Administrative Core

行政核心

• 批准号: 10708920
• 负责人: James R. Heath
• 金额: $ 37.85万
• 依托单位: INSTITUTE FOR SYSTEMS BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708920
• 关键词: Acceleration; Accountability; Advocate; Awareness; Biological; Cancer Biology; Clinic; Clinical; Clinical Oncology; Combination immunotherapy; Combined Modality Therapy; Communication; Communities; Cutaneous Melanoma; Data; Education and Outreach; Educational Materials; Educational process of instructing; Engineering; Environment; Evaluation; Faculty; Feedback; Funding; Goals; Immunotherapy; Infrastructure; Institution; Intellectual Property; Learning; Logistics; Malignant Neoplasms; Mentors; Monitor; Patients; Persons; Pilot Projects; Process; Program Description; Protocols documentation; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; STEM field; Schedule; Scientist; Self-Examination; Series; Solid Neoplasm; Specimen; Structure; Students; Systems Biology; Talents; Thinking; Tissues; Training Support; Translations; Underrepresented Minority; Underrepresented Populations; biobank; collaborative environment; design; flexibility; inhibitor; meetings; mouse model; multiple omics; outreach program; programs; spatiotemporal; targeted treatment; teacher; tool; translational goal; translational potential; tumor

Administration and Coordination Core Project Summary The administrative and coordination core of the proposed U54 Center for Spatiotemporal Tumor Analytics for Guiding Sequential Targeted Inhibitor : Immunotherapy Combinations (ST-Analytics is designed to promote and support the integrated research efforts of scientists from the ISB, Yale, and UCLA, as well as our Outreach program, our Pilot Projects and Cross-Consortium Projects. The scientific programs of ST-Analytics are designed to resolve how to best harness immunotherapy/targeted therapy sequential combinations for the treatment of solid tumors in the clinic, starting with a focus on metastatic cutaneous melanoma. This requires bringing together a cross-disciplinary mix of clinical, biological, physical, engineering, and computational scientists, as well as state-of-the-art, multiomic profiling tools, syngeneic mouse models, and a rich bio-repository of highly relevant patient tissues. Meeting the ST-Analytics scientific goals requires a responsive administrative structure that (i) promotes and enables effective communication and resource sharing between the ST-Analytics researchers and the broader Cancer Systems Biology Consortium (CSBC), (ii) establishes a highly interactive environment wherein ST-Analytics researchers can be good students and teachers of each other, (iii) promotes achieving the program specific aims in a timely manner, (iv) intervenes as early as possible when scientific and logistic conflicts arise, (v) promotes diversity in our scientific workforce through various mechanisms, including but not limited to seed project funding, outreach programs, and raising awareness of these critical issues during our remote and in-person meetings, and (vi) monitoring the scientific integrity and robustness of scientific designs. The ST-Analytics administrative CORE should facilitate the free flow of data, new ideas, experimental protocols, customized reagents, and biospecimens between the institutions. It should establish working relationships with other funded centers. It should facilitate clinical or commercial translation and educational outreach. It should encourage flexible thinking in anticipation of new opportunities or unexpected roadblocks. Finally, it should facilitate a healthy environment of self-evaluation.

行政及协调核心 项目概要 拟议的 U54 时空肿瘤分析中心的行政和协调核心 指导序贯靶向抑制剂：免疫治疗组合（ST-Analytics 旨在 促进和支持来自 ISB、耶鲁大学和加州大学洛杉矶分校以及我们的科学家的综合研究工作 外展计划、我们的试点项目和跨联盟项目。 ST-Analytics 的科学计划 旨在解决如何最好地利用免疫疗法/靶向疗法顺序组合来治疗 实体瘤的临床治疗，首先关注转移性皮肤黑色素瘤。这需要 汇集临床、生物学、物理、工程和计算的跨学科组合 科学家，以及最先进的多组学分析工具、同基因小鼠模型和丰富的生物存储库 高度相关的患者组织。实现 ST-Analytics 的科学目标需要积极响应的行政管理人员 (i) 促进并实现 ST-Analytics 之间的有效沟通和资源共享的结构 研究人员和更广泛的癌症系统生物学联盟 (CSBC)，(ii) 建立了高度互动的 ST-Analytics 研究人员可以成为彼此的好学生和好老师的环境，(iii) 促进 及时实现计划的具体目标，(iv) 在科学和可行的情况下尽早进行干预 出现后勤冲突，(v) 通过各种机制促进我们科学队伍的多样性，包括 但不限于种子项目资助、推广计划以及提高对这些关键问题的认识 我们的远程和面对面会议，以及（vi）监控科学的完整性和稳健性 设计。 ST-Analytics 管理核心应促进数据、新想法、实验的自由流动 机构之间的协议、定制试剂和生物样本。应建立工作 与其他资助中心的关系。它应该促进临床或商业翻译和教育 外展。它应该鼓励灵活的思维来预测新的机会或意外的障碍。 最后，它应该促进健康的自我评价环境。