Using Message Framing to Promote HPV Vaccination

使用消息框架促进 HPV 疫苗接种

基本信息

批准号：
7616276
负责人：
Mary A Gerend
金额：
$ 7.26万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-17 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7616276
关键词：
12 year old Advisory Committees Affective Age Anogenital venereal warts Behavior Behavior Therapy Caring Child Clinical Trials Cognitive Condition Development Effectiveness Effectiveness of Interventions Exposure to Female Fostering Gardasil Genital Human Papilloma Virus Infection Goals HPV-High Risk Health Health Communication Health behavior Health behavior change Human Human Papilloma Virus Vaccine Human Papillomavirus Human papilloma virus infection Immunization Incidence Infection Intervention Left Malignant neoplasm of cervix uteri Mediating Mediator of activation protein Medical Methods Morbidity - disease rate Pap smear Papillomavirus Parents Participant Perception Population Prevention Public Health Purpose Randomized Range Rate Relative (related person)Research Sampling Scientist Screening for cancer Self Efficacy Sexually Transmitted Diseases Standards of Weights and Measures Telephone Testing Translating United States United States Food and Drug Administration Vaccinated Vaccination Vaccines Woman base behavior change burden of illness communication theory cost design follow-up girls improved insight interest mortality pediatrician preadolescence prophylactic psychologic research study theories therapy design university student uptake young adult

项目摘要

DESCRIPTION (provided by applicant): Persistent infection with a sexually transmitted infection known as human papillomavirus (HPV) is the primary cause of cervical cancer. Although Pap testing has significantly reduced the incidence of cervical cancer in the U.S., nearly 4,000 women died of cervical cancer in 2007. A prophylactic quadrivalent HPV vaccine (Gardasil) was recently approved for girls and women ages 9-26. The vaccine protects against infection by four HPV types responsible for over 90% of all genital warts and 70% of all cervical cancers. Routine HPV vaccination is recommended in girls ages 11-12 and "catch-up" vaccination among girls/women ages 13-26 who have not been vaccinated previously. Studies conducted before Gardasil's release found that young women expressed keen interest in the vaccine. Whether high acceptability will translate into high rates of vaccination, however, is unclear. In addition, little is known about effective methods for promoting HPV vaccination in young adults. The proposed research therefore will evaluate a behavioral intervention aimed at promoting catch-up vaccination among female college students, a population that is at high risk for HPV infection. The proposed intervention will apply the use of message framing, a theoretically grounded health communication strategy that involves motivating health behavior change through presentation of equivalent appeals framed in terms of either gains or losses. Message framing has proven to be a highly effective strategy for promoting behavior change across a wide range of health practices, including cancer screening and prevention behaviors. The first aim of the proposed randomized controlled experiment is to assess the effectiveness of a loss-framed intervention (relative to a gain-framed intervention and standard-of-care control) in promoting catch-up HPV vaccination. At baseline, participants will be randomly assigned to one of three interventions (loss, gain, control). Follow-up assessments will be conducted by telephone 2 and 8 months later to assess HPV vaccination status. Based on theory and previous research, exposure to a loss-framed intervention is hypothesized to increase HPV vaccination rates relative to the other two conditions. The second aim is to identify mediators of the intervention effect. Although several studies have attempted to uncover the cognitive and affective mechanisms underlying the effects of framed health messages on behavior, relatively few have been successful. In the proposed research, observed framing effects are expected to be mediated by increases in both perceived vulnerability to HPV infection and self-efficacy to receive the HPV vaccine. HPV infection represents a tremendous threat to public health. It is responsible for increasing medical costs, as well as the psychological and disease burden associated with abnormal Pap testing, genital warts, and cervical cancer. The long-term objectives of the proposed research are to facilitate the development of theory-based health communication interventions for promoting HPV vaccination and, ultimately, to reduce the incidence of cervical cancer.

描述（由申请人提供）：持续感染被称为人乳头瘤病毒（HPV）的性传播感染是宫颈癌的主要原因。尽管子宫颈抹片检查显着降低了美国宫颈癌的发病率，但 2007 年仍有近 4,000 名女性死于宫颈癌。预防性四价 HPV 疫苗 (Gardasil) 最近被批准用于 9-26 岁的女孩和妇女。该疫苗可预防四种 HPV 类型的感染，这四种类型的 HPV 导致 90% 以上的尖锐湿疣和 70% 的宫颈癌。建议 11-12 岁的女孩常规接种 HPV 疫苗，并为之前未接种疫苗的 13-26 岁的女孩/女性“补种”疫苗。加德西 (Gardasil) 发布之前进行的研究发现，年轻女性对该疫苗表现出浓厚的兴趣。然而，高可接受性是否会转化为高疫苗接种率尚不清楚。此外，对于促进年轻人接种 HPV 疫苗的有效方法知之甚少。因此，拟议的研究将评估旨在促进女大学生（HPV 感染高危人群）补种疫苗接种的行为干预措施。拟议的干预措施将采用信息框架，这是一种基于理论的健康传播策略，涉及通过呈现以收益或损失为框架的同等诉求来激励健康行为改变。消息框架已被证明是一种非常有效的策略，可以促进广泛的健康实践（包括癌症筛查和预防行为）的行为改变。拟议的随机对照实验的首要目的是评估损失框架干预（相对于增益框架干预和护理标准控制）在促进 HPV 疫苗接种补种方面的有效性。在基线时，参与者将被随机分配到三种干预措施之一（损失、增益、控制）。 2个月和8个月后将通过电话进行后续评估，以评估HPV疫苗接种状况。根据理论和之前的研究，假设相对于其他两种情况，接受损失框架干预可以提高 HPV 疫苗接种率。第二个目标是确定干预效应的中介因素。尽管一些研究试图揭示框架健康信息对行为影响的认知和情感机制，但成功的研究相对较少。在拟议的研究中，观察到的框架效应预计是通过感知 HPV 感染的脆弱性和接受 HPV 疫苗的自我效能的增加来介导的。 HPV 感染对公共健康构成巨大威胁。它导致医疗费用增加，以及与巴氏涂片检查异常、尖锐湿疣和宫颈癌相关的心理和疾病负担。拟议研究的长期目标是促进基于理论的健康传播干预措施的发展，以促进 HPV 疫苗接种，并最终降低宫颈癌的发病率。