West Virginia Stroke CoBRE

西弗吉尼亚州中风 CoBRE

• 批准号: 9313278
• 负责人: JAMES W. SIMPKINS
• 金额: $ 213.41万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313278
• 关键词: Acute; Address; Advisory Committees; Affect; Appalachian Region; Area; Biometry; Biostatistics Core; Cardiovascular system; Communities; Development; Facility Construction; Faculty; Funding; Human Resources; Link; Mentors; Neurosciences; Population; Prevention; Procedures; Process; Program Evaluation; Rehabilitation therapy; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk Factors; Stroke; Universities; West Virginia; bench to bedside; design; faculty mentor; formative assessment; programs; public health relevance; stroke rehabilitation

DESCRIPTION (provided by applicant): Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burden of stroke. Our approach is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence in basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatistics Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.

描述（由申请人提供）：提议的是西弗吉尼亚州中风 CoBRE（以下称为中风 CoBRE），重点关注中风领域。中风 CoBRE 是作为基础和转化中风研究中心 (CBTSR) 的重要组成部分而发起的，该中心是一个新成立的中心，致力于加强西弗吉尼亚大学 (WVU) 校园的基础和转化中风研究，以减轻中风患者的负担。中风。我们的方法是解决风险因素（特别是在阿巴拉契亚人群中普遍存在）影响中风的机制，从而破译这些风险因素的机制以及针对这些机制的潜在治疗方法。我们预计 CBTSR 将成为基础和转化性卒中研究的国家卓越中心，解决从实验室到临床到社区的卒中问题。这将通过培养初级研究者的研究独立性以及开发支持西弗吉尼亚大学卒中研究社区的核心资源来实现，从而增强西弗吉尼亚大学致力于卒中研究的资源和人员，以实现规划性研究活动。提出了三个核心和五个研究项目。行政核心将管理中风 CoBRE 的各个方面，包括密集的初级教师指导计划、咨询委员会和计划评估。实验性中风核心将为初级研究人员以及西弗吉尼亚大学神经科学和心血管研究界提供资源、专业知识和实验性中风程序。生物统计核心将在初级研究者发起的项目的设计和实施过程中提供关键的生物统计支持。拟议的研究项目由 5 名初级研究员组成，他们致力于通过 CoBRE 机制开发独立的研究项目。总的来说，他们的研究项目涉及中风预测、病因、预防、急性治疗和康复等相关领域。整个项目有一个完善和强化的指导项目以及严格的总结性和形成性评估项目。还提议以教师聘用、设施建设和捐款等形式提供机构支持。