Studies in HIV-1 Pathogenesis and Transmission

HIV-1 发病机制和传播研究

基本信息

批准号：
9249649
负责人：
Bharat Ramratnam
金额：
$ 16.15万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-10 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9249649
关键词：
Acetates Adult Anatomy Award Basic Science Benchmarking Biopsy CD4 Positive T Lymphocytes Caring Cells Cervical Chemical Agents Chemical Injury Clinic Clinical Management Clinical Medicine Clinical Research Clinical Research Protocols Collection Cream Data Dependency Disease Dose Dyspareunia Enrollment Environment Epithelial Epithelium Equilibrium Estrogens Exposure to Female Fertility Foundations Funding Gene Expression Generations Goals Grant HIV HIV-1 Hormonal Hormones Hospitals Human Immunologics Individual Infection Inflammatory Injury Instruction Integration Host Factors International AIDS Laboratories Life Cycle Stages Longevity Longitudinal Studies Low Dose Oral Contraceptives Macaca Measures Mediating Menstrual cycle Mentors Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Morphology Mucous Membrane Nonoxynol 9 Oral Contraceptives Organ Culture Techniques Pathogenesis Pattern Peer Review Phase Play Postmenopause Predisposition Premenopause Principal Investigator Privatization Process Productivity Progesterone Proteins Proteomics Publications Recruitment Activity Research Research Design Research Infrastructure Research Personnel Research Project Grants Risk Role SIV Safety Sampling Series Simplexvirus Site Survivors Techniques Testing Thinness Tight Junctions Time Tissue imaging Tissues Training Ulcer United States National Institutes of Health Universities Vagina Vaginal Douching Vaginal Itching Viral Virus Woman alcohol research antimicrobial base career career development cervicovaginal cohort cytokine design estrogenic genome-wide analysis hormonal contraception immunoregulation in vivo irritation laboratory experiment macrophage patient oriented research pressure programs protein expression public health relevance reduce symptoms reproductive hormone reproductive tract response sex sexual assault sexual trauma sexual violence simian human immunodeficiency virus translational study transmission process

项目摘要

DESCRIPTION (provided by applicant): The major goal of this Mid-Career Investigator Award in HIV related Patient-Oriented Research is to use the resulting protected time and effort to mentor a new generation of junior investigators at Brown University and its affiliated hospitals in translational studies of HIV pathogenesis and transmission. Mentees will be recruited from a robust educational infrastructure that includes several NIH funded HIV-centric programs including training grants (T32DA013911, T32MH078788, T32AA007459), international AIDS training and research programs (D43TW000237, D43TW009597) and Center grants including the Lifespan/Tufts/Brown CFAR (P30AI042853) and the Brown University Alcohol Research Center on HIV (P01AA019072). A recently funded 5-year research grant (R01HD072693) will be used as an immediately available foundation for mentoring and will allow instruction in patient oriented research that connects the clinic and laboratory with the pursuit of the following specifi aims (Aim 1) To quantify the effect of exogenous and endogenous reproductive hormones on HIV susceptibility of the reproductive tract of pre- and post-menopausal women. (Aim 2) To determine if reproductive hormones alter mechanisms responsible for HIV transmission through cervicovaginal epithelia. (Aim 3) To quantify the effect of reproductive hormones on HIV dependency factors in the female genital tract. The K24 mechanism will be used to support a new aim involving the longitudinal study of the cervicovaginal tract of adult women victims of sexual violence with the goal of characterizing inflammatory changes that result from sexual trauma. Pursuit of these aims will allow mentees to receive broad instruction on the design and management of clinical research protocols, collection and processing of biologic samples and execution of laboratory experiments involving state-of-the-art techniques in gene and protein expression and tissue imaging. Benchmarks for evaluating the progress of this K24 application will include the productivity of mentees measured by the number of abstracts, presentations and peer-reviewed publications as well as the number of career developments grants (NIH K- series, private foundation) that result from my patient oriented research program.

描述（由申请人提供）：这项中期研究员艾滋病毒中与患者的研究人员奖的主要目标是利用由此产生的受保护的时间和精力来指导布朗大学及其附属医院的新一代初级调查员 HIV发病机理和传播的翻译研究。将从强大的教育基础架构中招募受训者，其中包括几个以NIH资助的HIV中心计划，包括培训补助金（T32DA013911，T32MH078788，T32AA007459），国际辅助培训和研究计划（D43TW000237，D437，d43tw00959797）（P30AI042853）和艾滋病毒的布朗大学酒精研究中心（P01AA019072）。 A recently funded 5-year research grant (R01HD072693) will be used as an immediately available foundation for mentoring and will allow instruction in patient oriented research that connects the clinic and laboratory with the pursuit of the following specifi aims (Aim 1) To quantify the effect of exogenous and endogenous reproductive hormones on HIV susceptibility of the reproductive tract of pre- and post-menopausal women. （AIM 2）确定生殖激素是否改变了负责通过宫颈阴道上皮的艾滋病毒传播的机制。（目标3）量化生殖激素对女性生殖道中HIV依赖性因子的影响。 K24机制将用于支持一个新的目标，涉及对成年女性性暴力受害者宫颈阴道界的纵向研究，其目的是表征性创伤引起的炎症变化。对这些目标的追求将使受训者可以接受有关临床研究方案的设计和管理，收集和处理生物样品的设计和管理，以及涉及基因表达和蛋白质表达和组织成像的最新技术的实验室实验的执行。评估本k24应用程序进度的基准将包括由我的面向患者的研究计划产生的摘要，演示和同行评审的出版物的数量和同行评审的出版物的生产率（NIH K-系列，私人基金会）。