SYNERGY: The Dartmouth Center for clinical and Translational Science

SYNERGY：达特茅斯临床和转化科学中心

• 批准号: 9274366
• 负责人: ALAN I GREEN
• 金额: $ 66.86万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274366
• 关键词: Basic Science; Biological Sciences; Biology; Clinical Research; Clinical Sciences; Discipline; Disease; Ensure; Funding; Goals; Health; Health Policy; Health Services Research; Home environment; Institution; Instruction; Interdisciplinary Education; Knowledge; Medicine; Names; Population Research; Productivity; Program Development; Recording of previous events; Research; Research Personnel; Resources; Science; Services; Training; Translational Research; Translations; authority; career; career development; clinical care; design; improved; member; population health; programs; synergism

The overarching goal of this proposal is to support and enhance our institutionally-funded Dartmouth Center for Clinical and Translational Science, called SYNERGY-an integrated home for clinical and translational science at Dartmouth. Dartmouth launched SYNERGY in 2010, a Center built on Dartmouth's richly collaborative and collegial culture, its interdisciplinary life sciences and health services research programs, and its commitment to accelerating the translation of scientific knowledge into practice and improved population health. Over the past two years, fueled by Dartmouth's resources, and by the "Center status" and authority given by Dartmouth's leaders, SYNERGY has taken bold steps to begin to transform the institution's landscape for clinical and translational research. We propose four overarching aims designed to continue to expand our ability to conduct decisive science on the biology of disease and to use new and existing knowledge to transform the practice of medicine and thus to improve health-locally, regionally and nationally. Over the next five years we will: (1) strengthen SYNERGY to achieve greater interdisciplinary and programmatic research synergism and efficiency and promote an institutional culture aimed at advancing clinical and translational science; (2) ensure that SYNERGY investigators can easily and efficiently access resources and services, and thus enhance their productivity; (3) expand and integrate training and career development programs to build research focus and passion among trainees from diverse disciplines who aim to build successful careers in clinical and translational research; and (4) create a Center for Translational Population Research , a technical and analytic resource that harnesses the value of population-based research across the spectrum from T l (basic research) to T4 (population research and health policy), as a resource both for Dartmouth and forthe national CTSA consortium. Dartmouth is united to ensure that SYNERGY will continue to transform the landscape for clinical and translational research locally, regionally, and-as a member of the CTSA consortium-nationally, and thus to improve population health. RELEVANCE (See instructions): Dartmouth has a history of collaborative research and interdisciplinary education in the life sciences and health services research that have led to the creation of Dartmouth's Center for Clinical and Translational Science, named SYNERGY. As proposed in this application, SYNERGY will be expanded to support the efficient and rapid translation of scientific findings into clinical care and improved population health.

该提案的总体目标是支持和加强我们机构资助的达特茅斯中心 临床和转化科学，称为 SYNERGY——临床和转化科学的综合家园 达特茅斯的科学。达特茅斯于 2010 年推出了 SYNERGY，这是一个建立在达特茅斯丰富的资源基础上的中心 协作和学院文化、跨学科生命科学和健康服务研究项目、 及其致力于加速科学知识转化为实践和改进的承诺 人口健康。过去两年，在达特茅斯资源的推动下，以及“中心地位”和 在达特茅斯领导层的授权下，SYNERGY 已采取大胆步骤开始转变 机构的临床和转化研究景观。我们提出四个总体目标，旨在 继续扩大我们对疾病生物学进行决定性科学研究的能力，并利用新的和 现有知识来改变医学实践，从而改善当地、区域和地区的健康 全国范围内。未来五年，我们将：（1）加强协同，实现更大的跨学科和 计划性研究的协同作用和效率，并促进旨在推进的机构文化 临床和转化科学； (2) 确保SYNERGY调查人员能够轻松高效地访问 资源和服务，从而提高生产力； (3)拓展和整合培训和职业 发展计划，旨在培养来自不同学科的学员的研究重点和热情 在临床和转化研究领域建立成功的职业生涯； (4) 创建一个转化中心 人口研究，一种利用基于人口的价值的技术和分析资源 从Tl（基础研究）到T4（人口研究和卫生政策）的跨领域研究，作为 达特茅斯学院和国家 CTSA 联盟的资源。达特茅斯团结一致，确保 SYNERGY 将继续改变本地、区域性临床和转化研究的格局， - 作为 CTSA 联盟的成员 - 在全国范围内，从而改善人口健康。 相关性（参见说明）： 达特茅斯在生命科学领域有着合作研究和跨学科教育的历史 卫生服务研究促成了达特茅斯临床和转化中心的创建 科学，名为SYNERGY。正如本申请中所提议的，SYNERGY 将进行扩展以支持 将科学发现高效、快速地转化为临床护理并改善人口健康。

项目成果

Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

他汀类药物可降低某些肺癌组织学亚型患者的死亡率。

• DOI: 10.1016/j.lungcan.2018.10.022
• 发表时间: 2018
• 期刊: Lung cancer (Amsterdam, Netherlands)
• 作者: Ung,MatthewH;MacKenzie,ToddA;Onega,TracyL;Amos,ChristopherI;Cheng,Chao
• 通讯作者: Cheng,Chao

What is hepcidin telling us about the natural history of cystic fibrosis?

铁调素告诉我们有关囊性纤维化自然史的什么信息？

• DOI: 10.1016/j.jcf.2014.03.012
• 发表时间: 2015
• 期刊: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
• 作者: Gifford,AH

Machine Learning Based Classification of Deep Brain Stimulation Outcomes in a Rat Model of Binge Eating Using Ventral Striatal Oscillations.

• DOI: 10.3389/fpsyt.2018.00336
• 发表时间: 2018
• 期刊: Frontiers in psychiatry
• 影响因子: 4.7
• 作者: Doucette WT;Dwiel L;Boyce JE;Simon AA;Khokhar JY;Green AI
• 通讯作者: Green AI

Patient-specific factors associated with pressure injuries revealed by electronic health record analyses.

电子健康记录分析揭示了与压力性损伤相关的患者特定因素。

• DOI: 10.1177/1460458219832053
• 发表时间: 2020
• 期刊: Health informatics journal
• 影响因子: 3
• 作者: Miller,MeganW;Emeny,RebeccaT;Snide,JenniferA;Freed,GaryL
• 通讯作者: Freed,GaryL

Reduction of Hospital-acquired Pressure Injuries Using a Multidisciplinary Team Approach: A Descriptive Study.

使用多学科团队方法减少医院获得性压力损伤：一项描述性研究。

• 发表时间: 2019
• 期刊: Wounds : a compendium of clinical research and practice
• 作者: Miller,MeganW;Emeny,RebeccaT;Freed,GaryL
• 通讯作者: Freed,GaryL