Retrovirology Services

逆转录病毒学服务

• 批准号: 7676175
• 负责人: Bharat Ramratnam
• 金额: $ 18.62万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676175
• 关键词: AIDS clinical trial group; Animals; Antiretroviral resistance; Archives; Area; Award; Basic Science; Biological Assay; Categories; Clinical; Clinical Trials; Development; Evolution; Faculty; Fee-for-Service Plans; Funding; Genital system; Grant; HIV-1; Individual; Infection; Institution; International AIDS; Investigation; Laboratories; Longevity; Longitudinal Studies; Natural History; Operative Surgical Procedures; Population; Process; RNA Interference; Range; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Retrovirology; Sampling; Services; Site; Specimen; Students; Training Programs; Training and Education; United States National Institutes of Health; Universities; Work; base; design; falls; foot; infection related cancer; interest; microbicide; novel therapeutics; research study; tool; virology

Core H: Retrovirology Services The specific aims of the Retrovirology Services Core (Core H) of the Lifespan/Tufts/Brown CFAR are to (1) Provide basic virology laboratory services to CFAR investigators in support of their HIV-1 centered basic science investigation with emphasis on junior investigators and those individuals who have received CFAR developmental grant awards, (2) Process and archive clinical specimens from ongoing single and multi-site trials (AACTG, HPTN, HVTN, SUN), and (3) Facilitate the HIV-1 basic science training/education of pre- and postdoctoral students at CFAR institutions and those individuals participating in the Brown/Tufts University Fogarty AIDS International Research Training Program (D43TW000237). The Core began operations in September of 2002 and over the past 4 years has created and maintained 3500 square feet of new laboratory space with strong institutional support. This infrastructure has been used in part by seven recently recruited junior investigators working on various aspects of HIV-1 virology. All seven individuals have received new federal and/or private funding for their various projects. Presently, the research interests of Core users fall into the following broad categories: Microbicide design and delivery, Evolution of antiretroviral resistance in resource-poor areas, Development of novel therapeutic approaches to HIV-1 and related malignancies and infections, Characterization of HIV-1 genital burden, Designing optimum HIV-1 treatment paradigms in hard-to-reach populations or those residing in resource poor areas and, Longitudinal studies of the natural history of HIV-1 infection. In the current granting period, the Core will maintain all current assay and archiving capabilities and expand the range of services to provide tools for RNAi based assays. In addition, the Core will assist investigators in performing experiments with small animals in support of NIH funded investigations of microbicide design and delivery. The Core will continue to manage the 50,000+ archive of clinical samples and support the pursuit of new clinical trials by CFAR faculty. The Core will continue to offer assay support to recently funded investigators on a fee-for-service basis and continue to support meritorious projects by junior faculty who have not garnered independent grant support.

核心 H：逆转录病毒学服务 Lifespan/Tufts/Brown CFAR 逆转录病毒学服务核心（核心 H）的具体目标是 (1) 为 CFAR 研究人员提供基本病毒学实验室服务，以支持他们以 HIV-1 为中心的基本病毒学实验室服务 科学调查，重点关注初级研究者和接受过 CFAR 的个人 发展补助金，(2) 处理和存档来自正在进行的单点和多点的临床标本 试验（AACTG、HPTN、HVTN、SUN），以及 (3) 促进学前儿童和儿童的 HIV-1 基础科学培训/教育 CFAR 机构的博士后学生以及参与布朗/塔夫茨大学的个人 福格蒂艾滋病国际研究培训计划 (D43TW000237)。核心开始运营于 2002 年 9 月和过去 4 年里创建并维护了 3500 平方英尺的新 具有强大机构支持的实验室空间。最近，该基础设施已部分被七个使用 招募了从事 HIV-1 病毒学各个方面工作的初级研究人员。所有七个人都拥有 为他们的各种项目获得了新的联邦和/或私人资金。目前，研究兴趣为 核心用户分为以下几大类：杀菌剂设计和交付、抗逆转录病毒药物的演变 资源匮乏地区的耐药性，开发针对 HIV-1 及相关疾病的新治疗方法 恶性肿瘤和感染，HIV-1 生殖器负担的特征，设计最佳 HIV-1 治疗 难以接触到的人群或居住在资源匮乏地区的人群的范式，以及 HIV-1 感染的自然史。在当前的授权期内，核心将维持所有当前的检测 和归档能力并扩大服务范围，为基于 RNAi 的检测提供工具。在 此外，核心将协助研究人员用小动物进行实验，以支持 NIH 资助杀菌剂设计和交付的研究。核心将继续管理 50,000 多个 临床样本存档并支持 CFAR 教师开展新的临床试验。核心将 继续以按服务收费的方式向最近资助的研究人员提供检测支持，并继续 支持尚未获得独立拨款支持的初级教师的优秀项目。