDNA and protein microarray * tissue microarray (TMA) * laser capture microdissection (LCM) * expression microdissection (xMD) * chromosome microdissection * microfluidics, microfabrication, and microanalysis * single molecule, DNA, and chromatin fiber mechanics and manipulation * high-speed scanning spectrometry * atomic force microscopy (AFM) * electron paramagnetic resonance (EPR) imaging * magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices * magnetic resonance elastography (MRE) imaging * ultrasound imaging * positron emission tomography (PET) imaging * gamma camera imaging * fluorescence imaging * two-photon excitation fluorescence microscopy (TPEFM) * speech acquisition and real-time adaptive processing * biomechanics real-time gait analysis * neuro-specific nociceptive assay for mouse pain studies * nonhuman primate maternal-fetal monitoring * automated mouse activity monitoring system (MAMS) * pathology tissue processing methodologies * spectrally programmable lighting for health and rhythm entrainment

信号处理和仪器科（SPI）的研发活动是与NIH Institute科学家的合作努力，并且通常会导致开发独特的专业生物医学工具。其他项目涉及系统模拟和信号分析所需的信号和视频处理算法开发。 SPIS的能力和成就已确立了该小组作为NIH工程研究和技术开发的焦点。示例技术发展和项目包括： * cDNA和蛋白质微阵列 *组织微阵列（TMA） *激光捕获微分解（LCM） *表达微分解（XMD） *染色体微分解 *微流体，微分析和微分析 *单分子，DNA和染色质纤维力学和操纵 *高速扫描光谱法 *原子力显微镜（AFM） *电子顺磁共振（EPR）成像 *磁共振成像（MRI）和功能性MRI（fMRI）方法和设备 *磁共振弹性图（MRE）成像 *超声成像 *正电子发射断层扫描（PET）成像 *伽玛相机成像 *荧光成像 *两光子激发荧光显微镜（TPEFM） *语音获取和实时自适应处理 *生物力学实时步态分析 *用于小鼠疼痛研究的神经特异性伤害性测定 *非人类灵长类动物孕产妇监测 *自动化鼠标活动监控系统（MAMS） *病理组织加工方法 *可用于健康和节奏夹带的可编程照明

项目成果

Arterial wall properties and Womersley flow in Fabry disease.

• DOI: 10.1186/1471-2261-2-1
• 发表时间: 2002-01-01
• 期刊: BMC cardiovascular disorders
• 影响因子: 2.1
• 作者: Moore, David F;Altarescu, Gheona;Schiffmann, Raphael
• 通讯作者: Schiffmann, Raphael

Expression microdissection: operator-independent retrieval of cells for molecular profiling.

表达显微切割：独立于操作员的细胞检索以进行分子分析。

• DOI: 10.1097/01.pdm.0000135964.31459.bb
• 发表时间: 2004
• 期刊: Diagnostic molecular pathology : the American journal of surgical pathology, part B
• 作者: Tangrea,MichaelA;Chuaqui,RodrigoF;Gillespie,JohnW;Ahram,Mamoun;Gannot,Gallya;Wallis,BenjaminS;Best,CarolynJM;Linehan,WMarston;Liotta,LanceA;Pohida,ThomasJ;Bonner,RobertF;Emmert-Buck,MichaelR
• 通讯作者: Emmert-Buck,MichaelR