Using Text Messaging to Increase HPV Vaccination among Young Sexual Minority Men

使用短信增加年轻性少数男性的 HPV 疫苗接种

基本信息

批准号：
9302703
负责人：
Mary A Gerend
金额：
$ 20.88万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9302703
关键词：
Address Advisory Committees Affect Age Age-Years Anus Area Attention Behavioral Bisexual Cancer Etiology Cellular Phone Chicago Computer software Country Cues Data Dose Education Electronic Mail Ensure Evidence based intervention Female Female Adolescents Focus Groups Gays Goals HIV Seropositivity HPV-High Risk Health Heterosexuals Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papillomavirus Human papilloma virus infection Illinois Immunization Intervention Letters Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of penis Medical Records Modeling Morbidity - disease rate Motivation Outcome Outcome Measure Papillomavirus Infections Participant Population Procedures Process Protocols documentation Randomized Randomized Controlled Trials Recruitment Activity Registries Research Sampling Series Sexual Health Sexual and Gender Minorities Sexually Transmitted Diseases Telephone Testing Text Time United States Vaccinated Vaccination Vaccines Work aged base cancer risk design efficacy testing evidence base high risk population male malignant oropharynx neoplasm men men who have sex with men mortality disparity prevent primary outcome programs queer response satisfaction sexual health intervention sexual minority sexually active skills uptake young adult young men who have sex with men

项目摘要

Project Summary/Abstract Human papillomavirus (HPV) is a common sexually transmitted infection that causes anal, penile, oropharyngeal cancers in men. Due to their sexual practices, men who have sex with men (MSM) are at particularly high risk for HPV infection and are disproportionately affected by HPV-related cancers. A safe and effective vaccine is available to prevent HPV infection, yet HPV vaccination rates in the U.S. have been low, particularly among males. The Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all MSM through age 26. Nevertheless, recent studies with national samples of gay and bisexual men aged 18-26 indicate that only 13-21% have initiated the 3-dose HPV vaccine series. Our pilot work suggests that many MSM are simply unaware of the vaccine or perceive other important barriers to getting vaccinated. To remedy this gap, the goal of the proposed research is to develop and pilot test a text messaging intervention to increase HPV vaccination in young MSM. The proposed intervention combines an evidence-based approach to increasing vaccination (“reminder-recall”) with text messaging. In addition to providing basic education and a cue to action, text messages can be tailored to address specific barriers. The long-term goal of this research is to develop effective strategies for increasing HPV vaccination among MSM, thereby reducing morbidity, mortality, and disparities associated with HPV-related cancers. In response to PA- 15-263 (The Health of Sexual and Gender Minority Populations), the objective of this R21 application is to develop and pilot test a text messaging intervention to increase HPV vaccination in young adult MSM. Guided by the Information, Motivation, and Behavioral Skills (IMB) Model, we propose to two specific aims: (1) Develop, iteratively refine, and pre-test messages using a 5-step formative research procedure. Intended users of the program (i.e., men who identify as gay, bisexual, or queer 18-26 years old) will be recruited to assist with this process. (2) Test the feasibility, acceptability, and preliminary efficacy of the Txt4Prevention (T4P) text messaging intervention in a pilot randomized controlled trial (RCT). Participants will be randomized to the treatment (T4P) or control condition. The treatment condition will receive a culturally appropriate HPV vaccination intervention based on the IMB model, whereas the control condition will receive a general sexual health intervention that includes basic facts about HPV vaccination readily accessible online. Primary outcome measures include intervention feasibility (recruitment and retention), acceptability (satisfaction with the intervention), and preliminary efficacy as determined by initiation and completion of the 3-dose series at the end of the 9-month trial. Vaccination status will be verified by participants' medical records and the Illinois Immunization Registry. Outcomes from these aims are expected to have an important positive impact by identifying effective strategies for increasing HPV vaccination among sexual minority men.

项目概要/摘要人乳头瘤病毒 (HPV) 是一种常见的性传播感染，可导致肛门、阴茎、男性口咽癌由于其性行为，男男性行为者 (MSM) 处于危险之中。 HPV 感染的风险特别高，并且受 HPV 相关癌症的影响尤为严重。有有效的疫苗可以预防 HPV 感染，但美国的 HPV 疫苗接种率一直很低，特别是在男性中，免疫实践咨询委员会 (ACIP) 建议接种 HPV。所有 26 岁以下的男男性接触者 (MSM) 都必须接种疫苗。然而，最近对全国同性恋和男同性恋者样本进行的研究 18-26 岁的双性恋男性表明，只有 13-21% 的人开始接种 3 剂 HPV 疫苗系列。研究表明，许多 MSM 根本不知道疫苗或认为存在其他重要障碍为了弥补这一差距，拟议研究的目标是开发和试点测试文本。消息传递干预措施旨在增加年轻 MSM 的 HPV 疫苗接种。拟议的干预措施结合了以下措施：除了短信之外，还采用基于证据的方法来增加疫苗接种（“提醒回忆”）。短信可以提供基础教育和行动提示，可以针对特定障碍进行定制。这项研究的长期目标是制定有效的策略来增加 MSM 中的 HPV 疫苗接种，从而降低与 HPV 相关癌症相关的发病率、死亡率和差异。 15-263（性少数群体的健康），此 R21 应用程序的目标是开发并试点测试短信干预措施，以增加年轻 MSM 的 HPV 疫苗接种。通过信息、动机和行为技能（IMB）模型，我们提出两个具体目标：（1）使用 5 步形成性研究程序开发、迭代完善和预先测试消息。该计划的成员（即 18-26 岁的同性恋、双性恋或酷儿）将被招募来协助（2）测试Txt4Prevention（T4P）文本的可行性、可接受性和初步功效试点随机对照试验 (RCT) 中的消息传递干预参与者将被随机分配到治疗 (T4P) 或对照条件治疗条件将接受适合文化的 HPV。基于IMB模型的疫苗接种干预，而对照条件将接受一般性的干预健康干预措施，包括可在线获取的有关 HPV 疫苗接种的基本事实。措施包括干预的可行性（招聘和保留）、可接受性（对干预），以及根据 3 剂量系列的开始和完成确定的初步疗效 9 个月试验结束后，疫苗接种状况将通过参与者的医疗记录和伊利诺伊州进行验证。这些目标的成果预计将产生重要的积极影响。增加性少数男性 HPV 疫苗接种的有效策略。