Retrovirology Services

逆转录病毒学服务

• 批准号: 7676175
• 负责人: Bharat Ramratnam
• 金额: $ 18.62万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676175
• 关键词: AIDS clinical trial group; Animals; Antiretroviral resistance; Archives; Area; Award; Basic Science; Biological Assay; Categories; Clinical; Clinical Trials; Development; Evolution; Faculty; Fee-for-Service Plans; Funding; Genital system; Grant; HIV-1; Individual; Infection; Institution; International AIDS; Investigation; Laboratories; Longevity; Longitudinal Studies; Natural History; Operative Surgical Procedures; Population; Process; RNA Interference; Range; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Retrovirology; Sampling; Services; Site; Specimen; Students; Training Programs; Training and Education; United States National Institutes of Health; Universities; Work; base; design; falls; foot; infection related cancer; interest; microbicide; novel therapeutics; research study; tool; virology

Core H: Retrovirology Services The specific aims of the Retrovirology Services Core (Core H) of the Lifespan/Tufts/Brown CFAR are to (1) Provide basic virology laboratory services to CFAR investigators in support of their HIV-1 centered basic science investigation with emphasis on junior investigators and those individuals who have received CFAR developmental grant awards, (2) Process and archive clinical specimens from ongoing single and multi-site trials (AACTG, HPTN, HVTN, SUN), and (3) Facilitate the HIV-1 basic science training/education of pre- and postdoctoral students at CFAR institutions and those individuals participating in the Brown/Tufts University Fogarty AIDS International Research Training Program (D43TW000237). The Core began operations in September of 2002 and over the past 4 years has created and maintained 3500 square feet of new laboratory space with strong institutional support. This infrastructure has been used in part by seven recently recruited junior investigators working on various aspects of HIV-1 virology. All seven individuals have received new federal and/or private funding for their various projects. Presently, the research interests of Core users fall into the following broad categories: Microbicide design and delivery, Evolution of antiretroviral resistance in resource-poor areas, Development of novel therapeutic approaches to HIV-1 and related malignancies and infections, Characterization of HIV-1 genital burden, Designing optimum HIV-1 treatment paradigms in hard-to-reach populations or those residing in resource poor areas and, Longitudinal studies of the natural history of HIV-1 infection. In the current granting period, the Core will maintain all current assay and archiving capabilities and expand the range of services to provide tools for RNAi based assays. In addition, the Core will assist investigators in performing experiments with small animals in support of NIH funded investigations of microbicide design and delivery. The Core will continue to manage the 50,000+ archive of clinical samples and support the pursuit of new clinical trials by CFAR faculty. The Core will continue to offer assay support to recently funded investigators on a fee-for-service basis and continue to support meritorious projects by junior faculty who have not garnered independent grant support.

核心H：逆转录病毒学服务 寿命/簇/棕色CFAR的逆转录病毒学服务核心（核心H）的具体目的是（1） 为CFAR研究人员提供基本的病毒学实验室服务，以支持其HIV-1中心的基本 科学调查，重点是初级调查人员和那些接受CFAR的人 发展赠款奖，（2）来自正在进行的单一和多站点的过程和档案临床标本 试验（AACTG，HPTN，HVTN，太阳）和（3）促进HIV-1基础科学培训/教育 CFAR机构和那些参加布朗/塔夫茨大学的人的博士后学生 Fogarty AIDS国际研究培训计划（D43TW000237）。核心开始运营 2002年9月以及过去的4年中创建并维护了3500平方英尺的新型 实验室空间，具有强大的机构支持。该基础设施最近已被七个 从事HIV-1病毒学各个方面的招聘初级研究人员。这七个人都有 为其各种项目获得了新的联邦和/或私人资金。目前，研究兴趣 核心用户属于以下广泛类别：微生物剂设计和交付，抗逆转录病毒的演变 资源贫乏地区的抵抗力，开发新型HIV-1及相关治疗方法 恶性和感染，HIV-1生殖器负担的表征，设计最佳HIV-1治疗 难以到达的人群或居住在资源贫困地区的范例，以及纵向研究 HIV-1感染的自然史。在当前的授予期内，核心将维护所有当前测定 并归档功能并扩展服务范围，以提供基于RNAi的测定的工具。在 此外，核心将协助研究人员对小动物进行支持以支持NIH 资助了微生物设计和交付的研究。核心将继续管理50,000多个 临床样本的档案库，并支持CFAR教职员工追求新的临床试验。核心意愿 继续向最近资助的调查人员提供测定支持，以支付费用，并继续 支持尚未获得独立赠款支持的初级教师的职业项目。