Studies in HIV-1 Pathogenesis and Transmission

HIV-1 发病机制和传播研究

基本信息

批准号：
8732335
负责人：
Bharat Ramratnam
金额：
$ 16.15万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-10 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8732335
关键词：
Acetates Adult Award Basic Science Benchmarking Biopsy CD4 Positive T Lymphocytes Caring Cells Cervical Chemical Agents Clinic Clinical Medicine Clinical Research Clinical Research Protocols Collection Cream Data Dependency Disease Dose Dyspareunia Enrollment Environment Epithelial Epithelium Equilibrium Estrogens Exposure to Female Fertility Foundations Funding Gene Expression Generations Genital system Goals Grant HIV HIV-1 Hormonal Hormones Hospitals Human Image Individual Infection Inflammatory Injury Instruction Integration Host Factors International AIDS Laboratories Life Cycle Stages Longevity Longitudinal Studies Low Dose Oral Contraceptives Macaca Measures Mediating Menstrual cycle Mentors Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mucous Membrane Nonoxynol 9 Oral Contraceptives Organ Culture Techniques Pathogenesis Pattern Peer Review Phase Play Postmenopause Predisposition Premenopause Principal Investigator Process Productivity Progesterone Proteins Proteomics Publications Recruitment Activity Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Training Risk Role SIV Safety Sampling Series Simplexvirus Site Survivors Symptoms Techniques Testing Tight Junctions Time Tissues Training United States National Institutes of Health Universities Vagina Vaginal Douching Vaginal Itching Viral Virus Woman abstracting alcohol research antimicrobial base career career development cervicovaginal cohort cytokine design genome wide association study hormonal contraception in vivo irritation macrophage patient oriented research pressure programs protein expression public health relevance reproductive reproductive hormone research study response sex sexual assault sexual trauma sexual violence simian human immunodeficiency virus translational study transmission process

项目摘要

DESCRIPTION (provided by applicant): The major goal of this Mid-Career Investigator Award in HIV related Patient-Oriented Research is to use the resulting protected time and effort to mentor a new generation of junior investigators at Brown University and its affiliated hospitals in translational studies of HIV pathogenesis and transmission. Mentees will be recruited from a robust educational infrastructure that includes several NIH funded HIV-centric programs including training grants (T32DA013911, T32MH078788, T32AA007459), international AIDS training and research programs (D43TW000237, D43TW009597) and Center grants including the Lifespan/Tufts/Brown CFAR (P30AI042853) and the Brown University Alcohol Research Center on HIV (P01AA019072). A recently funded 5-year research grant (R01HD072693) will be used as an immediately available foundation for mentoring and will allow instruction in patient oriented research that connects the clinic and laboratory with the pursuit of the following specifi aims (Aim 1) To quantify the effect of exogenous and endogenous reproductive hormones on HIV susceptibility of the reproductive tract of pre- and post-menopausal women. (Aim 2) To determine if reproductive hormones alter mechanisms responsible for HIV transmission through cervicovaginal epithelia. (Aim 3) To quantify the effect of reproductive hormones on HIV dependency factors in the female genital tract. The K24 mechanism will be used to support a new aim involving the longitudinal study of the cervicovaginal tract of adult women victims of sexual violence with the goal of characterizing inflammatory changes that result from sexual trauma. Pursuit of these aims will allow mentees to receive broad instruction on the design and management of clinical research protocols, collection and processing of biologic samples and execution of laboratory experiments involving state-of-the-art techniques in gene and protein expression and tissue imaging. Benchmarks for evaluating the progress of this K24 application will include the productivity of mentees measured by the number of abstracts, presentations and peer-reviewed publications as well as the number of career developments grants (NIH K- series, private foundation) that result from my patient oriented research program.

描述（由申请人提供）：该艾滋病毒相关的以患者为导向的研究中的职业生涯中期研究员奖的主要目标是利用由此产生的受保护的时间和精力来指导布朗大学及其附属医院的新一代初级研究人员 HIV发病机制和传播的转化研究。学员将从强大的教育基础设施中招募，其中包括多个 NIH 资助的以艾滋病毒为中心的项目，包括培训补助金（T32DA013911、T32MH078788、T32AA007459）、国际艾滋病培训和研究项目（D43TW000237、D43TW009597）以及包括 Lifespan/Tufts/Brown 在内的中心补助金恒虚警率（P30AI042853）和布朗大学艾滋病毒酒精研究中心（P01AA019072）。最近资助的一项为期 5 年的研究补助金 (R01HD072693) 将用作立即可用的指导基础，并将允许指导以患者为导向的研究，将诊所和实验室联系起来，以实现以下具体目标（目标 1）：量化外源性和内源性生殖激素对绝经前和绝经后妇女生殖道艾滋病毒易感性的影响。（目标 2）确定生殖激素是否会改变通过宫颈阴道上皮传播 HIV 的机制。（目标 3）量化生殖激素对女性生殖道 HIV 依赖因素的影响。 K24机制将用于支持一项新目标，该目标涉及对性暴力成年女性受害者的子宫颈阴道进行纵向研究，目的是表征性创伤引起的炎症变化。追求这些目标将使学员能够接受有关临床研究方案的设计和管理、生物样本的收集和处理以及涉及基因和蛋白质表达以及组织成像方面最先进技术的实验室实验的执行的广泛指导。评估此 K24 申请进度的基准将包括受训者的生产力（通过摘要、演示文稿和同行评审出版物的数量来衡量）以及职业发展补助金（NIH K 系列、私人基金会）的数量，这些补助金是由我的以患者为导向的研究计划。