Signal Processing And Instrumentation Section

信号处理和仪器部分

• 批准号: 8148478
• 负责人: THOMAS J POHIDA
• 金额: $ 72.4万
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8148478
• 关键词: computerized data processing; instrumentation

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and data analysis. SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and technology development at the NIH. Example technology and methodology development projects, as well as associated research studies include: 1. laser capture tissue microdissection (LCM) technologies for macromolecular analysis of normal development and pathology 2. expression tissue microdissection (xMD) methodologies enabling subcellular isolation for identification of organelle proteins 3. tissue microarray (TMA) technologies 4. two-photon excitation fluorescence microscopy (TPEFM) in-vivo methodologies 5. fluorescence photo activation localization microscopy (FPALM) nanoscale imaging 6. electron paramagnetic resonance (EPR) methodologies enabling in vivo functional and physiological imaging 7. cDNA and protein microarray technologies 8. magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices 9. gamma camera imaging for analyzing bio-distribution of putative diagnostic and therapeutic radiotracers 10. fluorescence imaging for disease detection, monitoring, and guided surgery 11. optical polarization imaging and statistical analysis for quantitative characterization of tissue 12. automated mouse activity monitoring system (MAMS) for quantitative behavioral assessment in facility cages 13. clinical pathology tissue fixation and sectioning methodologies 14. microfluidics, microfabrication, and microanalysis technologies for molecular analysis 15. single molecule, DNA, and chromatin fiber mechanics and manipulation technologies 16. temporal and spectral programmable lighting technologies for health and rhythm entrainment 17. correlating in vivo prostate MRI and histopathology using individualized MR-Based molds 18. fly optomotor behavioral analysis and genetic dissection of color-vision circuits methodologies 19. autonomic measures for behavioral neurophysiology instrumentation and methodologies 20. vibrational spectroscopic near-field scanning microscopy imaging for nanoscale analysis of dynamical, conformational and organizational characteristics of cells and tissues 21. photodynamic therapy (PDT) technologies for cancer treatment 22. speech acquisition, analysis, and real-time adaptive processing methodologies 23. nonhuman primate maternal-fetal monitoring technologies for investigation of psychological, physiological, and behavior processes during fetal development 24. biomechanics real-time measurement and analysis technologies 25. muscle fiber tension transient instrumentation and analysis technologies 26. automated stimulation and monitoring instrumentation for investigation of genetics and neuro-specific transmission mechanisms of pain via mouse model assays 27. high-speed scanning optical spectrometry for analysis of bacteriorhodopsin energy transduction mechanisms 28. real-time multispectral endoscope imaging as an aid to surgery 29. positron emission tomography (PET) imaging 30. confocal microscopy imaging 31. chromosome microdissection technologies 32. non-invasive real-time in-vivo infrared imaging for assessment of endothelial function 33. atomic force microscopy (AFM) imaging 34. magnetic resonance elastography (MRE) imaging 35. ultrasound imaging

信号处理和仪器科（SPI）的研发活动是与NIH Institute科学家的合作努力，并且通常会导致开发独特的专业生物医学工具。其他项目涉及系统模拟和数据分析所需的信号和视频处理算法开发。 SPIS的能力和成就已确立了该小组作为NIH工程研究和技术开发的焦点。示例技术和方法发展项目以及相关研究包括： 1。激光捕获组织显微解剖（LCM）技术，用于正常发育和病理的大分子分析 2。表达组织显微解剖（XMD）方法，实现了亚细胞分离以鉴定细胞器蛋白 3。组织微阵列（TMA）技术 4。两光子激发荧光显微镜（TPEFM）体内方法论 5。荧光照片激活定位显微镜（FPALM）纳米级成像 6。电子顺磁共振（EPR）方法，使体内功能和生理成像具有 7。cDNA和蛋白质微阵列技术 8。磁共振成像（MRI）和功能性MRI（fMRI）方法和设备 9。用于分析推定诊断和治疗性放射性示例的生物分布的伽马相机成像 10。用于疾病检测，监测和指导手术的荧光成像 11。用于组织定量表征​​的光学极化成像和统计分析 12。自动化的鼠标活动监控系统（MAMS）用于定量行为评估设施笼 13。临床病理组织固定和切片方法 14。用于分子分析的微流体，微分析和微分析技术 15。单分子，DNA和染色质纤维力学和操纵技术 16.健康和节奏夹带的时间和光谱可编程照明技术 17。使用个性化基于MR的模具将体内前列腺MRI和组织病理学相关联 18。苍蝇验光行为分析和颜色视频电路方法的遗传解剖方法 19。行为神经生理学仪器和方法论的自主措施 20。振动光谱近场扫描显微镜成像，用于细胞和组织的动力学，构象和组织特征的纳米级分析 21。用于癌症治疗的光动力疗法（PDT）技术 22。语音采集，分析和实时自适应处理方法 23。非人类灵长类动物孕产妇监测技术，用于调查胎儿发育过程中心理，生理和行为过程 24。生物力学实时测量和分析技术 25。肌肉纤维张力瞬态仪器和分析技术 26。通过小鼠模型测定法调查遗传学和神经特异性传播机制的自动刺激和监测仪器 27。高速扫描光谱法，用于分析细菌蛋白能量转导机制 28.实时多光谱内窥镜成像作为手术的帮助 29。正电子发射断层扫描（PET）成像 30。共聚焦显微镜成像 31。染色体微分解技术 32。非侵入性实时体内红外成像用于评估内皮功能 33。原子力显微镜（AFM）成像 34。磁共振弹性图（MRE）成像 35。超声成像