HPV Vaccination among Low-Income Hispanic Adolescents

低收入西班牙裔青少年的 HPV 疫苗接种

基本信息

批准号：
8915347
负责人：
Mary A Gerend
金额：
$ 11.04万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-21 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8915347
关键词：
Acculturation Address Adolescent Affect Anogenital cancer Behavior Cancer Etiology Cause of Death Child Data Daughter Development Disease Dose Effectiveness Ensure Family Female Female Adolescents Florida Future Goals Health Health behavior Hispanics Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papillomavirus Incidence Infectious Agent Intervention Interview Knowledge Latina Left Life Literature Longitudinal Studies Low income Malignant Neoplasms Malignant neoplasm of cervix uteri Medical Records Modeling Morbidity - disease rate Mothers Not Hispanic or Latino Outcome Planning Theory Play Population Prevention strategy Primary Prevention Psychosocial Factor Research Risk Role Sampling Series Son Surveys Testing Theoretical model United States Vaccination Vaccines Work aged base cancer prevention cancer risk cancer type design effective intervention health belief high risk innovation insight mortality prevent primary outcome programs psychosocial success theories vaccine effectiveness

项目摘要

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) vaccination is a safe and effective primary prevention strategy for cervical cancer and other anogenital cancers, yet vaccination rates are remarkably low. Only 53% of adolescent females have initiated the vaccine (received �1 dose). More importantly, far fewer (35%) have completed the 3-dose series, which is vital for effective cancer prevention. Moreover, there are growing disparities in HPV vaccine completion rates, with Hispanic females significantly less likely to complete the series than non-Hispanic Whites. Low rates of vaccine completion are of crucial concern for populations disproportionally affected by HPV-related disease such as Latinas, whose cervical cancer incidence rates are 60% higher than in non- Hispanic Whites. Although studies have examined predictors of HPV vaccine initiation, there is a fundamental gap in the literature about predictors of series completion. Because receipt of all 3 doses is essential for maximum protection against HPV, identifying factors that influence whether Hispanic adolescents complete the series is critical for informing future intervention efforts. The long-term goal of ths research program is to develop effective strategies for increasing HPV vaccine completion among low-income Hispanic adolescents, thereby reducing morbidity, mortality, and disparities associated with HPV-related disease. The objective of this application is to determine key predictors of HPV vaccine completion, with special emphasis on identifying modifiable psychosocial and cultural factors associated with completion of the series. We propose two specific aims: (1) Determine key predictors of HPV vaccine completion (receipt of all 3 doses) among low-income Latina mothers of adolescents who have received the first dose of HPV vaccine and (2) Provide complementary qualitative information about facilitators and barriers that play an important role in HPV vaccine completion. To achieve Aim 1 we will conduct a yearlong longitudinal study of low-income Latina mothers whose adolescent daughter/son initiates the HPV vaccine. At baseline, both mothers and their daughter/son (aged 9-17) will complete a survey to assess cultural (e.g., acculturation) and psychosocial factors (e.g., perceived barriers to completion, subjective norms for completing the series) from major theories of health behavior (Health Belief Model, Theory of Planned Behavior). These variables will be used to predict our primary outcome variable: HPV vaccine completion status, as verified by the child's medical record. To achieve Aim 2 we will conduct in-depth qualitative interviews with a purposive sample of mothers from the longitudinal study. The goal of these interviews is to provide greater insight into cultural/psychosocial factors associated with completion, to identify factors related to completion not reflected in traditional theories of health behavior, an to investigate factors that may arise after mothers complete the baseline assessment. Outcomes from this project are expected to have an important positive impact by advancing knowledge needed to develop effective strategies for increasing HPV vaccine completion rates among low-income Hispanic adolescents.

描述（由申请人提供）：人乳头瘤病毒 (HPV) 疫苗接种是宫颈癌和其他肛门生殖器癌症安全有效的一级预防策略，但疫苗接种率却异常低，只有 53% 的青少年女性开始接种疫苗（接种 1）。更重要的是，完成 3 剂系列疫苗的人数要少得多 (35%)，而这对于有效预防癌症至关重要，此外，HPV 疫苗完成率的差异越来越大，西班牙裔女性的比例明显较低。疫苗完成率低是受 HPV 相关疾病影响较大的人群（例如拉丁裔）的一个重要问题，他们的宫颈癌发病率比非西班牙裔白人高 60%。已经检查了 HPV 疫苗接种的预测因素，但文献中关于系列完成的预测因素存在根本性空白，因为接受所有 3 剂疫苗对于最大限度地预防 HPV 至关重要，因此确定影响西班牙裔青少年是否完成该系列疫苗的因素至关重要。 THs 研究计划的长期目标是制定有效策略，提高低收入西班牙裔青少年的 HPV 疫苗接种率，从而降低与 HPV 相关疾病相关的发病率、死亡率和差异。该应用程序旨在确定 HPV 疫苗完成的关键预测因素，特别强调确定与完成该系列疫苗相关的可改变的社会心理和文化因素。我们提出两个具体目标：(1) 确定 HPV 疫苗完成的关键预测因素（收到）。接种第一剂 HPV 疫苗的青少年的低收入拉丁裔母亲，以及 (2) 提供有关在完成 HPV 疫苗过程中发挥重要作用的促进因素和障碍的补充定性信息。对青春期女儿/儿子开始接种 HPV 疫苗的低收入拉丁裔母亲进行为期一年的纵向研究在基线时，母亲及其女儿/儿子（9-17 岁）将完成一项调查以评估文化（例如，文化适应）和主要健康行为理论（健康信念模型、计划行为理论）中的心理社会因素（例如，完成该系列的感知障碍、完成该系列的主观规范）这些变量将用于预测我们的主要结果变量：HPV。疫苗接种完成情况，由孩子的医疗记录验证。为了实现目标 2，我们将对纵向研究中的母亲样本进行深入的定性访谈。这些访谈的目的是更深入地了解文化/心理社会因素。与完成相关的因素，以确定传统健康行为理论中未反映的与完成相关的因素，并调查母亲完成基线评估后可能出现的因素，预计该项目的结果将通过推进所需的知识产生重要的积极影响。制定有效策略，提高低收入西班牙裔青少年的 HPV 疫苗接种率。